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Q9K0C8 (RNC_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:NMB0686
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180416

Regions

Domain11 – 133123RNase III
Domain160 – 23071DRBM

Sites

Active site501 Potential
Active site1221 By similarity
Metal binding461Magnesium By similarity
Metal binding1191Magnesium By similarity
Metal binding1221Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9K0C8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 54D0F0473049607C

FASTA23926,853
        10         20         30         40         50         60 
MKDDVLKQQA HAAIQKKLGY AFRDISLLRQ ALTHRSHHAK HNERFEFVGD SILNYTVARM 

        70         80         90        100        110        120 
LFDAFPKLTE GELSRLRASL VNEGVLAEMA AEMNVGDGLY LGAGELKSGG FRRPSILADA 

       130        140        150        160        170        180 
MEAMFAAVSF DADFNTAEKV VRHLFADRVR RADFQNQAKD GKTALQEALQ ARRFALPKYR 

       190        200        210        220        230 
IEEQIGYAND SMFVISCDLG ELGFVCRAKG TSRKAAEQEA AKEALKWLEE KLPLKRKKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002098 Genomic DNA. Translation: AAF41104.1.
PIRE81169.
RefSeqNP_273728.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9K0C8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122586.NMB0686.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF41104; AAF41104; NMB0686.
GeneID902798.
KEGGnme:NMB0686.
PATRIC20356685. VBINeiMen85645_0860.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246809.
KOK03685.
OMALTHKSCK.
OrthoDBEOG6T1WVS.
ProtClustDBPRK00102.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-714-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_NEIMB
AccessionPrimary (citable) accession number: Q9K0C8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families