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Q9K086 (Q9K086_NEIMB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase HAMAP MF_00834
EC=2.6.1.62 HAMAP MF_00834
Alternative name(s):
7,8-diamino-pelargonic acid aminotransferase HAMAP MF_00834
7,8-diaminononanoate synthase HAMAP MF_00834
Diaminopelargonic acid synthase HAMAP MF_00834
Gene names
Name:bioA HAMAP MF_00834 EMBL AAF41145.1
Ordered Locus Names:NMB0732
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor By similarity. HAMAP MF_00834

Catalytic activity

S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate. HAMAP MF_00834

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00834

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. HAMAP MF_00834

Subunit structure

Homodimer By similarity. HAMAP MF_00834

Subcellular location

Cytoplasm By similarity HAMAP MF_00834.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. HAMAP MF_00834

Sequences

Sequence LengthMass (Da)Tools
Q9K086 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 366EBDFD1DEB97AD

FASTA43347,953
        10         20         30         40         50         60 
MPSEHQHISS LLDFDRTHLL HPYTSMTDPL PVYPVKRAEG VFIELADGTR LIDGMSSWWC 

        70         80         90        100        110        120 
AIHGYNHPVL NQAVETQMKQ MAHVMFGGLT HEPAVELGKL LVGILPQGLN RIFYADSGSI 

       130        140        150        160        170        180 
SVEVALKMAV QYQQARGLTA KQNIATVRRG YHGDTWNAMS VCDPETGMHH IFGSALPQRY 

       190        200        210        220        230        240 
FVDNPKSRFD DEWDGADLQP VRALFEVHHA DIAAFILEPV VQGAGGMYFY HPQYLRGLHD 

       250        260        270        280        290        300 
LCDEFDIMLI FDEIATGFGR TGKMFACEHA EVVPDIMCIG KGLSGGYMTL AAAITSQKVT 

       310        320        330        340        350        360 
ETISRGEAGV FMHGPTFMAN PLACAVACAS VKLLLSQDWQ ANIRRIESIL KGRLKAAWDI 

       370        380        390        400        410        420 
RGVKDVRVLG AIGVIELEKG VDMARFQADC VAQGIWVRPF GRLVYLMPPY IISDGVLTKL 

       430 
ADKTVQILKE HSK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF41145.1.
PIRD81164.
RefSeqNP_273774.1. NC_003112.2.

3D structure databases

HSSPHSSP built from PDB template 1QJ3 based on UniProtKB P12995.
ProteinModelPortalQ9K086.
SMRQ9K086. Positions 10-432.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000009772; EBNEIP00000009392; EBNEIG00000009772.
GeneID902845.
GenomeReviewsGene locus NMB0732 in contig AE002098_GR.
KEGGnme:NMB0732.
NMPDRfig|122586.1.peg.708.
PATRIC20356823. VBINeiMen85645_0932.
TIGRNMB0732.

Phylogenomic databases

GeneTreeEBGT00050000020132.
HOGENOMHBG725944.
OMAQAVETQM.
ProtClustDBCLSK877710.

Family and domain databases

HAMAPMF_00834. BioA.
[Tree]
InterProIPR005814. Aminotrans_3.
IPR005815. BioA.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK00833.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PTHR11986:SF8. BioA. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00508. BioA. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9K086_NEIMB
AccessionPrimary (citable) accession number: Q9K086
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info