Q9K083 (UBIA_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxybenzoate octaprenyltransferase
EC=2.5.1.-

Alternative name(s):
4-HB polyprenyltransferase

Gene names

Name:	ubiA
Ordered Locus Names:	NMB0735

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP MF_01635
Catalytic activity	4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP MF_01635
Cofactor	Magnesium By similarity. HAMAP MF_01635
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01635
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01635.
Sequence similarities	Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	prenyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	4-hydroxybenzoate octaprenyltransferase HAMAP MF_01635		PRO_0000262810
Regions
	Transmembrane	28 – 48	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Transmembrane	274 – 294	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9K083 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A9B961CB2A0FC2FA	FASTA	296	33,150
	10 20 30 40 50 60 MNPKSPLFLR LSDRLDVYLR LMRADKPIGT LLLLWPTYWA LWLASDGIPD LAVLAAFTIG 70 80 90 100 110 120 TFLMRSAGCV INDFADRDFD GAVERTKNRP FAQGRVKKKE ALLLTAFLCL LAALCLIPLN 130 140 150 160 170 180 HLTWLMSLPA LFLALTYPFT KRFFPIPQLY LGLAFSFGIP MAFAAVAGNV PPQAWILFAA 190 200 210 220 230 240 NVLWTLAYDT VYAMADKEDD LKIGIKTSAV TFGRYDIAAV MLCHGGFTLL MAVLGAVIGA 250 260 270 280 290 AWAYWTAIPI VLLLQYRQYA AIKSRVRQIC FETFLANNRI GWVWFTAIFA HTFFAK

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41148.1.
PIR	G81164.
RefSeq	NP_273777.1. NC_003112.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000009648; EBNEIP00000009268; EBNEIG00000009648.
GeneID	902848.
GenomeReviews	Gene locus NMB0735 in contig AE002098_GR.
KEGG	nme:NMB0735.
NMPDR	fig|122586.1.peg.711.
PATRIC	20356829. VBINeiMen85645_0935.
TIGR	NMB0735.
Phylogenomic databases
GeneTree	EBGT00050000021335.
HOGENOM	HBG324383.
OMA	VLIPWAA.
ProtClustDB	PRK12848.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0735-MONOMER.
Family and domain databases
HAMAP	MF_01635. UbiA. [Tree]
InterPro	IPR006370. HB_polyprenyl-transferase. IPR000537. UbiA_prenyltransferase. [Graphical view]
KO	K03179.
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01474. UbiA_proteo. 1 hit.
PROSITE	PS00943. UBIA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIA_NEIMB

Accession

Primary (citable) accession number: Q9K083

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program