Q9K041 (DCUP_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	NMB0781

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm Probable HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187618
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	46	1	Substrate By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Binding site	208	1	Substrate By similarity
	Binding site	326	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K041 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 83502DF9125E4E12	FASTA	354	39,105
	10 20 30 40 50 60 MISLKNDTFL RALLKQPVEY TPIWMMRQAG RYLPEYKATR AKAGSFLDLC KNTELATEVT 70 80 90 100 110 120 IQPLERFDLD AAILFSDILT VPDAMGLGLY FAEGEGPKFK RALQHEADIA KLHVPDMEKL 130 140 150 160 170 180 QYVFDAVTSI RKALDGRVPL IGFSGSPFTL ACYMVEGGGS KEFRTIKTMM YSRPDLLHKI 190 200 210 220 230 240 LDTNAQAVTA YLNAQIDAGA QAVQIFDTWG GVLSDAAFKE FSLKYIRQIV AGLKRESEGR 250 260 270 280 290 300 RVPVIVFAKG GGLWLESMAQ IGADALGLDW TCNIGEARRR VGKQVALQGN FDPFALFGTP 310 320 330 340 350 ESIRTEVARI LADYGHGSGH VFNLGHGINQ HADPEHAKIL VDTVHELSRQ YHGG

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41194.1.
PIR	B81158.
RefSeq	NP_273823.1. NC_003112.2.
3D structure databases
ProteinModelPortal	Q9K041.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000009144; EBNEIP00000008764; EBNEIG00000009144.
GeneID	902896.
GenomeReviews	Gene locus NMB0781 in contig AE002098_GR.
KEGG	nme:NMB0781.
NMPDR	fig|122586.1.peg.757.
PATRIC	20356941. VBINeiMen85645_0989.
TIGR	NMB0781.
Phylogenomic databases
GeneTree	EBGT00050000021377.
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0781-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_NEIMB

Accession

Primary (citable) accession number: Q9K041

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program