Q9JZR6 (PIP_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline iminopeptidase
Short name=PIP
EC=3.4.11.5

Alternative name(s):
Prolyl aminopeptidase
Short name=PAP

Gene names

Name:	pip
Ordered Locus Names:	NMB0927

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Proline iminopeptidase		PRO_0000080843
Sites
	Active site	107	1	Nucleophile By similarity
	Active site	260	1	By similarity
	Active site	287	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JZR6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9F883415B1C7B4A2	FASTA	310	34,957
	10 20 30 40 50 60 MYEIKQPFHS GYLQVSEIHQ IYWEESGNPD GVPVIFLHGG PGAGASPECR GFFNPDVFRI 70 80 90 100 110 120 VIIDQRGCGR SRPYACAEDN TTWDLVADIE KVREMLGIGK WLVFGGSWGS TLSLAYAQTH 130 140 150 160 170 180 PERVKGLVLR GIFLCRPSET VWLNEAGGVS RIYPEQWQKF VAPIAENRRN RLIEAYHGLL 190 200 210 220 230 240 FHQDEEVCLS AAKAWADWES YLIRFEPEEV DEDAYASLAI ARLENHYFVN GGWLQGDRAI 250 260 270 280 290 300 LNNIGKIRHI PTIIVQGRYD LCTPMQSAWA LSKAFPEAEL RVVQAGHRAF DPPLVDALVQ 310 AVEDILPHLL

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41334.1.
PIR	B81141.
RefSeq	NP_273966.1. NC_003112.2.
3D structure databases
ProteinModelPortal	Q9JZR6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000010875; EBNEIP00000010495; EBNEIG00000010875.
GeneID	903048.
GenomeReviews	Gene locus NMB0927 in contig AE002098_GR.
KEGG	nme:NMB0927.
NMPDR	fig|122586.1.peg.900.
PATRIC	20357323. VBINeiMen85645_1176.
TIGR	NMB0927.
Phylogenomic databases
GeneTree	EBGT00050000020931.
HOGENOM	HBG677789.
OMA	AELDWYY.
ProtClustDB	CLSK877812.
Enzyme and pathway databases
BioCyc	NMEN122586:NMB_0927-MONOMER.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
KO	K01259.
PANTHER	PTHR10992:SF12. PTHR10992:SF12. 1 hit.
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00111. ABHYDROLASE. PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. Pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_NEIMB

Accession

Primary (citable) accession number: Q9JZR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program