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Q9JZR1

- Q9JZR1_NEIMB

UniProt

Q9JZR1 - Q9JZR1_NEIMB

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Protein

tRNA-specific adenosine deaminase

Gene
tadA, NMB0933
Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) By similarity.UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Zinc; via pros nitrogen; catalytic By similarityUniRule annotation
Active sitei143 – 1431Proton donor By similarityUniRule annotation
Metal bindingi171 – 1711Zinc; catalytic By similarityUniRule annotation
Metal bindingi174 – 1741Zinc; catalytic By similarityUniRule annotation

GO - Molecular functioni

  1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

tRNA processingUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
Gene namesi
Name:tadAUniRule annotation
Ordered Locus Names:NMB0933Imported
OrganismiNeisseria meningitidis serogroup B (strain MC58)Imported
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB0933.

Structurei

3D structure databases

ProteinModelPortaliQ9JZR1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 189100CMP/dCMP deaminase zinc-binding By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000085050.
OMAiIMCAGAM.
OrthoDBiEOG64FKGZ.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR007077. TfoX_C.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF04994. TfoX_C. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JZR1-1 [UniParc]FASTAAdd to Basket

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MLTTPPLAPK TVAALHRLGI RTLEELRQNG SVKAFLLLKA SGLTLTKSTL    50
WQLESLLDGT PPQEMSQAHK ARLLAELKNH PPVAAFPPQE EMEHFMCEAL 100
RQAEQSSADG EIPVGAVIVS DGKIIASAHN TCIADCNVSR HAEINALAQA 150
GREIQNYRLD GCDIYITLEP CAMCASALIQ ARIRRVIYGA AEPKTGAAGS 200
IVNLFADKRL NTHTAIRGGI LQEECRAVLS RFFQNKRKG 239
Length:239
Mass (Da):25,988
Last modified:October 1, 2000 - v1
Checksum:iAF3444A8C60438FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF41340.1.
PIRiH81141.
RefSeqiNP_273972.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF41340; AAF41340; NMB0933.
GeneIDi903054.
KEGGinme:NMB0933.
PATRICi20357335. VBINeiMen85645_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF41340.1 .
PIRi H81141.
RefSeqi NP_273972.1. NC_003112.2.

3D structure databases

ProteinModelPortali Q9JZR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122586.NMB0933.

Protocols and materials databases

DNASUi 903054.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF41340 ; AAF41340 ; NMB0933 .
GeneIDi 903054.
KEGGi nme:NMB0933.
PATRICi 20357335. VBINeiMen85645_1182.

Phylogenomic databases

HOGENOMi HOG000085050.
OMAi IMCAGAM.
OrthoDBi EOG64FKGZ.

Enzyme and pathway databases

BioCyci NMEN122586:GHGG-971-MONOMER.

Family and domain databases

HAMAPi MF_00972. tRNA_aden_deaminase.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR007077. TfoX_C.
IPR028883. tRNA_aden_deaminase.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
PF04994. TfoX_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58Imported.

Entry informationi

Entry nameiQ9JZR1_NEIMB
AccessioniPrimary (citable) accession number: Q9JZR1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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