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Q9JZR1

- Q9JZR1_NEIMB

UniProt

Q9JZR1 - Q9JZR1_NEIMB

Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

    Catalytic activityi

    Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi141 – 1411Zinc; via pros nitrogen; catalyticUniRule annotation
    Active sitei143 – 1431Proton donorUniRule annotation
    Metal bindingi171 – 1711Zinc; catalyticUniRule annotation
    Metal bindingi174 – 1741Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    tRNA processingUniRule annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciNMEN122586:GHGG-971-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
    Gene namesi
    Name:tadAUniRule annotation
    Ordered Locus Names:NMB0933Imported
    OrganismiNeisseria meningitidis serogroup B (strain MC58)Imported
    Taxonomic identifieri122586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000425: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi122586.NMB0933.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JZR1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 189100CMP/dCMP deaminase zinc-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
    Contains 1 CMP/dCMP deaminase zinc-binding domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000085050.
    OMAiIMCAGAM.
    OrthoDBiEOG64FKGZ.

    Family and domain databases

    HAMAPiMF_00972. tRNA_aden_deaminase.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR007077. TfoX_C.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF04994. TfoX_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JZR1-1 [UniParc]FASTAAdd to Basket

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    MLTTPPLAPK TVAALHRLGI RTLEELRQNG SVKAFLLLKA SGLTLTKSTL    50
    WQLESLLDGT PPQEMSQAHK ARLLAELKNH PPVAAFPPQE EMEHFMCEAL 100
    RQAEQSSADG EIPVGAVIVS DGKIIASAHN TCIADCNVSR HAEINALAQA 150
    GREIQNYRLD GCDIYITLEP CAMCASALIQ ARIRRVIYGA AEPKTGAAGS 200
    IVNLFADKRL NTHTAIRGGI LQEECRAVLS RFFQNKRKG 239
    Length:239
    Mass (Da):25,988
    Last modified:October 1, 2000 - v1
    Checksum:iAF3444A8C60438FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF41340.1.
    PIRiH81141.
    RefSeqiNP_273972.1. NC_003112.2.

    Genome annotation databases

    EnsemblBacteriaiAAF41340; AAF41340; NMB0933.
    GeneIDi903054.
    KEGGinme:NMB0933.
    PATRICi20357335. VBINeiMen85645_1182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF41340.1 .
    PIRi H81141.
    RefSeqi NP_273972.1. NC_003112.2.

    3D structure databases

    ProteinModelPortali Q9JZR1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122586.NMB0933.

    Protocols and materials databases

    DNASUi 903054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF41340 ; AAF41340 ; NMB0933 .
    GeneIDi 903054.
    KEGGi nme:NMB0933.
    PATRICi 20357335. VBINeiMen85645_1182.

    Phylogenomic databases

    HOGENOMi HOG000085050.
    OMAi IMCAGAM.
    OrthoDBi EOG64FKGZ.

    Enzyme and pathway databases

    BioCyci NMEN122586:GHGG-971-MONOMER.

    Family and domain databases

    HAMAPi MF_00972. tRNA_aden_deaminase.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR007077. TfoX_C.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF04994. TfoX_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC58Imported.

    Entry informationi

    Entry nameiQ9JZR1_NEIMB
    AccessioniPrimary (citable) accession number: Q9JZR1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3