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Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Zinc; catalyticUniRule annotation1
Metal bindingi141Zinc; via pros nitrogen; catalyticUniRule annotation1
Active sitei143Proton donorUniRule annotation1
Metal bindingi171Zinc; catalyticUniRule annotation1
Metal bindingi174Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

tRNA processingUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
Gene namesi
Name:tadAUniRule annotation
Ordered Locus Names:NMB0933Imported
OrganismiNeisseria meningitidis serogroup B (strain MC58)Imported
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiQ9JZR1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB0933.

Structurei

3D structure databases

ProteinModelPortaliQ9JZR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 223CMP/dCMP-type deaminaseInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
Contains 1 CMP/dCMP-type deaminase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z6B. Bacteria.
COG0590. LUCA.
COG3070. LUCA.
HOGENOMiHOG000085050.
OMAiRIGRIFF.
OrthoDBiPOG091H01W1.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR007077. TfoX_C.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF14437. MafB19-deam. 1 hit.
PF04994. TfoX_C. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTPPLAPK TVAALHRLGI RTLEELRQNG SVKAFLLLKA SGLTLTKSTL
60 70 80 90 100
WQLESLLDGT PPQEMSQAHK ARLLAELKNH PPVAAFPPQE EMEHFMCEAL
110 120 130 140 150
RQAEQSSADG EIPVGAVIVS DGKIIASAHN TCIADCNVSR HAEINALAQA
160 170 180 190 200
GREIQNYRLD GCDIYITLEP CAMCASALIQ ARIRRVIYGA AEPKTGAAGS
210 220 230
IVNLFADKRL NTHTAIRGGI LQEECRAVLS RFFQNKRKG
Length:239
Mass (Da):25,988
Last modified:October 1, 2000 - v1
Checksum:iAF3444A8C60438FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF41340.1.
PIRiH81141.
RefSeqiNP_273972.1. NC_003112.2.
WP_002225332.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF41340; AAF41340; NMB0933.
GeneIDi903054.
KEGGinme:NMB0933.
PATRICi20357335. VBINeiMen85645_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF41340.1.
PIRiH81141.
RefSeqiNP_273972.1. NC_003112.2.
WP_002225332.1. NC_003112.2.

3D structure databases

ProteinModelPortaliQ9JZR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB0933.

Proteomic databases

PaxDbiQ9JZR1.

Protocols and materials databases

DNASUi903054.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF41340; AAF41340; NMB0933.
GeneIDi903054.
KEGGinme:NMB0933.
PATRICi20357335. VBINeiMen85645_1182.

Phylogenomic databases

eggNOGiENOG4108Z6B. Bacteria.
COG0590. LUCA.
COG3070. LUCA.
HOGENOMiHOG000085050.
OMAiRIGRIFF.
OrthoDBiPOG091H01W1.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR007077. TfoX_C.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF14437. MafB19-deam. 1 hit.
PF04994. TfoX_C. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9JZR1_NEIMB
AccessioniPrimary (citable) accession number: Q9JZR1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.