Q9JZQ3 (METF_NEIMB) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 74.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 5,10-methylenetetrahydrofolate reductase EC=1.5.1.20 | ||||
| Gene names |
| ||||
| Organism | Neisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 122586 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › ![]() |
Protein attributes
| Sequence length | 292 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Miscellaneous | Present in outer membrane vesicle formulations which are used as vaccines in human. |
| Sequence similarities | Belongs to the methylenetetrahydrofolate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Methionine biosynthesis |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate interconversionInferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | cytosol Inferred from electronic annotation. Source: InterPro |
| Molecular_function | methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 292 | 292 | 5,10-methylenetetrahydrofolate reductase | PRO_0000320271 | |||
Sequences
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References
| [1] | "Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. Venter J.C.Science 287:1809-1815(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58. |
| [2] | "Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254." Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X. Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Strain: NZ98/254 / Serogroup B. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE002098 Genomic DNA. Translation: AAF41349.1. |
| PIR | D81140. |
| RefSeq | NP_273981.1. NC_003112.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2FMO based on UniProtKB P0AEZ1. |
| ProteinModelPortal | Q9JZQ3. |
| SMR | Q9JZQ3. Positions 3-292. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 122586.NMB0943. |
Proteomic databases | |
| PRIDE | Q9JZQ3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAF41349; AAF41349; NMB0943. |
| GeneID | 903063. |
| KEGG | nme:NMB0943. |
| PATRIC | 20357367. VBINeiMen85645_1198. |
Phylogenomic databases | |
| eggNOG | COG0685. |
| HOGENOM | HOG000246232. |
| KO | K00297. |
| OMA | SITQMFF. |
| ProtClustDB | PRK09432. |
Enzyme and pathway databases | |
| BioCyc | NMEN122586:GHGG-943-MONOMER. |
| UniPathway | UPA00193. |
Family and domain databases | |
| InterPro | IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view] |
| Pfam | PF02219. MTHFR. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00676. fadh2. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | METF_NEIMB | ||||||||
| Accession | Primary (citable) accession number: Q9JZQ3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
