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Q9JZ55 (KDSA_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene names
Name:kdsA
Ordered Locus Names:NMB1283
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056

Subcellular location

Cytoplasm By similarity HAMAP MF_00056.

Sequence similarities

Belongs to the KdsA family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-8-phosphooctulonate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2802802-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056
PRO_0000187143

Secondary structure

1 ............................................. 280
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9JZ55 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7183B4CC6E3FEE28

FASTA28030,483
        10         20         30         40         50         60 
MDIKINDITL GNNSPFVLFG GINVLESLDS TLQTCAHYVE VTRKLGIPYI FKASFDKANR 

        70         80         90        100        110        120 
SSIHSYRGVG LEEGLKIFEK VKAEFGIPVI TDVHEPHQCQ PVAEVCDVIQ LPAFLARQTD 

       130        140        150        160        170        180 
LVVAMAKTGN VVNIKKPQFL SPSQMKNIVE KFHEAGNGKL ILCERGSSFG YDNLVVDMLG 

       190        200        210        220        230        240 
FGVMKQTCGN LPVIFDVTHS LQTRDAGSAA SGGRRAQALD LALAGMATRL AGLFLESHPD 

       250        260        270        280 
PKLAKCDGPS ALPLHLLEDF LIRIKALDDL IKSQPILTIE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF41659.1.
PIRB81100.
RefSeqNP_274303.1. NC_003112.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QKFX-ray1.75A/B/C/D1-280[»]
3FYOX-ray1.90A/B/C/D1-280[»]
3FYPX-ray1.85A/B/C/D1-280[»]
3QPYX-ray1.95A/B/C/D1-280[»]
3QPZX-ray1.75A/B/C/D1-280[»]
3QQ0X-ray1.90A/B/C/D1-280[»]
3QQ1X-ray2.70A/B/C/D1-280[»]
3STCX-ray1.91A/B/C/D1-280[»]
3STEX-ray2.05A/B/C/D1-280[»]
3STFX-ray1.90A/B/C/D1-280[»]
3STGX-ray2.20A/B/C/D1-280[»]
ProteinModelPortalQ9JZ55.
SMRQ9JZ55. Positions 1-277.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000008995; EBNEIP00000008615; EBNEIG00000008995.
GeneID903705.
GenomeReviewsGene locus NMB1283 in contig AE002098_GR.
KEGGnme:NMB1283.
NMPDRfig|122586.1.peg.1237.
PATRIC20358193. VBINeiMen85645_1608.
TIGRNMB1283.

Phylogenomic databases

GeneTreeEBGT00050000020773.
HOGENOMHBG575990.
OMAQLILCDR.
ProtClustDBPRK05198.

Enzyme and pathway databases

BioCycNMEN122586:NMB_1283-MONOMER.

Family and domain databases

HAMAPMF_00056. KDO8P_synth.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01627.
PANTHERPTHR21057:SF2. KDO8P_synthase. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01362. KDO8P_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSA_NEIMB
AccessionPrimary (citable) accession number: Q9JZ55
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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