Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9JYX5 (Q9JYX5_NEIMB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:NMB1384
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria ›

Protein attributes

Sequence length916 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1301O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q9JYX5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D5DFE651B804782F

FASTA916101,371
        10         20         30         40         50         60 
MTDATIRHDH KFALETLPVS LEDEMRKSYL DYAMSVIVGR ALPDVRDGLK PVHRRVLYAM 

        70         80         90        100        110        120 
HELKNNWNAA YKKSARIVGD VIGKYHPHGD TAVYDTIVRM AQNFAMRYVL IDGQGNFGSV 

       130        140        150        160        170        180 
DGLAAAAMRY TEIRMAKISH EMLADIEEET VNFGPNYDGS EHEPLVLPTR FPTLLVNGSS 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLSDTVN ACLRLLDAPD TEIDELIDII QAPDFPTGAT IYGLSGVREG 

       250        260        270        280        290        300 
YKTGRGRVVM RGKTHIEPIG RNGEREAIVI DEIPYQVNKA KLVEKIGDLV REKTLEGISE 

       310        320        330        340        350        360 
LRDESDKSGM RVVIELKRNE NAEVVLNQLY KLTPLQDSFG INMVVLVDGQ PRLLNLKQIL 

       370        380        390        400        410        420 
SEFLRHRREV VTRRTLFRLK KARHEGHIAE GKAVALSNID EIIKLIKESP NAAEAKDKLL 

       430        440        450        460        470        480 
ARPWRSSLVE EMLTRSGLDL EMMRPEGLAA NIGLKEQGYY LSEIQADAIL RMSLRNLTGL 

       490        500        510        520        530        540 
DQEEIVESYK NLMGKIIDFV DILSKPERIT QIIRDELEEI KTNYGDERRS EINPFGGDIA 

       550        560        570        580        590        600 
DEDLIPQREM VVTLTHGGYI KTQPTTDYQA QRRGGRGKQA AATKDEDFIE TLFVANTHDY 

       610        620        630        640        650        660 
LMCFTNLGKC HWIKVYKLPE GGRNSRGRPI NNVIQLEEGE KVSAILAVRE FPEDQYVFFA 

       670        680        690        700        710        720 
TAQGMVKKVQ LSAFKNVRAQ GIKAIALKEG DYLVGAAQTG GADDIMLFSN LGKAIRFNEY 

       730        740        750        760        770        780 
WEKSGNDEAE DADIETEISD GIEDETADSE NALPSGKHGV RPSGRGSGGL RGMRLPADGK 

       790        800        810        820        830        840 
IVSLITFAPE TEESGLQVLT ATANGYGKRT PIADYSRKNK GGQGNIAINT GERNGDLVAA 

       850        860        870        880        890        900 
TLVGETDDLM LITSGGVLIR TKVEQIRETG RAAAGVKLIN LDEGETLVSL ERVAEDESEL 

       910 
SDASVISNVT EPEVEN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF41750.1.
PIRA81089.
RefSeqNP_274400.1. NC_003112.2.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortalQ9JYX5.
SMRQ9JYX5. Positions 38-533.
ModBaseSearch...

Protein-protein interaction databases

STRING122586.NMB1384.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF41750; AAF41750; NMB1384.
GeneID903806.
KEGGnme:NMB1384.
PATRIC20358447. VBINeiMen85645_1735.

Phylogenomic databases

HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-1381-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9JYX5_NEIMB
AccessionPrimary (citable) accession number: Q9JYX5
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info