Aminopeptidase N - Neisseria meningitidis serogroup B

Preferred order of sections

Names and origin

Protein names

Submitted name:
Aminopeptidase N EMBL AAF41777.1
EC=3.4.11.2 EMBL AAF41777.1

Gene names

Name:	pepN EMBL AAF41777.1
Ordered Locus Names:	NMB1416

Organism

Neisseria meningitidis serogroup B

Taxonomic identifier

491 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 2GTQ Zinc PDB 2GTQ
Molecular function	Aminopeptidase EMBL AAF41777.1 Hydrolase Protease
Technical term	3D-structure PDB 2GTQ Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

293

1

Zinc; via tele nitrogen PDB 2GTQ

Metal binding

297

1

Zinc; via tele nitrogen PDB 2GTQ

Metal binding

316

1

Zinc PDB 2GTQ

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JYV4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 19D37D5A8F863C7D
Show »

FASTA

867

97,681

        10         20         30         40         50         60 
MSKTVHYLKD YQTPAYHILK TDLHFDINEP QTVVKSRLTV EPQRVGEPLV LDGSAKLLSV 

        70         80         90        100        110        120 
KINGAAADYV LEGETLTIAG VPSERFTVEV ETEILPAENK SLMGLYASGG NLFTQCEPEG 

       130        140        150        160        170        180 
FRKITFYIDR PDVMSKFTTT IVADKKRYPV LLSNGNKIDG GEFSDGRHWV KWEDPFSKPS 

       190        200        210        220        230        240 
YLFALVAGDL AVTEDYFTTM SGRNVKIEFY TTEADKPKVG FAVESLKNAM KWDETRFGLE 

       250        260        270        280        290        300 
YDLDIFMVVA VGDFNMGAME NKGLNIFNTK FVLADSRTAT DTDFEGIESV VGHEYFHNWT 

       310        320        330        340        350        360 
GNRVTCRDWF QLSLKEGLTV FRDQEFSGDR ASRAVRRIEN IRLLRQHQFP EDAGPTAHPV 

       370        380        390        400        410        420 
RPASYEEMNN FYTMTVYEKG AEVVRMYHTL LGEEGFQKGM KLYFQRHDGQ AVTCDDFRAA 

       430        440        450        460        470        480 
MADANGINLD QFALWYSQAG TPVLEAEGRL KNNIFELTVK QTVPPTPDMT DKQPMMIPVK 

       490        500        510        520        530        540 
VGLLNRNGEA VAFDYQGKRA TEAVLLLTEA EQTFLLEGVT EAVVPSLLRG FSAPVHLNYP 

       550        560        570        580        590        600 
YSDDDLLLLL AHDSDAFTRW EAAQTLYRRA VAANLATLSD GVELPKHEKL LAAVEKVISD 

       610        620        630        640        650        660 
DLLDNAFKAL LLGVPSEAEL WDGAENIDPL RYHQAREALL DTLAVHFLPK WHELNRQAAK 

       670        680        690        700        710        720 
QENQSYEYSP EAAGWRTLRN VCRAFVLRAD PAHIETVAEK YGEMAQNMTH EWGILSAVNG 

       730        740        750        760        770        780 
NESDTRNRLL AQFADKFSDD ALVMDKYFAL VGSSRRSDTL QQVRTALQHP KFSLENPNKA 

       790        800        810        820        830        840 
RSLIGSFSRN VPHFHAEDGS GYRFIADKVI EIDRFNPQVA ARLVQAFNLC NKLEPHRKNL 

       850        860 
VKQALQRIRA QEGLSKDVGE IVGKILD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. Venter J.C. Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B.
[2]	"Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis." Nocek B., Mulligan R., Bargassa M., Collart F., Joachimiak A. Proteins 70:273-279(2008) [PubMed: 17876832] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE002098 Genomic DNA. Translation: AAF41777.1.

PIR

F81086.

RefSeq

NP_274428.1. NC_003112.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GTQ	X-ray	2.05	A	1-867	[»]

ProteinModelPortal

Q9JYV4.

SMR

Q9JYV4. Positions 4-867.

ModBase

Search...

Protein family/group databases

MEROPS

M01.005.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBNEIT00000009407; EBNEIP00000009027; EBNEIG00000009407.

GeneID

903838.

GenomeReviews

Gene locus NMB1416 in contig AE002098_GR.

KEGG

nme:NMB1416.

NMPDR

fig|122586.1.peg.1362.

PATRIC

20358515. VBINeiMen85645_1769.

TIGR

NMB1416.

Phylogenomic databases

GeneTree

EBGT00050000021177.

HOGENOM

HBG289207.

OMA

DIFMIVA.

ProtClustDB

PRK14015.

Family and domain databases

InterPro

IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view]

Gene3D

G3DSA:1.25.50.10. G3DSA:1.25.50.10. 1 hit.

KO

K01256.

PANTHER

PTHR11533:SF8. Pept_M1_pepN. 1 hit.
PTHR11533. Peptidase_M1. 1 hit.

Pfam

PF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]

PRINTS

PR00756. ALADIPTASE.

TIGRFAMs

TIGR02414. PepN_proteo. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9JYV4_NEIMB

Accession

Primary (citable) accession number: Q9JYV4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)