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Q9JYQ9 (SYW_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:NMB1471
OrganismNeisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]
Taxonomic identifier122586 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136654

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140
Motif203 – 2075"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2061ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JYQ9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0AE32C8C00B621AA

FASTA33637,616
        10         20         30         40         50         60 
MSKKRVLTGV TTTGIPHLGN YVGAIRPAVR AAQNLDTESF LFLADYHGII KCHEPEMIHQ 

        70         80         90        100        110        120 
STQAVAATWL ACGLDPERTT FYRQSDTPEV MELNWILTCI TAKGLMNRAH AYKAAVQANA 

       130        140        150        160        170        180 
ENGQEDPDFG VEMGLFSYPI LMTADILMFN ANEVPVGRDQ IQHVEMARDI AGRFNHRFRE 

       190        200        210        220        230        240 
LFTLPEVKID ENVELLVGLD GRKMSKSYGN TIPLWENDKK TQKSVNKIIT NMKEPGEPKQ 

       250        260        270        280        290        300 
PDESPLFEIY KAFSTPSETV EFTKMLADGL AWGEAKKLLA AKINAELAEP RERYNELTAD 

       310        320        330 
PSQIEEILQA GAAKARKEAR ELLDKVRDAV GIRPLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002098 Genomic DNA. Translation: AAF41828.1.
PIRB81081.
RefSeqNP_274480.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9JYQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122586.NMB1471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF41828; AAF41828; NMB1471.
GeneID903893.
KEGGnme:NMB1471.
PATRIC20358707. VBINeiMen85645_1863.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMAYGYGHAK.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycNMEN122586:GHGG-1511-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_NEIMB
AccessionPrimary (citable) accession number: Q9JYQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries