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Q9JXX4 (CARA_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain
EC=6.3.5.5
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain
Gene names
Name:carA
Ordered Locus Names:NMB1849
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP MF_01209

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.

Sequence similarities

Belongs to the CarA family.

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Carbamoyl-phosphate synthase small chain HAMAP MF_01209
PRO_0000112299

Regions

Domain190 – 377188Glutamine amidotransferase type-1
Region1 – 186186CPSase HAMAP MF_01209

Sites

Active site2661Nucleophile By similarity
Active site3501 By similarity
Active site3521 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JXX4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 36733FC0806B1670

FASTA37740,587
        10         20         30         40         50         60 
MSTPALLVLA DGSVFHGTSI GYEGSTSGEV VFNTSMTGYQ EILTDPSYCK QIVTLTYPHI 

        70         80         90        100        110        120 
GNTGTNAEDE ESRSVYAAGL IIRDLPLLHS NFRASESLHD YLVRNKTVAI ADIDTRRLTT 

       130        140        150        160        170        180 
LLREKGAQGG AILTGADATI EKAQELIAAF GSMVGKDLAK EVSCTETYEW TEGEWALGKG 

       190        200        210        220        230        240 
FVTPDEQPYH VVAYDFGVKT NILRMLASRG CRLTVVPAQT SAEDVLALNP DGVFLSNGPG 

       250        260        270        280        290        300 
DPEPCTYAIK AVQKLIESGK PIFGICLGHQ LISLAIGAKT LKMRFSHHGA NHPVQDLDSG 

       310        320        330        340        350        360 
KVVITSQNHG FAVDADTLPA NARITHKSLF DNTLQGIELT DKPVFCFQGH PEASPGPQDV 

       370 
GYLFDKFIGN MKAAKRA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF42183.1.
PIRF81034.
RefSeqNP_274845.1. NC_003112.2.

3D structure databases

ProteinModelPortalQ9JXX4.
SMRQ9JXX4. Positions 5-368.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000010517; EBNEIP00000010137; EBNEIG00000010517.
GeneID903249.
GenomeReviewsGene locus NMB1849 in contig AE002098_GR.
KEGGnme:NMB1849.
NMPDRfig|122586.1.peg.1779.
PATRIC20359721. VBINeiMen85645_2366.
TIGRNMB1849.

Phylogenomic databases

GeneTreeEBGT00050000020378.
HOGENOMHBG286341.
OMAFTYPELG.
ProtClustDBPRK12564.

Enzyme and pathway databases

BioCycNMEN122586:NMB_1849-MONOMER.

Family and domain databases

HAMAPMF_01209. CPSase_S_chain.
[Tree]
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
Gene3DG3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit.
KOK01956.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCARA_NEIMB
AccessionPrimary (citable) accession number: Q9JXX4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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