ID   Q9JXH4_NEIMB            Unreviewed;       274 AA.
AC   Q9JXH4;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=DNA ligase {ECO:0000313|EMBL:AAF42368.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:AAF42368.1};
GN   Name=ligA-2 {ECO:0000313|EMBL:AAF42368.1};
GN   OrderedLocusNames=NMB2048 {ECO:0000313|EMBL:AAF42368.1};
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF42368.1, ECO:0000313|Proteomes:UP000000425};
RN   [1] {ECO:0000313|EMBL:AAF42368.1, ECO:0000313|Proteomes:UP000000425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58 {ECO:0000313|EMBL:AAF42368.1,
RC   ECO:0000313|Proteomes:UP000000425};
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA   White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA   Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE002098; AAF42368.1; -; Genomic_DNA.
DR   PIR; D81013; D81013.
DR   RefSeq; NP_275038.1; NC_003112.2.
DR   RefSeq; WP_002225694.1; NC_003112.2.
DR   AlphaFoldDB; Q9JXH4; -.
DR   STRING; 122586.NMB2048; -.
DR   PaxDb; 122586-NMB2048; -.
DR   DNASU; 904041; -.
DR   KEGG; nme:NMB2048; -.
DR   PATRIC; fig|122586.8.peg.2625; -.
DR   HOGENOM; CLU_021047_0_0_4; -.
DR   InParanoid; Q9JXH4; -.
DR   OrthoDB; 9767858at2; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07896; Adenylation_kDNA_ligase_like; 1.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:AAF42368.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..274
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004327670"
FT   DOMAIN          124..202
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   274 AA;  30713 MW;  43BA457AD6AA602D CRC64;
     MIKKTIGGII PIFTAVFIPA SAGAADLMLA QEYKGQDIAG WAMSEKLDGV RAYWDGKHLM
     SRQGYAFAPP KGFTAQFPPY PLDGELYSGR GQFEQISATV RSVSSDWRGI RLHVFDVPKA
     QGNLYQRLAV ATQWLKTHPN APITIIPQIK VRDRQHAMDF LKQIEAQGGE GVMLRQPESR
     YSGGRSSQLL KLKSQYDDEC TVTRHYEGKG RNAGRLGAVG CKNRHGEFRI GSGFKDKDRD
     NPPKIGTLIT YRYRGFTRKG TPKFATFVRV RTDR
//