Reviewed,
UniProtKB/Swiss-Prot Q9JXA3 (PUR2_NEIMB)
Last modified
November 3, 2009.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylamine--glycine ligase EC=6.3.4.13 Alternative name(s): GARS Glycinamide ribonucleotide synthetase Phosphoribosylglycinamide synthetase | ||||
| Gene names |
| ||||
| Organism | Neisseria meningitidis serogroup B [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 491 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria |
Protein attributes
| Sequence length | 423 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP MF_00138 |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP MF_00138 |
| Sequence similarities | Belongs to the GARS family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW phosphoribosylamine-glycine ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 423 | 423 | Phosphoribosylamine--glycine ligase HAMAP MF_00138 | PRO_0000151467 | |||||
Regions | |||||||||
| Domain | 107 – 314 | 208 | ATP-grasp | ||||||
| Nucleotide binding | 133 – 194 | 62 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 284 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 286 | 1 | Magnesium or manganese By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. Venter J.C.Science 287:1809-1815(2000) [PubMed: 10710307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58 / Serogroup B. |
Cross-references
Sequence databases | |
|---|---|
| AE002098 Genomic DNA. Translation: AAF42459.1. | |
| PIR | E81000. |
| RefSeq | NP_275136.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GSO based on UniProtKB P15640. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 903221. |
| GenomeReviews | Gene locus NMB2151 in contig AE002098_GR. |
| KEGG | nme:NMB2151. |
| NMPDR | fig|122586.1.peg.2070. |
| TIGR | NMB2151. |
Phylogenomic databases | |
| HOGENOM | Q9JXA3. |
| OMA | IEYNCRF. |
Enzyme and pathway databases | |
| BioCyc | NMEN122586:NMB_2151-MON. |
| BRENDA | 6.3.4.13. 293828. |
Family and domain databases | |
| HAMAP | MF_00138. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. IPR020561. PRibGlycinamid_synth_ATP-grasp. IPR000115. PRibGlycinamide_synth. IPR020560. PRibGlycinamide_synth_C-dom. IPR020559. PRibGlycinamide_synth_CS. IPR020562. PRibGlycinamide_synth_N-dom. [Graphical view] |
| Gene3D | G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.90.600.10. Gars. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF01071. GARS_A. 1 hit. PF02843. GARS_C. 1 hit. PF02844. GARS_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00877. purD. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00184. GARS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR2_NEIMB | ||||||||
| Accession | Primary (citable) accession number: Q9JXA3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


