Reviewed, UniProtKB/Swiss-Prot Q9JX80 (NUOC_NEIMA)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C
    NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	NMA0017

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01357
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits nuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP photosynthesis, light reaction Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	NADH-quinone oxidoreductase subunit C HAMAP MF_01357		PRO_0000118672

Sequences

	Sequence		Length	Mass (Da)
	Q9JX80-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4531D136456A8DEC	FASTA	197	22,978
	10 20 30 40 50 60 MASIQNLYET VVGVLGDQAS KVISALGEIT VECLPEHYIS VMTALRDHEE LHFELLVDLC 70 80 90 100 110 120 GVDYSTYKNE VWQGKRFAVV SQLLSVKNNQ RIRVRVWVSD DDFPVVESVV DIYNSADWYE 130 140 150 160 170 180 REAFDMYGIM FNNHPDLRRI LTDYGFVGHP FRKDFPISGY VEMRYDEEQK RVIYQPVTIE 190 PREITPRIVR EENYGGQ

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL157959 Genomic DNA. Translation: CAM07345.1.
PIR	E81992.
RefSeq	YP_002341579.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	906036.
GenomeReviews	Gene locus NMA0017 in contig AL157959_GR.
KEGG	nma:NMA0017.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9JX80.
OMA	Q9JX80. VFAPDDD.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA0017-MON.
BRENDA	1.6.99.5. 292829.
Family and domain databases
HAMAP	MF_01357. [Tree]
InterPro	IPR010218. NADH_DH_csu. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC_NEIMA

Accession

Primary (citable) accession number: Q9JX80
Secondary accession number(s): A1INN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)