Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JX45

- LPXB_NEIMA

UniProt

Q9JX45 - LPXB_NEIMA

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciNMEN122587:GI3Q-63-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:NMA0069
    OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
    Taxonomic identifieri122587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000626: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Lipid-A-disaccharide synthasePRO_0000190171Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi122587.NMA0069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JX45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiRRSEIRH.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JX45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKKSPLIA VSVGEASGDL LGAHLIRAIR KRCPQARFVG IGGELMKAEG    50
    FESLYDQERL AVRGFVEVVR RLPEILRIRR GLVRDLLSLK PDVFVGIDAP 100
    DFNLGVAERL KRSGIPTVHY VSPSVWAWRR ERVGKIVHQV NRVLCLFPME 150
    PQLYLDAGGR AEFVGHPMAQ LMPLEDDRET ARKTLGVDAG IPVFALLPGS 200
    RVSEIDYMAP VFFQTALLLL KRYPAARFLL PAATEATKRR LAEILQRSEF 250
    AGLPLTVTDR QSETVCRAAD AVLVTSGTAT LEVALCKRPM VISYKISPLT 300
    YAYVKRKIKV PHVGLPNILL GKEAVPELLQ HDAVPEKLAA ALADWYEHPD 350
    KVAALQQDFR VLHLLLKKDT ADLAARAVLE EAGC 384
    Length:384
    Mass (Da):42,472
    Last modified:October 1, 2000 - v1
    Checksum:iDB16882AB72FD304
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07388.1.
    PIRiD81998.
    RefSeqiYP_002341621.1. NC_003116.1.

    Genome annotation databases

    EnsemblBacteriaiCAM07388; CAM07388; NMA0069.
    GeneIDi906084.
    KEGGinma:NMA0069.
    PATRICi20360693. VBINeiMen132687_0082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07388.1 .
    PIRi D81998.
    RefSeqi YP_002341621.1. NC_003116.1.

    3D structure databases

    ProteinModelPortali Q9JX45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122587.NMA0069.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM07388 ; CAM07388 ; NMA0069 .
    GeneIDi 906084.
    KEGGi nma:NMA0069.
    PATRICi 20360693. VBINeiMen132687_0082.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi RRSEIRH.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci NMEN122587:GI3Q-63-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z2491.

    Entry informationi

    Entry nameiLPXB_NEIMA
    AccessioniPrimary (citable) accession number: Q9JX45
    Secondary accession number(s): A1INT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3