Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9JX45 (LPXB_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:NMA0069
OrganismNeisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]
Taxonomic identifier122587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190171

Sequences

Sequence LengthMass (Da)Tools
Q9JX45 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: DB16882AB72FD304

FASTA38442,472
        10         20         30         40         50         60 
MADKKSPLIA VSVGEASGDL LGAHLIRAIR KRCPQARFVG IGGELMKAEG FESLYDQERL 

        70         80         90        100        110        120 
AVRGFVEVVR RLPEILRIRR GLVRDLLSLK PDVFVGIDAP DFNLGVAERL KRSGIPTVHY 

       130        140        150        160        170        180 
VSPSVWAWRR ERVGKIVHQV NRVLCLFPME PQLYLDAGGR AEFVGHPMAQ LMPLEDDRET 

       190        200        210        220        230        240 
ARKTLGVDAG IPVFALLPGS RVSEIDYMAP VFFQTALLLL KRYPAARFLL PAATEATKRR 

       250        260        270        280        290        300 
LAEILQRSEF AGLPLTVTDR QSETVCRAAD AVLVTSGTAT LEVALCKRPM VISYKISPLT 

       310        320        330        340        350        360 
YAYVKRKIKV PHVGLPNILL GKEAVPELLQ HDAVPEKLAA ALADWYEHPD KVAALQQDFR 

       370        380 
VLHLLLKKDT ADLAARAVLE EAGC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157959 Genomic DNA. Translation: CAM07388.1.
PIRD81998.
RefSeqYP_002341621.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JX45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122587.NMA0069.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM07388; CAM07388; NMA0069.
GeneID906084.
KEGGnma:NMA0069.
PATRIC20360693. VBINeiMen132687_0082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMARRSEIRH.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycNMEN122587:GI3Q-63-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_NEIMA
AccessionPrimary (citable) accession number: Q9JX45
Secondary accession number(s): A1INT1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways