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Q9JWN9

- GLMS_NEIMA

UniProt

Q9JWN9 - GLMS_NEIMA

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei607 – 6071For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciNMEN122587:GI3Q-269-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:NMA0276
    OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
    Taxonomic identifieri122587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000626: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135360Add
    BLAST

    Proteomic databases

    PRIDEiQ9JWN9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi122587.NMA0276.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JWN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 220219Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini288 – 428141SIS 1UniRule annotationAdd
    BLAST
    Domaini461 – 602142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiGHKHTLA.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JWN9-1 [UniParc]FASTAAdd to Basket

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    MCGIVGAIRA HHNVVDFLTD GLKRLEYRGY DSSGIAVNTD GKIKRVRRVG    50
    RVQLMEDAAR EKGISGGIGI GHTRWATHGG VTEPNAHPHI SGGMIAVVHN 100
    GIIENFESER KRLEGLGYRF ESQTDTEVIA HSINHEYAQN GGKLFEAVQE 150
    AVKRFHGAYA IAVIAQDKPD ELVVARMGCP LLVALGDDET FIASDVSAVI 200
    AFTRRVAYLE DGDIALLASD GIKRLTDKSG LPAERKVKVS ELSLASLELG 250
    PYSHFMQKEI HEQPRAIADT AEVFLDGGFI PENFGKNAKS VFESIRSVKI 300
    LACGTSYYAA LTAKYWLESI AKIPSDVEIA SEYRYRSVIA DPDQLVITIS 350
    QSGETLDTME ALKYAKSLGH RHSLSICNVM ESALPRESSL VLYTRAGAEI 400
    GVASTKAFTT QLVALFGLAV TLAKVRGLVS EEDEARYTEE LRQLPGSVQH 450
    ALNLEPQIAA WAQQFAKKTS ALFLGRGIHY PIALEGALKL KEITYIHAEA 500
    YPAGELKHGP LALVDENMPV VVIAPNDSLL DKVKANMQEV GARGGELFVF 550
    ADLDSNFNAT EGVHVIRAPR HVGELSPVVH TIPVQLLSYH VALARGTDVD 600
    KPRNLAKSVT VE 612
    Length:612
    Mass (Da):66,572
    Last modified:January 23, 2007 - v3
    Checksum:i766139FE12252D5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07583.1.
    PIRiH82022.
    RefSeqiYP_002341803.1. NC_003116.1.

    Genome annotation databases

    EnsemblBacteriaiCAM07583; CAM07583; NMA0276.
    GeneIDi906285.
    KEGGinma:NMA0276.
    PATRICi20361190. VBINeiMen132687_0320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07583.1 .
    PIRi H82022.
    RefSeqi YP_002341803.1. NC_003116.1.

    3D structure databases

    ProteinModelPortali Q9JWN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122587.NMA0276.

    Proteomic databases

    PRIDEi Q9JWN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM07583 ; CAM07583 ; NMA0276 .
    GeneIDi 906285.
    KEGGi nma:NMA0276.
    PATRICi 20361190. VBINeiMen132687_0320.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi GHKHTLA.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci NMEN122587:GI3Q-269-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z2491.

    Entry informationi

    Entry nameiGLMS_NEIMA
    AccessioniPrimary (citable) accession number: Q9JWN9
    Secondary accession number(s): A1IPC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3