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Q9JWI7 (BICOA_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional enzyme BirA/CoaX

Including the following 2 domains:

  1. Biotin--[acetyl-CoA-carboxylase] synthetase
    EC=6.3.4.15
    Alternative name(s):
    Biotin--protein ligase
  2. Type III pantothenate kinase
    EC=2.7.1.33
    Alternative name(s):
    PanK-III
    Pantothenic acid kinase
Gene names
Name:birA/coaX
Ordered Locus Names:NMA0357
OrganismNeisseria meningitidis serogroup A [Complete proteome] [HAMAP]
Taxonomic identifier65699 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins By similarity. HAMAP MF_01274

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis By similarity. HAMAP MF_01274

Catalytic activity

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. HAMAP MF_01274

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_01274

Cofactor

Monovalent cations By similarity. HAMAP MF_01274

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_01274

Subcellular location

Cytoplasm Potential HAMAP MF_01274.

Sequence similarities

In the N-terminal section; belongs to the biotin--protein ligase family.

In the C-terminal section; belongs to the type III pantothenate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592Bifunctional enzyme BirA/CoaX HAMAP MF_01274
PRO_0000270883

Regions

Nucleotide binding344 – 3518ATP By similarity
Region1 – 329329Biotin--protein ligase HAMAP MF_01274
Region336 – 592257Type III pantothenate kinase HAMAP MF_01274
Region433 – 4364Substrate binding By similarity

Sites

Active site4351Proton acceptor Potential
Binding site4261Substrate By similarity
Binding site4581ATP Potential
Binding site5081Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JWI7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7ED2E0CD3B31C630

FASTA59264,469
        10         20         30         40         50         60 
MTVLKPSHWR VLAELADGLP QHVSQLARMA DMKPQQLNGF WQQMPAHIRG LLRQHDGYWR 

        70         80         90        100        110        120 
LVRPLAVFDA EGLRELGERS GFQTALKHEC ASSNDEILEL ARIAPDKAHK TICVTHLQSK 

       130        140        150        160        170        180 
GRGRQGRKWS HRLGECLMFS FGWVFDRPQY ELGSLSPVAA VACRRALSRL GLKTQIKWPN 

       190        200        210        220        230        240 
DLVVGRDKLG GILIETVRTG GKTVAVVGIG INFVLPKEVE NAASVQSLFQ TASRRGNADA 

       250        260        270        280        290        300 
AVLLETLLAE LDAVLLQYAR DGFAPFVAEY QAANRDHGKA VLLLRDGETV FEGTVKGVDG 

       310        320        330        340        350        360 
QGVLHLETAE GKQTVVSGEI SLRSDDRPVS VPKRRDSERF LLLDGGNSRL KWAWVENGTF 

       370        380        390        400        410        420 
ATVGSAPYRD LSPLGAEWAE KVDGNVRIVG CAVCGEFKKA QVQEQLARKI EWLPSSAQAL 

       430        440        450        460        470        480 
GIRNHYRHPE EHGSDRWFNA LGSRRFSRNA CVVVSCGTAV TVDALTDDGH YLGGTIMPGF 

       490        500        510        520        530        540 
HLMKESLAVR TANLNRHAGK RYPFPTTTGN AVASGMMDAV CGSVMMMHGR LKEKTGAGKP 

       550        560        570        580        590 
VDVIITGGGA AKVAEALPPA FLAENTVRVA DNLVIHGLLN LIAAEGGESE HT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL157959 Genomic DNA. Translation: CAM07655.1.
PIRH82031.
RefSeqYP_002341868.1. NC_003116.1.

3D structure databases

HSSPHSSP built from PDB template 1BIA based on UniProtKB P06709.
ProteinModelPortalQ9JWI7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000001903; EBNEIP00000001903; EBNEIG00000001903.
GeneID906361.
GenomeReviewsGene locus NMA0357 in contig AL157959_GR.
KEGGnma:NMA0357.
PATRIC20361386. VBINeiMen132687_0415.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000020654.
HOGENOMHBG576203.
OMAHECASSN.
ProtClustDBPRK13325.

Enzyme and pathway databases

BioCycNMEN122587:NMA0357-MONOMER.

Family and domain databases

HAMAPMF_01274. Pantothen_kinase_3. Fused.
[Tree]
InterProIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LipA_LipB.
IPR008988. Transcriptional_repressor_C.
IPR004619. Type_III_PanK.
[Graphical view]
KOK01947.
PANTHERPTHR12835. BirA_ligase. 1 hit.
PfamPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF03309. Bvg_acc_factor. 1 hit.
[Graphical view]
SUPFAMSSF50037. Transcr_rep_C. 1 hit.
TIGRFAMsTIGR00671. Baf. 1 hit.
TIGR00121. BirA_ligase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBICOA_NEIMA
AccessionPrimary (citable) accession number: Q9JWI7
Secondary accession number(s): A1IPI6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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