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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417ATP8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbA (EC:3.6.3.-)
Gene namesi
Name:msbA
Ordered Locus Names:NMA0535
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalAdd BLAST21
Transmembranei91 – 111HelicalAdd BLAST21
Transmembranei192 – 212HelicalAdd BLAST21
Transmembranei286 – 306HelicalAdd BLAST21
Transmembranei312 – 332HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925891 – 621Lipid A export ATP-binding/permease protein MsbAAdd BLAST621

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ9JW59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 344ABC transmembrane type-1Add BLAST313
Domaini378 – 611ABC transporterAdd BLAST234

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JW59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKLTFGLF KKEDARSFMR LMAYVRPYKI RIVAALIAIF GVAATESYLA
60 70 80 90 100
AFIAPLINHG FSAPAAPPEL SAAAGILSTL QNWREQFTYM VWGTENKIWT
110 120 130 140 150
VPLFLIILVV IRGICRFTST YLMTWVSVMT ISKIRKDMFA KMLTLSSRYH
160 170 180 190 200
QETPSGTVLM NMLNLTEQSV SNASDIFTVL TRDTMIVTGL TIVLLYLNWQ
210 220 230 240 250
LSLIVVLMFP LLSLLSRYYR DRLKHVISDS QKSIGTMNNV IAETHQGHRV
260 270 280 290 300
VKLFNGQAQA ANRFDAINRT IVRLSKKITQ ATAAHSPFSE LIASIALAVV
310 320 330 340 350
IFIALWQSQN GYTTIGEFMA FIVAMLQMYA PIKSLANISI PMQTMFLAAD
360 370 380 390 400
GVCAFLDTPP EQDKGTLAPQ RVEGRISFRN VDVEYRSDGI KALDGFNLDI
410 420 430 440 450
RQGERVALVG RSGSGKSTVV NLLPRFVEPS AGNICIDGID IADIKLDCLR
460 470 480 490 500
AQFALVSQDV FLFDDTLFEN VRYSRPDAGE AEVLSALQAA NLQSLIDASP
510 520 530 540 550
LGLHQPIGSN GSNLSGGQRQ RVAIARAILK DAPILLLDEA TSALDNESER
560 570 580 590 600
LVQQALERLM ENRTGIIVAH RLTTIEGADR IIVMDDGKII EQGTHEQLMS
610 620
QNGYYTMLRN ISNKDAAVRT A
Length:621
Mass (Da):68,754
Last modified:October 1, 2000 - v1
Checksum:iA1B06D20348F9A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM07812.1.
PIRiH81971.
RefSeqiWP_002247090.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM07812; CAM07812; NMA0535.
KEGGinma:NMA0535.

Similar proteinsi

Entry informationi

Entry nameiMSBA_NEIMA
AccessioniPrimary (citable) accession number: Q9JW59
Secondary accession number(s): A1IPY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families