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Q9JW39 (SYL_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:NMA0559
OrganismNeisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]
Taxonomic identifier122587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152053

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif668 – 6725"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6711ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JW39 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0609FDE0E39C0DE6

FASTA910101,506
        10         20         30         40         50         60 
MQEQYQPAAI EPAAQKKWDD ARIFNVSEDA SKPKYYCLSM FPYPSGKLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VLSRFKLLNG FNVMQPMGWD AFGMPAENAA MKNNVAPAAW TYDNIEYMKT QLKSLGFAID 

       130        140        150        160        170        180 
WARETATCKP EYYRWEQWLF TKLFEKGIVY RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG 

       190        200        210        220        230        240 
ALIEKREIPM YYFKITDYAE ELLNDLDKLE HWPEQVKTMQ RNWIGKSRGM TVRFAVSDDS 

       250        260        270        280        290        300 
KQGLEGDYAK FLQVYTTRPD TLMGATYVAV AAEHPLATAA AADKPELQAF IAECKAGSVA 

       310        320        330        340        350        360 
EADMATMEKK GVPTGRYVVN PLNGDKLEVW IANYVLWGYG DGAVMAVPAH DERDFEFAAK 

       370        380        390        400        410        420 
YSLPKKQVLQ RVTIGLSPEQ EEAMGFGGGS GCGAGYGDGS GSDSRDLPFM PNKWQAWYGV 

       430        440        450        460        470        480 
KDDFMVLINS GELDGMNYQT AFDAVAAKLQ AIGAGEPKTQ YRLRDWGISR QRYWGCPIPI 

       490        500        510        520        530        540 
VHCEQCGDVP VPADQLPVVL PENVVPDGMG SPLAKMPEFY ETTCPCCGGA AKRETDTMDT 

       550        560        570        580        590        600 
FMESSWYFFR YMSPKFSDGM VDPAAAKYWG AVDQYIGGIE HAILHLLYAR FFTKLMRDEG 

       610        620        630        640        650        660 
LVNVDEPFER LLTQGMVVCE TYYRENDKGG KDWINPADVE LTFDDKGRPV SAVLKVDGLP 

       670        680        690        700        710        720 
VVISGTEKMS KSKNNGVDPQ ELINAYGADT ARLFMMFAAP PEQSLEWSDS GVEGAHRFLR 

       730        740        750        760        770        780 
RLWRTVYEYL KQGEAVNAFA GSQDGLSKEL KDLRHKLHST IAKVSDDYGR RQQFNTAIAA 

       790        800        810        820        830        840 
VMELLNQYDK TDTGSEQGRT VAQEVLEAAV RLLWPIVPHI CETLWSELNG AKLWEAGWPA 

       850        860        870        880        890        900 
VDEAALVKSE IEVMVQVNGK LRGKITVAAD ASKADLEAAA LATEGAVKFM EGKPAKKIIV 

       910 
VPGRLVNIVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157959 Genomic DNA. Translation: CAM07834.1.
PIRF81974.
RefSeqYP_002342041.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JW39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122587.NMA0559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM07834; CAM07834; NMA0559.
GeneID906553.
KEGGnma:NMA0559.
PATRIC20361886. VBINeiMen132687_0659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAVVHCDAC.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycNMEN122587:GI3Q-529-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_NEIMA
AccessionPrimary (citable) accession number: Q9JW39
Secondary accession number(s): A1IQ09
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries