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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei671ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NMA0559
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520531 – 910Leucine--tRNA ligaseAdd BLAST910

Proteomic databases

PRIDEiQ9JW39

Structurei

3D structure databases

ProteinModelPortaliQ9JW39
SMRiQ9JW39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi668 – 672"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JW39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYQPAAI EPAAQKKWDD ARIFNVSEDA SKPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRFKLLNG FNVMQPMGWD AFGMPAENAA MKNNVAPAAW
110 120 130 140 150
TYDNIEYMKT QLKSLGFAID WARETATCKP EYYRWEQWLF TKLFEKGIVY
160 170 180 190 200
RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITDYAE
210 220 230 240 250
ELLNDLDKLE HWPEQVKTMQ RNWIGKSRGM TVRFAVSDDS KQGLEGDYAK
260 270 280 290 300
FLQVYTTRPD TLMGATYVAV AAEHPLATAA AADKPELQAF IAECKAGSVA
310 320 330 340 350
EADMATMEKK GVPTGRYVVN PLNGDKLEVW IANYVLWGYG DGAVMAVPAH
360 370 380 390 400
DERDFEFAAK YSLPKKQVLQ RVTIGLSPEQ EEAMGFGGGS GCGAGYGDGS
410 420 430 440 450
GSDSRDLPFM PNKWQAWYGV KDDFMVLINS GELDGMNYQT AFDAVAAKLQ
460 470 480 490 500
AIGAGEPKTQ YRLRDWGISR QRYWGCPIPI VHCEQCGDVP VPADQLPVVL
510 520 530 540 550
PENVVPDGMG SPLAKMPEFY ETTCPCCGGA AKRETDTMDT FMESSWYFFR
560 570 580 590 600
YMSPKFSDGM VDPAAAKYWG AVDQYIGGIE HAILHLLYAR FFTKLMRDEG
610 620 630 640 650
LVNVDEPFER LLTQGMVVCE TYYRENDKGG KDWINPADVE LTFDDKGRPV
660 670 680 690 700
SAVLKVDGLP VVISGTEKMS KSKNNGVDPQ ELINAYGADT ARLFMMFAAP
710 720 730 740 750
PEQSLEWSDS GVEGAHRFLR RLWRTVYEYL KQGEAVNAFA GSQDGLSKEL
760 770 780 790 800
KDLRHKLHST IAKVSDDYGR RQQFNTAIAA VMELLNQYDK TDTGSEQGRT
810 820 830 840 850
VAQEVLEAAV RLLWPIVPHI CETLWSELNG AKLWEAGWPA VDEAALVKSE
860 870 880 890 900
IEVMVQVNGK LRGKITVAAD ASKADLEAAA LATEGAVKFM EGKPAKKIIV
910
VPGRLVNIVV
Length:910
Mass (Da):101,506
Last modified:October 1, 2000 - v1
Checksum:i0609FDE0E39C0DE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM07834.1
PIRiF81974
RefSeqiWP_002246442.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM07834; CAM07834; NMA0559
KEGGinma:NMA0559

Entry informationi

Entry nameiSYL_NEIMA
AccessioniPrimary (citable) accession number: Q9JW39
Secondary accession number(s): A1IQ09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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