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Q9JW13

- DXS_NEIMA

UniProt

Q9JW13 - DXS_NEIMA

Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761Thiamine pyrophosphateUniRule annotation
    Metal bindingi148 – 1481MagnesiumUniRule annotation
    Metal bindingi177 – 1771MagnesiumUniRule annotation
    Binding sitei177 – 1771Thiamine pyrophosphateUniRule annotation
    Binding sitei294 – 2941Thiamine pyrophosphateUniRule annotation
    Binding sitei381 – 3811Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Thiamine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciNMEN122587:GI3Q-555-MONOMER.
    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthaseUniRule annotation
    Short name:
    DXP synthaseUniRule annotation
    Short name:
    DXPSUniRule annotation
    Gene namesi
    Name:dxsUniRule annotation
    Ordered Locus Names:NMA0589
    OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
    Taxonomic identifieri122587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000626: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6376371-deoxy-D-xylulose-5-phosphate synthasePRO_0000189133Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi122587.NMA0589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JW13.
    SMRiQ9JW13. Positions 1-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1193Thiamine pyrophosphate bindingUniRule annotation
    Regioni149 – 1502Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    HOGENOMiHOG000012988.
    KOiK01662.
    OMAiAATCETF.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JW13-1 [UniParc]FASTAAdd to Basket

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    MNPSPLLDLI DSPQDLRRLD KKQLPRLAGE LRTFLLESVG QTGGHFASNL    50
    GAVELTVALH YVYNTPEDKL VWDVGHQSYP HKILTGRKNQ MHTMRQYGGL 100
    AGFPKRCESE YDAFGVGHSS TSIGAALGMA AADKQLGSDR RSVAIIGDGA 150
    MTAGQAFEAL NCAGDMDVDL LVVLNDNEMS ISPNVGALPK YLASNVVRDM 200
    HGLLSTVKAQ TGKVLDKIPG AMEFAQKVEH KIKTLAEEAE HAKQSLSLFE 250
    NFGFRYTGPV DGHNVENLVD VLEDLRGRKG PQLLHVITKK GNGYKLAEND 300
    PVKYHAVANL PKESAAQMPS EKEPKPAAKP TYTQVFGKWL CDRAAADSRL 350
    VAITPAMREG SGLVEFEQRF PDRYFDVGIA EQHAVTFAGG LACEGMKPVV 400
    AIYSTFLQRA YDQLVHDIAL QNLPVLFAVD RAGIVGADGP THAGLYDLSF 450
    LRCIPNMIVA APSDENECRL LLSTCYQADA PAAVRYPRGT GTGVPVSDGM 500
    ETVEIGKGII RREGEKTAFI AFGSMVAPAL AVAGKLNATV ADMRFVKPID 550
    EELIVRLARS HDRIVTLEEN AEQGGAGSAV LEVLAKHGIC KPVLLLGVAD 600
    TVTGHGDPKK LLDDLGLSAE AVERRVRAWL SDRDAAN 637
    Length:637
    Mass (Da):68,720
    Last modified:October 1, 2000 - v1
    Checksum:i3B2BBD01AAD182F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07859.1.
    PIRiB81978.
    RefSeqiYP_002342065.1. NC_003116.1.

    Genome annotation databases

    EnsemblBacteriaiCAM07859; CAM07859; NMA0589.
    GeneIDi906582.
    KEGGinma:NMA0589.
    PATRICi20361956. VBINeiMen132687_0693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM07859.1 .
    PIRi B81978.
    RefSeqi YP_002342065.1. NC_003116.1.

    3D structure databases

    ProteinModelPortali Q9JW13.
    SMRi Q9JW13. Positions 1-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122587.NMA0589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM07859 ; CAM07859 ; NMA0589 .
    GeneIDi 906582.
    KEGGi nma:NMA0589.
    PATRICi 20361956. VBINeiMen132687_0693.

    Phylogenomic databases

    eggNOGi COG1154.
    HOGENOMi HOG000012988.
    KOi K01662.
    OMAi AATCETF.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .
    BioCyci NMEN122587:GI3Q-555-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z2491.

    Entry informationi

    Entry nameiDXS_NEIMA
    AccessioniPrimary (citable) accession number: Q9JW13
    Secondary accession number(s): A1IQ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3