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Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi: 1-deoxy-D-xylulose 5-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 1-deoxy-D-xylulose-5-phosphate synthase (dxs)
This subpathway is part of the pathway 1-deoxy-D-xylulose 5-phosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate, the pathway 1-deoxy-D-xylulose 5-phosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76Thiamine pyrophosphateUniRule annotation1
Metal bindingi148MagnesiumUniRule annotation1
Metal bindingi177MagnesiumUniRule annotation1
Binding sitei177Thiamine pyrophosphateUniRule annotation1
Binding sitei294Thiamine pyrophosphateUniRule annotation1
Binding sitei381Thiamine pyrophosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Thiamine biosynthesis
LigandMagnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciNMEN122587:G1G1G-656-MONOMER
UniPathwayiUPA00064; UER00091

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthaseUniRule annotation
Short name:
DXP synthaseUniRule annotation
Short name:
DXPSUniRule annotation
Gene namesi
Name:dxsUniRule annotation
Ordered Locus Names:NMA0589
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001891331 – 6371-deoxy-D-xylulose-5-phosphate synthaseAdd BLAST637

Proteomic databases

PRIDEiQ9JW13

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9JW13
SMRiQ9JW13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 119Thiamine pyrophosphate bindingUniRule annotation3
Regioni149 – 150Thiamine pyrophosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012988
KOiK01662
OMAiAINHAGH

Family and domain databases

CDDicd02007 TPP_DXS, 1 hit
Gene3Di3.40.50.920, 1 hit
HAMAPiMF_00315 DXP_synth, 1 hit
InterProiView protein in InterPro
IPR005477 Dxylulose-5-P_synthase
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR005474 Transketolase_N
PANTHERiPTHR43322 PTHR43322, 1 hit
PfamiView protein in Pfam
PF13292 DXP_synthase_N, 1 hit
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 3 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00204 dxs, 1 hit
PROSITEiView protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit
PS00802 TRANSKETOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JW13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSPLLDLI DSPQDLRRLD KKQLPRLAGE LRTFLLESVG QTGGHFASNL
60 70 80 90 100
GAVELTVALH YVYNTPEDKL VWDVGHQSYP HKILTGRKNQ MHTMRQYGGL
110 120 130 140 150
AGFPKRCESE YDAFGVGHSS TSIGAALGMA AADKQLGSDR RSVAIIGDGA
160 170 180 190 200
MTAGQAFEAL NCAGDMDVDL LVVLNDNEMS ISPNVGALPK YLASNVVRDM
210 220 230 240 250
HGLLSTVKAQ TGKVLDKIPG AMEFAQKVEH KIKTLAEEAE HAKQSLSLFE
260 270 280 290 300
NFGFRYTGPV DGHNVENLVD VLEDLRGRKG PQLLHVITKK GNGYKLAEND
310 320 330 340 350
PVKYHAVANL PKESAAQMPS EKEPKPAAKP TYTQVFGKWL CDRAAADSRL
360 370 380 390 400
VAITPAMREG SGLVEFEQRF PDRYFDVGIA EQHAVTFAGG LACEGMKPVV
410 420 430 440 450
AIYSTFLQRA YDQLVHDIAL QNLPVLFAVD RAGIVGADGP THAGLYDLSF
460 470 480 490 500
LRCIPNMIVA APSDENECRL LLSTCYQADA PAAVRYPRGT GTGVPVSDGM
510 520 530 540 550
ETVEIGKGII RREGEKTAFI AFGSMVAPAL AVAGKLNATV ADMRFVKPID
560 570 580 590 600
EELIVRLARS HDRIVTLEEN AEQGGAGSAV LEVLAKHGIC KPVLLLGVAD
610 620 630
TVTGHGDPKK LLDDLGLSAE AVERRVRAWL SDRDAAN
Length:637
Mass (Da):68,720
Last modified:October 1, 2000 - v1
Checksum:i3B2BBD01AAD182F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM07859.1
PIRiB81978
RefSeqiWP_002247120.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM07859; CAM07859; NMA0589
KEGGinma:NMA0589

Similar proteinsi

Entry informationi

Entry nameiDXS_NEIMA
AccessioniPrimary (citable) accession number: Q9JW13
Secondary accession number(s): A1IQ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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