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Q9JW13

- DXS_NEIMA

UniProt

Q9JW13 - DXS_NEIMA

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Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Thiamine pyrophosphateUniRule annotation
Metal bindingi148 – 1481MagnesiumUniRule annotation
Metal bindingi177 – 1771MagnesiumUniRule annotation
Binding sitei177 – 1771Thiamine pyrophosphateUniRule annotation
Binding sitei294 – 2941Thiamine pyrophosphateUniRule annotation
Binding sitei381 – 3811Thiamine pyrophosphateUniRule annotation

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Thiamine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-555-MONOMER.
UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthaseUniRule annotation
Short name:
DXP synthaseUniRule annotation
Short name:
DXPSUniRule annotation
Gene namesi
Name:dxsUniRule annotation
Ordered Locus Names:NMA0589
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6376371-deoxy-D-xylulose-5-phosphate synthasePRO_0000189133Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi122587.NMA0589.

Structurei

3D structure databases

ProteinModelPortaliQ9JW13.
SMRiQ9JW13. Positions 1-631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1193Thiamine pyrophosphate bindingUniRule annotation
Regioni149 – 1502Thiamine pyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1154.
HOGENOMiHOG000012988.
KOiK01662.
OMAiAATCETF.
OrthoDBiEOG6BKJ6P.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JW13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPSPLLDLI DSPQDLRRLD KKQLPRLAGE LRTFLLESVG QTGGHFASNL
60 70 80 90 100
GAVELTVALH YVYNTPEDKL VWDVGHQSYP HKILTGRKNQ MHTMRQYGGL
110 120 130 140 150
AGFPKRCESE YDAFGVGHSS TSIGAALGMA AADKQLGSDR RSVAIIGDGA
160 170 180 190 200
MTAGQAFEAL NCAGDMDVDL LVVLNDNEMS ISPNVGALPK YLASNVVRDM
210 220 230 240 250
HGLLSTVKAQ TGKVLDKIPG AMEFAQKVEH KIKTLAEEAE HAKQSLSLFE
260 270 280 290 300
NFGFRYTGPV DGHNVENLVD VLEDLRGRKG PQLLHVITKK GNGYKLAEND
310 320 330 340 350
PVKYHAVANL PKESAAQMPS EKEPKPAAKP TYTQVFGKWL CDRAAADSRL
360 370 380 390 400
VAITPAMREG SGLVEFEQRF PDRYFDVGIA EQHAVTFAGG LACEGMKPVV
410 420 430 440 450
AIYSTFLQRA YDQLVHDIAL QNLPVLFAVD RAGIVGADGP THAGLYDLSF
460 470 480 490 500
LRCIPNMIVA APSDENECRL LLSTCYQADA PAAVRYPRGT GTGVPVSDGM
510 520 530 540 550
ETVEIGKGII RREGEKTAFI AFGSMVAPAL AVAGKLNATV ADMRFVKPID
560 570 580 590 600
EELIVRLARS HDRIVTLEEN AEQGGAGSAV LEVLAKHGIC KPVLLLGVAD
610 620 630
TVTGHGDPKK LLDDLGLSAE AVERRVRAWL SDRDAAN
Length:637
Mass (Da):68,720
Last modified:October 1, 2000 - v1
Checksum:i3B2BBD01AAD182F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM07859.1.
PIRiB81978.
RefSeqiYP_002342065.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM07859; CAM07859; NMA0589.
GeneIDi906582.
KEGGinma:NMA0589.
PATRICi20361956. VBINeiMen132687_0693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM07859.1 .
PIRi B81978.
RefSeqi YP_002342065.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JW13.
SMRi Q9JW13. Positions 1-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA0589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM07859 ; CAM07859 ; NMA0589 .
GeneIDi 906582.
KEGGi nma:NMA0589.
PATRICi 20361956. VBINeiMen132687_0693.

Phylogenomic databases

eggNOGi COG1154.
HOGENOMi HOG000012988.
KOi K01662.
OMAi AATCETF.
OrthoDBi EOG6BKJ6P.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .
BioCyci NMEN122587:GI3Q-555-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiDXS_NEIMA
AccessioniPrimary (citable) accession number: Q9JW13
Secondary accession number(s): A1IQ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3