Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9JVZ6 (CARA_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain
EC=6.3.5.5
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain
Gene names
Name:carA
Ordered Locus Names:NMA0608
OrganismNeisseria meningitidis serogroup A [Complete proteome] [HAMAP]
Taxonomic identifier65699 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP MF_01209

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.

Sequence similarities

Belongs to the CarA family.

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Carbamoyl-phosphate synthase small chain HAMAP MF_01209
PRO_0000112298

Regions

Domain190 – 377188Glutamine amidotransferase type-1
Region1 – 186186CPSase HAMAP MF_01209

Sites

Active site2661Nucleophile By similarity
Active site3501 By similarity
Active site3521 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JVZ6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1C64175800E26272

FASTA37740,605
        10         20         30         40         50         60 
MSTPALLVLA DGSVFHGTSI GYEGSTSGEV VFNTSMTGYQ EILTDPSYCK QIVTLTYPHI 

        70         80         90        100        110        120 
GNTGTNAEDE ESRSVYAAGL IIRDLPLLHS NFRASESLHD YLVRNKTVAI ADIDTRRLTT 

       130        140        150        160        170        180 
LLREKGAQGG AILTGADATI EKAQELIAAF GSMVGKDLAK EVSCTETYEW TEGEWALGKG 

       190        200        210        220        230        240 
FVTPDEQPYH VVAYDFGVKT NILRMLASRG CRLTVVPAQT SAQDVLALNP DGVFLSNGPG 

       250        260        270        280        290        300 
DPEPCTYAIE AVQKLMESGK PIFGICLGHQ LISLAIGAKT LKMRFSHHGA NHPVQDLDSG 

       310        320        330        340        350        360 
KVVITSQNHG FAVDADTLPA NARITHKSLF DNTLQGIELT DKPVFCFQGH PEASPGPQDV 

       370 
GYLFDKFIGN MKAAKRA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL157959 Genomic DNA. Translation: CAM07875.1.
PIRD81980.
RefSeqYP_002342081.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JVZ6.
SMRQ9JVZ6. Positions 5-368.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000000591; EBNEIP00000000591; EBNEIG00000000591.
GeneID906603.
GenomeReviewsGene locus NMA0608 in contig AL157959_GR.
KEGGnma:NMA0608.
PATRIC20361998. VBINeiMen132687_0714.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000020378.
HOGENOMHBG286341.
OMAFTYPELG.
ProtClustDBPRK12564.

Enzyme and pathway databases

BioCycNMEN122587:NMA0608-MONOMER.

Family and domain databases

HAMAPMF_01209. CPSase_S_chain.
[Tree]
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
Gene3DG3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit.
KOK01956.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCARA_NEIMA
AccessionPrimary (citable) accession number: Q9JVZ6
Secondary accession number(s): A1IQ49
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents