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Q9JVT3 (NAGZ_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:NMA0708
OrganismNeisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]
Taxonomic identifier122587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000210790

Regions

Region174 – 1752Substrate binding By similarity

Sites

Active site1871Proton donor/acceptor By similarity
Active site2581Nucleophile By similarity
Binding site691Substrate By similarity
Binding site771Substrate By similarity
Binding site1441Substrate By similarity
Site1851Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JVT3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 174F048B59CAAFBC

FASTA36139,023
        10         20         30         40         50         60 
MTVPCIPRGP VMADIAAFRL TEEEKQRLLD PAVGGVILFR RNFQNIAQLK ELTAEIKALR 

        70         80         90        100        110        120 
TPELIIAVDH EGGRVQRFIE GFTRLPAMNV LGQIWDKDGA SAAETAARQI GWVLATELSA 

       130        140        150        160        170        180 
CGIDLSFTPV LDLDWGNCAV IGNRSFHRNP EAVARLALAL QKGLEKGGMK SCGKHFPGHG 

       190        200        210        220        230        240 
FVEGDSHLVL PEDGRSLSEL EAADLAPFRI MSREGMAAVM PAHVVYPQVD TKPAGFSEIW 

       250        260        270        280        290        300 
LKQILRRDIG FKGVIFSDDL TMEGACGAGG IKERARISFE AGCDIVLVCN RPDLVDELRD 

       310        320        330        340        350        360 
DFRIPDNPAL AQRWQYMANT LGSAAAQAVI QTADFQAAQA FVAGLASPQD TAGGVKVGEA 


F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157959 Genomic DNA. Translation: CAM07963.1.
PIRH81913.
RefSeqYP_002342164.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JVT3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122587.NMA0708.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM07963; CAM07963; NMA0708.
GeneID906701.
KEGGnma:NMA0708.
PATRIC20362260. VBINeiMen132687_0844.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAAGFSSYW.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

BioCycNMEN122587:GI3Q-661-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_NEIMA
AccessionPrimary (citable) accession number: Q9JVT3
Secondary accession number(s): A1IQD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries