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Q9JV35

- GCH4_NEIMA

UniProt

Q9JV35 - GCH4_NEIMA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei188 – 1881May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-938-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:NMA1013
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_0000147715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi122587.NMA1013.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JV35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLLKASDII SHLQIDGIFP GGNAIPCTHL NNYMNIKEKQ LMNTIADVQS
60 70 80 90 100
SRDLRNLPIN QVGIKDLRFP ITLQTAEGIQ STVARLTMTV YLPAEQKGTH
110 120 130 140 150
MSRFVALMEQ HTEALDFAQL RRLTAEMVAL LDSRAGKISV SFPFFRKKTA
160 170 180 190 200
PVSGIRSLLD YDVSLTGEMK DGAYGHSMKV MIPVTSLCPC SKEISQYGAH
210 220 230 240 250
NQRSHVTVSL TADAEVGIEE VIDYVEAQAS CQLYGLLKRP DEKYVTEKAY
260 270 280 290
ENPKFVEDMV RDVATSLIAD KRIKSFVVES ENFESIHNHS AYAYIAYP
Length:298
Mass (Da):33,296
Last modified:May 5, 2009 - v2
Checksum:i0BF4D3CECF112242
GO

Sequence cautioni

The sequence CAM08235.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08235.1. Different initiation.
PIRiC81949.
RefSeqiYP_002342433.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08235; CAM08235; NMA1013.
GeneIDi906989.
KEGGinma:NMA1013.
PATRICi20362950. VBINeiMen132687_1184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08235.1 . Different initiation.
PIRi C81949.
RefSeqi YP_002342433.1. NC_003116.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA1013.

Protocols and materials databases

DNASUi 906989.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM08235 ; CAM08235 ; NMA1013 .
GeneIDi 906989.
KEGGi nma:NMA1013.
PATRICi 20362950. VBINeiMen132687_1184.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci NMEN122587:GI3Q-938-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiGCH4_NEIMA
AccessioniPrimary (citable) accession number: Q9JV35
Secondary accession number(s): A1IR51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 5, 2009
Last modified: October 1, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3