Q9JUV1 (PIP_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline iminopeptidase
Short name=PIP
EC=3.4.11.5

Alternative name(s):
Prolyl aminopeptidase
Short name=PAP

Gene names

Name:	pip
Ordered Locus Names:	NMA1122

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Proline iminopeptidase		PRO_0000080842
Sites
	Active site	107	1	Nucleophile By similarity
	Active site	260	1	By similarity
	Active site	287	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JUV1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9F888B54135478A1	FASTA	310	34,901
	10 20 30 40 50 60 MYEIKQPFHS GYLQVSEIHQ IYWEESGNPD GVPVIFLHGG PGAGASPECR GFFNPDVFRI 70 80 90 100 110 120 VIIDQRGCGR SRPYACAEDN TTWDLVADIE KVREMLGIGK WLVFGGSWGS TLSLAYAQTH 130 140 150 160 170 180 PERVKGLVLR GIFLCRPSET VWLNEAGGVS RIYPEQWQKF VAPIAENRRN QLIEAYHGLL 190 200 210 220 230 240 FHQDEEVCLS AAKAWADWES YLIRFEPEEV DEDAYASLAI ARLENHYFVN GGWLQGDRAI 250 260 270 280 290 300 LNNIGKIQHI PTIIVQGRYD LCTPMQSAWA LSKAFPEAEL RVVQAGHRAF DPPLVDALVQ 310 AVEDILPHLL

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157959 Genomic DNA. Translation: CAM08330.1.
PIR	F81878.
RefSeq	YP_002342525.1. NC_003116.1.
3D structure databases
ProteinModelPortal	Q9JUV1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000000239; EBNEIP00000000239; EBNEIG00000000239.
GeneID	907091.
GenomeReviews	Gene locus NMA1122 in contig AL157959_GR.
KEGG	nma:NMA1122.
PATRIC	20363200. VBINeiMen132687_1307.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020931.
HOGENOM	HBG677789.
OMA	AELDWYY.
ProtClustDB	CLSK877812.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA1122-MONOMER.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
KO	K01259.
PANTHER	PTHR10992:SF12. PTHR10992:SF12. 1 hit.
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00111. ABHYDROLASE. PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. Pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_NEIMA

Accession

Primary (citable) accession number: Q9JUV1
Secondary accession number(s): A1IRE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program