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Q9JUT6 (METE_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:NMA1140
OrganismNeisseria meningitidis serogroup A [Complete proteome] [HAMAP]
Taxonomic identifier65699 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7587585-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098643

Sites

Metal binding6431Zinc By similarity
Metal binding6451Zinc By similarity
Metal binding7281Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JUT6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 4EB8E707EEE88849

FASTA75885,122
        10         20         30         40         50         60 
MTTLHFSGFP RVGAFRELKF AQEKYWRKEI SEQELLAVAK DLREKNWKHQ AAANADYVAV 

        70         80         90        100        110        120 
GDFTFYDHIL DLQVATGAIP ARFGFDSQNL SLEQFFQLAR GNKDQFAIEM TKWFDTNYHY 

       130        140        150        160        170        180 
LVPEFHADTE FKANAKHYVQ QLQEAQALGL KAKPTVVGPL TFLWVGKEKG AVEFDRLSLL 

       190        200        210        220        230        240 
PKLLPVYVEI LTALVEAGAE WIQIDEPALT VDLPKEWVEA YKDVYATLSK VSAKILLSTY 

       250        260        270        280        290        300 
FGSVAEHAAL LKSLPVDGLH IDLVRAPEQL DAFADYDKVL SAGVIDGRNI WRANLNKVLE 

       310        320        330        340        350        360 
TVELLQAKLG DRLWISSSCS LLHTPFDLSV EEKLKANKPD LYSWLAFTLQ KTQELRVLKA 

       370        380        390        400        410        420 
ALNEGRDSVA EELAASQAAA DSRANSSEIH RADVAKRLAD LPANADQRKS PFADRIKAQQ 

       430        440        450        460        470        480 
AWLNLPLLPT TNIGSFPQTT EIRQARAAFK KGELSAADYE AAMKKEIALV VEEQEKLDLD 

       490        500        510        520        530        540 
VLVHGEAERN DMVEYFGELL SGFAFTQYGW VQSYGSRCVK PPIIFGDVSR PEAMTVAWST 

       550        560        570        580        590        600 
YAQSLTKRPM KGMLTGPVTI LQWSFVRNDI PRSTVCKQIA LALNDEVLDL EKAGIKVIQI 

       610        620        630        640        650        660 
DEPAIREGLP LKRADWDAYL NWAGESFRLS STGCEDSTQI HTHMCYSEFN DILPAIAAMD 

       670        680        690        700        710        720 
ADVITIETSR SDMELLTAFG EFKYPNDIGP GVYDIHSPRV PTEAEVEHLL RKAIEVVPVE 

       730        740        750 
RLWVNPDCGL KTRGWKETLE QLQVMMNVTH KLRAELAK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL157959 Genomic DNA. Translation: CAM08346.1.
PIRG81880.
RefSeqYP_002342541.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JUT6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000000180; EBNEIP00000000180; EBNEIG00000000180.
GeneID907109.
GenomeReviewsGene locus NMA1140 in contig AL157959_GR.
KEGGnma:NMA1140.
PATRIC20363242. VBINeiMen132687_1328.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000021045.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycNMEN122587:NMA1140-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_NEIMA
AccessionPrimary (citable) accession number: Q9JUT6
Secondary accession number(s): A1IRG0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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