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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciNMEN122587:G1G1G-1317-MONOMER
UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:NMA1182
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001921081 – 530Bifunctional purine biosynthesis protein PurHAdd BLAST530

Structurei

3D structure databases

ProteinModelPortaliQ9JUQ8
SMRiQ9JUQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147MGS-likePROSITE-ProRule annotationAdd BLAST147

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230373
KOiK00602
OMAiDLLFAWK

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
PROSITEiView protein in PROSITE
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JUQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSIKRALIS LSDKTGAVEF AQTLHKLGVE ILSTGGTAKL LADAGVPVIE
60 70 80 90 100
VADYTGFPEM LDGRVKTLHP KIHGGILGRR DLPEHVAKME EHGIGNIDLV
110 120 130 140 150
CVNLYPFAAT IAKPNCTLED AIENIDIGGP TMVRSAAKNW KHVAIVTDPA
160 170 180 190 200
DFPAIAAEME ANNGALSDKT RFNLSRKAFS HTAQYDGMIS NYLTSLSDDV
210 220 230 240 250
LSGTPEIGEF PSQFNQSWIK VQDMRYGENP HQRAAFYRDV YPAAGSLSAY
260 270 280 290 300
KQLQGKELSY NNIADADAAW EAVKSFDAPA CVIVKHANPC GVAVAADTLT
310 320 330 340 350
AYKLAYATDT TSAFGGIIAF NREVDGETVK QITDNQFMEV LMAPKFTAEA
360 370 380 390 400
LEIAAAKKNV RVLQISLTTP LEAGANRFEL KRVGGGLLVQ TPDIYRLNRA
410 420 430 440 450
DLKVVSKRQL TEQEWNDLMF VWNVAKYVKS NAIVFGKGGQ TYGIGAGQMS
460 470 480 490 500
RVDSTRIAAR KAQDANLDLN GACAASDAFF PFRDGVDVIA EQGIKAIIHP
510 520 530
AGSMRDQEVF DAADEHGIAM VVTGVRHFRH
Length:530
Mass (Da):57,435
Last modified:October 1, 2000 - v1
Checksum:i43704317F7B7610B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM08384.1
PIRiH81885
RefSeqiWP_002246828.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM08384; CAM08384; NMA1182
KEGGinma:NMA1182

Similar proteinsi

Entry informationi

Entry nameiPUR9_NEIMA
AccessioniPrimary (citable) accession number: Q9JUQ8
Secondary accession number(s): A1IRJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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