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Protein

Glucose-6-phosphate isomerase 1

Gene

pgi1

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 2 (pgi2)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorBy similarity
Active sitei384 – 3841By similarity
Active sitei512 – 5121By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1459-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 1 (EC:5.3.1.9)
Short name:
GPI 1
Alternative name(s):
Phosphoglucose isomerase 1
Short name:
PGI 1
Phosphohexose isomerase 1
Short name:
PHI 1
Gene namesi
Name:pgi1
Ordered Locus Names:NMA1604
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Glucose-6-phosphate isomerase 1PRO_0000180691Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9JTW1.
SMRiQ9JTW1. Positions 3-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JTW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLHDLPAW SKLWNHFDDS KTLHMREMFE QDPQRAERYW LQVGGLTLDY
60 70 80 90 100
SKNRINDETM SLLFELAHEA GVPERMRQMF HGKKINTTEN RAVLHVALRN
110 120 130 140 150
RTNSPIVVDG EDVMPKVNRV LQRMGEFAHE VRSGSWLGYT NQVITDVVNI
160 170 180 190 200
GIGGSDLGPL MMCTALKPFG HPRLNMHFVS NVDGSQLRDV LSKVHPETTL
210 220 230 240 250
FIIASKTFTT QETLTNALTA REWFLNHAGD EEAVAKHFAA VSTNQKAVAE
260 270 280 290 300
FGIDTANMFE FWDWVGGRYS LWSAIGLPIM LYLGEENFIE MLNGAHLMDQ
310 320 330 340 350
HFINTPLERN LPVILALIGI WYINYYGGGS HVIAPYDQHL HRLPKFIQQL
360 370 380 390 400
DMESNGKQVT LDGKAVGHET SPIIWGETGI NGQHAFFQLL HQGTHITPID
410 420 430 440 450
LIASLEKRSN LPGHHEILLA NVFAQAEAFM RGKTPDEVRA ELKAQGMDEA
460 470 480 490 500
RIEELVPHKT FSGNRPTNLI LMDKVNPRNM GSLIAMYEHK TFVQGIIWGI
510 520 530 540
NSFDQWGVEL GKQLAKTILG ELTGETGSQK HDSSTERLIN LYLQTNRK
Length:548
Mass (Da):62,026
Last modified:October 1, 2000 - v1
Checksum:i4BC7F50C0D674BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08745.1.
PIRiA81854.
RefSeqiWP_002245967.1. NC_003116.1.
YP_002342915.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08745; CAM08745; NMA1604.
KEGGinma:NMA1604.
PATRICi20364317. VBINeiMen132687_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08745.1.
PIRiA81854.
RefSeqiWP_002245967.1. NC_003116.1.
YP_002342915.1. NC_003116.1.

3D structure databases

ProteinModelPortaliQ9JTW1.
SMRiQ9JTW1. Positions 3-545.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM08745; CAM08745; NMA1604.
KEGGinma:NMA1604.
PATRICi20364317. VBINeiMen132687_1862.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciNMEN122587:GI3Q-1459-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiG6PI1_NEIMA
AccessioniPrimary (citable) accession number: Q9JTW1
Secondary accession number(s): A1ISI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.