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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145L-tryptophanUniRule annotation1
Binding sitei196ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13ATPUniRule annotation3
Nucleotide bindingi19 – 20ATPUniRule annotation2
Nucleotide bindingi157 – 159ATPUniRule annotation3
Nucleotide bindingi203 – 207ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMEN122587:G1G1G-1853-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:NMA1682
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366531 – 336Tryptophan--tRNA ligaseAdd BLAST336

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9JTQ0
SMRiQ9JTQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 20"HIGH" regionUniRule annotation9
Motifi203 – 207"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059939
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JTQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKRVLTGV TTTGIPHLGN YVGAIRPAVR AAQNPDTESF LFLADYHGII
60 70 80 90 100
KCHEPEMIHQ STQAVAATWL ACGLDPERTT FYRQSDIPEV MELNWILTCI
110 120 130 140 150
TAKGLMNRAH AYKAAVQANA ENGQEDPDFG VEMGLYSYPI LMTADILMFN
160 170 180 190 200
AHEVPVGRDQ IQHVEMARDI AGRFNHRFRE LFTLPEVKID ENVELLVGLD
210 220 230 240 250
GRKMSKSYGN TIPLWENDKK TQKSVNKIIT NMKEPGEPKK PDESPLFEIY
260 270 280 290 300
KAFSTPSETA EFTKMLADGL AWGEAKKLLA AKINAELAEP RERYNELTAD
310 320 330
PSQIEEILQA GAQKARKEAR ELLGKVRDAV GIRPLK
Length:336
Mass (Da):37,622
Last modified:October 1, 2000 - v1
Checksum:i3400C34F42E34536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM08813.1
PIRiE81863
RefSeqiWP_002246991.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM08813; CAM08813; NMA1682
KEGGinma:NMA1682

Similar proteinsi

Entry informationi

Entry nameiSYW_NEIMA
AccessioniPrimary (citable) accession number: Q9JTQ0
Secondary accession number(s): A1ISQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health