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Q9JTQ0

- SYW_NEIMA

UniProt

Q9JTQ0 - SYW_NEIMA

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Protein
Tryptophan--tRNA ligase
Gene
trpS, NMA1682
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei206 – 2061ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1529-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:NMA1682
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136653Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi122587.NMA1682.

Structurei

3D structure databases

ProteinModelPortaliQ9JTQ0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" regionUniRule annotation
Motifi203 – 2075"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059939.
KOiK01867.
OMAiLELYWIL.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JTQ0-1 [UniParc]FASTAAdd to Basket

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MSKKRVLTGV TTTGIPHLGN YVGAIRPAVR AAQNPDTESF LFLADYHGII    50
KCHEPEMIHQ STQAVAATWL ACGLDPERTT FYRQSDIPEV MELNWILTCI 100
TAKGLMNRAH AYKAAVQANA ENGQEDPDFG VEMGLYSYPI LMTADILMFN 150
AHEVPVGRDQ IQHVEMARDI AGRFNHRFRE LFTLPEVKID ENVELLVGLD 200
GRKMSKSYGN TIPLWENDKK TQKSVNKIIT NMKEPGEPKK PDESPLFEIY 250
KAFSTPSETA EFTKMLADGL AWGEAKKLLA AKINAELAEP RERYNELTAD 300
PSQIEEILQA GAQKARKEAR ELLGKVRDAV GIRPLK 336
Length:336
Mass (Da):37,622
Last modified:October 1, 2000 - v1
Checksum:i3400C34F42E34536
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM08813.1.
PIRiE81863.
RefSeqiYP_002342978.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08813; CAM08813; NMA1682.
GeneIDi908071.
KEGGinma:NMA1682.
PATRICi20364560. VBINeiMen132687_1981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM08813.1 .
PIRi E81863.
RefSeqi YP_002342978.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JTQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA1682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM08813 ; CAM08813 ; NMA1682 .
GeneIDi 908071.
KEGGi nma:NMA1682.
PATRICi 20364560. VBINeiMen132687_1981.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059939.
KOi K01867.
OMAi LELYWIL.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci NMEN122587:GI3Q-1529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiSYW_NEIMA
AccessioniPrimary (citable) accession number: Q9JTQ0
Secondary accession number(s): A1ISQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi