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Q9JTQ0 (SYW_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:NMA1682
OrganismNeisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]
Taxonomic identifier122587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136653

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140
Motif203 – 2075"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2061ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JTQ0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3400C34F42E34536

FASTA33637,622
        10         20         30         40         50         60 
MSKKRVLTGV TTTGIPHLGN YVGAIRPAVR AAQNPDTESF LFLADYHGII KCHEPEMIHQ 

        70         80         90        100        110        120 
STQAVAATWL ACGLDPERTT FYRQSDIPEV MELNWILTCI TAKGLMNRAH AYKAAVQANA 

       130        140        150        160        170        180 
ENGQEDPDFG VEMGLYSYPI LMTADILMFN AHEVPVGRDQ IQHVEMARDI AGRFNHRFRE 

       190        200        210        220        230        240 
LFTLPEVKID ENVELLVGLD GRKMSKSYGN TIPLWENDKK TQKSVNKIIT NMKEPGEPKK 

       250        260        270        280        290        300 
PDESPLFEIY KAFSTPSETA EFTKMLADGL AWGEAKKLLA AKINAELAEP RERYNELTAD 

       310        320        330 
PSQIEEILQA GAQKARKEAR ELLGKVRDAV GIRPLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157959 Genomic DNA. Translation: CAM08813.1.
PIRE81863.
RefSeqYP_002342978.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JTQ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122587.NMA1682.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM08813; CAM08813; NMA1682.
GeneID908071.
KEGGnma:NMA1682.
PATRIC20364560. VBINeiMen132687_1981.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMALELYWIL.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycNMEN122587:GI3Q-1529-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_NEIMA
AccessionPrimary (citable) accession number: Q9JTQ0
Secondary accession number(s): A1ISQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries