Q9JTM0 (ACKA1_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase 1
EC=2.7.2.1

Alternative name(s):
Acetokinase 1

Gene names

Name:	ackA1
Ordered Locus Names:	NMA1718

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.
Sequence caution	The sequence CAM08847.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase 1 HAMAP MF_00020		PRO_0000107590

Sequences

	Sequence		Length	Mass (Da)
	Q9JTM0 [UniParc]. Last modified August 22, 2003. Version 2. Checksum: 61AFE1F7BCC77336	FASTA	398	42,468
	10 20 30 40 50 60 MSQKLILVLN CGSSSLKGAV LDNGSGEVLL SCLAEKLNLP DAYITFKVNG EKHKVDLSAH 70 80 90 100 110 120 PDHTGAVEAL MEELKAHGLD SRIGAIGHRV VSGGELYSES ILVDDEVIAG IEKCIPLAPL 130 140 150 160 170 180 HNPAHLLGLR AAQSIFKDLP NVVVFDTSFH QTMPEVAYKY AVPQELYEKY GLRRYGAHGT 190 200 210 220 230 240 SYRFVADETA RFLGKDKKDL RMVIAHLGNG ASITAVANGE SRDTSMGLTP LEGLVMGTRS 250 260 270 280 290 300 GDIDPSVFGF LAENANMTIA QITEMLNKKS GLLGISGLSN DCRTIEEEAA KGHKGAKLAL 310 320 330 340 350 360 DMFIYRLAKY IGSMAVAAGG LDALVFTGGI GENSDIIRER VIGYLGFLGL NIDQEANLKA 370 380 390 RFGNAGVITT ADSKAVAVVI PTNEELMIAH DTARLSGL

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157959 Genomic DNA. Translation: CAM08847.1. Different initiation.
PIR	A81868.
RefSeq	YP_002343012.1. NC_003116.1.
3D structure databases
ProteinModelPortal	Q9JTM0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000000706; EBNEIP00000000706; EBNEIG00000000706.
GeneID	908107.
GenomeReviews	Gene locus NMA1718 in contig AL157959_GR.
KEGG	nma:NMA1718.
PATRIC	20364670. VBINeiMen132687_2036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020921.
HOGENOM	HBG285863.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA1718-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA1_NEIMA

Accession

Primary (citable) accession number: Q9JTM0
Secondary accession number(s): A1IST5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	August 22, 2003
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program