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Q9JTB8

- ANIA_NEIMA

UniProt

Q9JTB8 - ANIA_NEIMA

Protein

Copper-containing nitrite reductase

Gene

aniA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of nitrite to nitric oxide (NO). It could be essential for growth and survival in oxygen-depleted environments By similarity.By similarity

    Catalytic activityi

    Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

    Cofactori

    Binds 1 Cu+ ion.By similarity
    Binds 1 Cu2+ ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi130 – 1301Copper 1; type 1By similarity
    Metal bindingi135 – 1351Copper 2; type 2By similarity
    Binding sitei135 – 1351SubstrateBy similarity
    Metal bindingi170 – 1701Copper 2; type 2By similarity
    Metal bindingi171 – 1711Copper 1; type 1By similarity
    Metal bindingi179 – 1791Copper 1; type 1By similarity
    Metal bindingi184 – 1841Copper 1; type 1By similarity
    Binding sitei276 – 2761SubstrateBy similarity
    Metal bindingi325 – 3251Copper 2; type 2By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. nitrite reductase (NO-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. nitrogen compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciNMEN122587:GI3Q-1731-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper-containing nitrite reductase (EC:1.7.2.1)
    Gene namesi
    Name:aniA
    Ordered Locus Names:NMA1887
    OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
    Taxonomic identifieri122587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000626: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818PROSITE-ProRule annotationAdd
    BLAST
    Chaini19 – 386368Copper-containing nitrite reductasePRO_0000002998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi19 – 191N-palmitoyl cysteineCurated
    Lipidationi19 – 191S-diacylglycerol cysteineCurated

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi122587.NMA1887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JTB8.
    SMRiQ9JTB8. Positions 49-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 19195Plastocyanin-like 1Add
    BLAST
    Domaini241 – 342102Plastocyanin-like 2Add
    BLAST
    Repeati367 – 37151
    Repeati372 – 37652
    Repeati377 – 38153

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni367 – 381153 X 5 AA tandem repeats of A-A-S-A-PAdd
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 2 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000217143.
    KOiK00368.
    OMAiVEKTMKM.
    OrthoDBiEOG61ZTJ4.

    Family and domain databases

    Gene3Di2.60.40.420. 2 hits.
    InterProiIPR011707. Cu-oxidase_3.
    IPR008972. Cupredoxin.
    IPR001287. NO2-reductase_Cu.
    [Graphical view]
    PfamiPF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    PRINTSiPR00695. CUNO2RDTASE.
    SUPFAMiSSF49503. SSF49503. 2 hits.
    TIGRFAMsiTIGR02376. Cu_nitrite_red. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JTB8-1 [UniParc]FASTAAdd to Basket

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    MKRQALAAII ASMFALAACG GEPAAQTPAA SAEAASSAAQ TAAETPAGEL    50
    PVIDAVTTHA PEVPPAIDRD YPAKVRVKME TVEKTMKMDD GVEYRYWTFD 100
    GDVPGRMIRV REGDTVEVEF SNNPSSTVPH NVDFHAATGQ GGGAAATFTA 150
    PGRTSTFSFK ALQPGLYIYH CAVAPVGMHI ANGMYGLILV EPKEGLPKVD 200
    KEFYIVQGDF YTKGKKGAQG LQPFDMDKAI AEQPEYVVFN GHVGAIAGDN 250
    ALKAKAGETV RMYVGNGGPN LVSSFHVIGE IFDKVYVEGG KLINENVQST 300
    IVPAGGSAIV EFKVDIPGSY TLVDHSIFRA FNKGALGQLK VEGAENPEIM 350
    TQKLSDTAYA GNGAAPAASA PAASAPAASA PAKSDY 386
    Length:386
    Mass (Da):40,390
    Last modified:October 1, 2000 - v1
    Checksum:iD0624ED3A3979E88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM09006.1.
    PIRiB81816.
    RefSeqiYP_002343170.1. NC_003116.1.

    Genome annotation databases

    EnsemblBacteriaiCAM09006; CAM09006; NMA1887.
    GeneIDi907183.
    KEGGinma:NMA1887.
    PATRICi20365095. VBINeiMen132687_2242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM09006.1 .
    PIRi B81816.
    RefSeqi YP_002343170.1. NC_003116.1.

    3D structure databases

    ProteinModelPortali Q9JTB8.
    SMRi Q9JTB8. Positions 49-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122587.NMA1887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM09006 ; CAM09006 ; NMA1887 .
    GeneIDi 907183.
    KEGGi nma:NMA1887.
    PATRICi 20365095. VBINeiMen132687_2242.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000217143.
    KOi K00368.
    OMAi VEKTMKM.
    OrthoDBi EOG61ZTJ4.

    Enzyme and pathway databases

    BioCyci NMEN122587:GI3Q-1731-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.420. 2 hits.
    InterProi IPR011707. Cu-oxidase_3.
    IPR008972. Cupredoxin.
    IPR001287. NO2-reductase_Cu.
    [Graphical view ]
    Pfami PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00695. CUNO2RDTASE.
    SUPFAMi SSF49503. SSF49503. 2 hits.
    TIGRFAMsi TIGR02376. Cu_nitrite_red. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z2491.

    Entry informationi

    Entry nameiANIA_NEIMA
    AccessioniPrimary (citable) accession number: Q9JTB8
    Secondary accession number(s): A1IT94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3