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Q9JTB8

- ANIA_NEIMA

UniProt

Q9JTB8 - ANIA_NEIMA

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Protein
Copper-containing nitrite reductase
Gene
aniA, NMA1887
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of nitrite to nitric oxide (NO). It could be essential for growth and survival in oxygen-depleted environments By similarity.

Catalytic activityi

Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

Cofactori

Binds 1 Cu+ ion By similarity.
Binds 1 Cu2+ ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Copper 1; type 1 By similarity
Metal bindingi135 – 1351Copper 2; type 2 By similarity
Binding sitei135 – 1351Substrate By similarity
Metal bindingi170 – 1701Copper 2; type 2 By similarity
Metal bindingi171 – 1711Copper 1; type 1 By similarity
Metal bindingi179 – 1791Copper 1; type 1 By similarity
Metal bindingi184 – 1841Copper 1; type 1 By similarity
Binding sitei276 – 2761Substrate By similarity
Metal bindingi325 – 3251Copper 2; type 2 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. nitrite reductase (NO-forming) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-containing nitrite reductase (EC:1.7.2.1)
Gene namesi
Name:aniA
Ordered Locus Names:NMA1887
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Chaini19 – 386368Copper-containing nitrite reductase
PRO_0000002998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteine Inferred
Lipidationi19 – 191S-diacylglycerol cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi122587.NMA1887.

Structurei

3D structure databases

ProteinModelPortaliQ9JTB8.
SMRiQ9JTB8. Positions 49-350.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 19195Plastocyanin-like 1
Add
BLAST
Domaini241 – 342102Plastocyanin-like 2
Add
BLAST
Repeati367 – 37151
Repeati372 – 37652
Repeati377 – 38153

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 381153 X 5 AA tandem repeats of A-A-S-A-P
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000217143.
KOiK00368.
OMAiVEKTMKM.
OrthoDBiEOG61ZTJ4.

Family and domain databases

Gene3Di2.60.40.420. 2 hits.
InterProiIPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR001287. NO2-reductase_Cu.
[Graphical view]
PfamiPF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PRINTSiPR00695. CUNO2RDTASE.
SUPFAMiSSF49503. SSF49503. 2 hits.
TIGRFAMsiTIGR02376. Cu_nitrite_red. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JTB8-1 [UniParc]FASTAAdd to Basket

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MKRQALAAII ASMFALAACG GEPAAQTPAA SAEAASSAAQ TAAETPAGEL    50
PVIDAVTTHA PEVPPAIDRD YPAKVRVKME TVEKTMKMDD GVEYRYWTFD 100
GDVPGRMIRV REGDTVEVEF SNNPSSTVPH NVDFHAATGQ GGGAAATFTA 150
PGRTSTFSFK ALQPGLYIYH CAVAPVGMHI ANGMYGLILV EPKEGLPKVD 200
KEFYIVQGDF YTKGKKGAQG LQPFDMDKAI AEQPEYVVFN GHVGAIAGDN 250
ALKAKAGETV RMYVGNGGPN LVSSFHVIGE IFDKVYVEGG KLINENVQST 300
IVPAGGSAIV EFKVDIPGSY TLVDHSIFRA FNKGALGQLK VEGAENPEIM 350
TQKLSDTAYA GNGAAPAASA PAASAPAASA PAKSDY 386
Length:386
Mass (Da):40,390
Last modified:October 1, 2000 - v1
Checksum:iD0624ED3A3979E88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09006.1.
PIRiB81816.
RefSeqiYP_002343170.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09006; CAM09006; NMA1887.
GeneIDi907183.
KEGGinma:NMA1887.
PATRICi20365095. VBINeiMen132687_2242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09006.1 .
PIRi B81816.
RefSeqi YP_002343170.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JTB8.
SMRi Q9JTB8. Positions 49-350.
ModBasei Search...

Protein-protein interaction databases

STRINGi 122587.NMA1887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM09006 ; CAM09006 ; NMA1887 .
GeneIDi 907183.
KEGGi nma:NMA1887.
PATRICi 20365095. VBINeiMen132687_2242.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000217143.
KOi K00368.
OMAi VEKTMKM.
OrthoDBi EOG61ZTJ4.

Enzyme and pathway databases

BioCyci NMEN122587:GI3Q-1731-MONOMER.

Family and domain databases

Gene3Di 2.60.40.420. 2 hits.
InterProi IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR001287. NO2-reductase_Cu.
[Graphical view ]
Pfami PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
PRINTSi PR00695. CUNO2RDTASE.
SUPFAMi SSF49503. SSF49503. 2 hits.
TIGRFAMsi TIGR02376. Cu_nitrite_red. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiANIA_NEIMA
AccessioniPrimary (citable) accession number: Q9JTB8
Secondary accession number(s): A1IT94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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