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Protein

Copper-containing nitrite reductase

Gene

aniA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of nitrite to nitric oxide (NO). It could be essential for growth and survival in oxygen-depleted environments (By similarity).By similarity

Catalytic activityi

Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

Cofactori

Protein has several cofactor binding sites:
  • Cu+By similarityNote: Binds 1 Cu+ ion.By similarity
  • Cu2+By similarityNote: Binds 1 Cu2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Copper 1; type 1By similarity1
Metal bindingi135Copper 2; type 2By similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi170Copper 2; type 2By similarity1
Metal bindingi171Copper 1; type 1By similarity1
Metal bindingi179Copper 1; type 1By similarity1
Metal bindingi184Copper 1; type 1By similarity1
Binding sitei276SubstrateBy similarity1
Metal bindingi325Copper 2; type 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-containing nitrite reductase (EC:1.7.2.1)
Gene namesi
Name:aniA
Ordered Locus Names:NMA1887
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18PROSITE-ProRule annotationAdd BLAST18
ChainiPRO_000000299819 – 386Copper-containing nitrite reductaseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JTB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 191Plastocyanin-like 1Add BLAST95
Domaini241 – 342Plastocyanin-like 2Add BLAST102
Repeati367 – 37115
Repeati372 – 37625
Repeati377 – 38135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 3813 X 5 AA tandem repeats of A-A-S-A-PAdd BLAST15

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 2 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000217143.
KOiK00368.
OMAiMPISEGV.

Family and domain databases

Gene3Di2.60.40.420. 2 hits.
InterProiIPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR001287. NO2-reductase_Cu.
[Graphical view]
PfamiPF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PRINTSiPR00695. CUNO2RDTASE.
SUPFAMiSSF49503. SSF49503. 2 hits.
TIGRFAMsiTIGR02376. Cu_nitrite_red. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JTB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQALAAII ASMFALAACG GEPAAQTPAA SAEAASSAAQ TAAETPAGEL
60 70 80 90 100
PVIDAVTTHA PEVPPAIDRD YPAKVRVKME TVEKTMKMDD GVEYRYWTFD
110 120 130 140 150
GDVPGRMIRV REGDTVEVEF SNNPSSTVPH NVDFHAATGQ GGGAAATFTA
160 170 180 190 200
PGRTSTFSFK ALQPGLYIYH CAVAPVGMHI ANGMYGLILV EPKEGLPKVD
210 220 230 240 250
KEFYIVQGDF YTKGKKGAQG LQPFDMDKAI AEQPEYVVFN GHVGAIAGDN
260 270 280 290 300
ALKAKAGETV RMYVGNGGPN LVSSFHVIGE IFDKVYVEGG KLINENVQST
310 320 330 340 350
IVPAGGSAIV EFKVDIPGSY TLVDHSIFRA FNKGALGQLK VEGAENPEIM
360 370 380
TQKLSDTAYA GNGAAPAASA PAASAPAASA PAKSDY
Length:386
Mass (Da):40,390
Last modified:October 1, 2000 - v1
Checksum:iD0624ED3A3979E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM09006.1.
PIRiB81816.
RefSeqiWP_002237256.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09006; CAM09006; NMA1887.
KEGGinma:NMA1887.
PATRICi20365095. VBINeiMen132687_2242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM09006.1.
PIRiB81816.
RefSeqiWP_002237256.1. NC_003116.1.

3D structure databases

ProteinModelPortaliQ9JTB8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM09006; CAM09006; NMA1887.
KEGGinma:NMA1887.
PATRICi20365095. VBINeiMen132687_2242.

Phylogenomic databases

HOGENOMiHOG000217143.
KOiK00368.
OMAiMPISEGV.

Family and domain databases

Gene3Di2.60.40.420. 2 hits.
InterProiIPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR001287. NO2-reductase_Cu.
[Graphical view]
PfamiPF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PRINTSiPR00695. CUNO2RDTASE.
SUPFAMiSSF49503. SSF49503. 2 hits.
TIGRFAMsiTIGR02376. Cu_nitrite_red. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANIA_NEIMA
AccessioniPrimary (citable) accession number: Q9JTB8
Secondary accession number(s): A1IT94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.