Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Copper-containing nitrite reductase

Gene

aniA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of nitrite to nitric oxide (NO). It could be essential for growth and survival in oxygen-depleted environments (By similarity).By similarity

Catalytic activityi

Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

Cofactori

Protein has several cofactor binding sites:
  • Cu+By similarityNote: Binds 1 Cu+ ion.By similarity
  • Cu2+By similarityNote: Binds 1 Cu2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Copper 1; type 1By similarity1
Metal bindingi135Copper 2; type 2By similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi170Copper 2; type 2By similarity1
Metal bindingi171Copper 1; type 1By similarity1
Metal bindingi179Copper 1; type 1By similarity1
Metal bindingi184Copper 1; type 1By similarity1
Binding sitei276SubstrateBy similarity1
Metal bindingi325Copper 2; type 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122587:G1G1G-2104-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-containing nitrite reductase (EC:1.7.2.1)
Gene namesi
Name:aniA
Ordered Locus Names:NMA1887
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18PROSITE-ProRule annotationAdd BLAST18
ChainiPRO_000000299819 – 386Copper-containing nitrite reductaseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9JTB8

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JTB8
SMRiQ9JTB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 191Plastocyanin-like 1Add BLAST95
Domaini241 – 342Plastocyanin-like 2Add BLAST102
Repeati367 – 37115
Repeati372 – 37625
Repeati377 – 38135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 3813 X 5 AA tandem repeats of A-A-S-A-PAdd BLAST15

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000217143
KOiK00368
OMAiQHIARGM

Family and domain databases

Gene3Di2.60.40.420, 2 hits
InterProiView protein in InterPro
IPR011707 Cu-oxidase_3
IPR008972 Cupredoxin
IPR001287 NO2-reductase_Cu
PfamiView protein in Pfam
PF07732 Cu-oxidase_3, 1 hit
PRINTSiPR00695 CUNO2RDTASE
SUPFAMiSSF49503 SSF49503, 2 hits
TIGRFAMsiTIGR02376 Cu_nitrite_red, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JTB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQALAAII ASMFALAACG GEPAAQTPAA SAEAASSAAQ TAAETPAGEL
60 70 80 90 100
PVIDAVTTHA PEVPPAIDRD YPAKVRVKME TVEKTMKMDD GVEYRYWTFD
110 120 130 140 150
GDVPGRMIRV REGDTVEVEF SNNPSSTVPH NVDFHAATGQ GGGAAATFTA
160 170 180 190 200
PGRTSTFSFK ALQPGLYIYH CAVAPVGMHI ANGMYGLILV EPKEGLPKVD
210 220 230 240 250
KEFYIVQGDF YTKGKKGAQG LQPFDMDKAI AEQPEYVVFN GHVGAIAGDN
260 270 280 290 300
ALKAKAGETV RMYVGNGGPN LVSSFHVIGE IFDKVYVEGG KLINENVQST
310 320 330 340 350
IVPAGGSAIV EFKVDIPGSY TLVDHSIFRA FNKGALGQLK VEGAENPEIM
360 370 380
TQKLSDTAYA GNGAAPAASA PAASAPAASA PAKSDY
Length:386
Mass (Da):40,390
Last modified:October 1, 2000 - v1
Checksum:iD0624ED3A3979E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM09006.1
PIRiB81816
RefSeqiWP_002237256.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM09006; CAM09006; NMA1887
KEGGinma:NMA1887

Similar proteinsi

Entry informationi

Entry nameiANIA_NEIMA
AccessioniPrimary (citable) accession number: Q9JTB8
Secondary accession number(s): A1IT94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health