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Q9JT86

- GCSP_NEIMA

UniProt

Q9JT86 - GCSP_NEIMA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, NMA1934
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1777-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NMA1934
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei698 – 6981N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi122587.NMA1934.

Structurei

3D structure databases

ProteinModelPortaliQ9JT86.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiKATEHAI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JT86-1 [UniParc]FASTAAdd to Basket

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MKLSELFNPN EFAARHLSFG DEAALLAAVD EKSMDEFVGN TVPQSIRMPS    50
ELDLPEALTE ADALAKLKGI ASKNMINKSY IGLGYYPTRV PNVILRNVLE 100
NPGWYTAYTP YQAEIAQGRL EALLNFQQVC IDLTGFPVAG ASLLDEATAA 150
AEAMAMAHRV GKVKSERFFV DERVYPQTLD VMKTRAKYFG FELVVGDFAQ 200
ADEGEYFGAL FQYVGKDGDV QDLQDVIGRL KAKGTIVAVA ADIMSLVLLK 250
SPAELGADIA LGNTQRFGVP MGFGGPHAAY FAFKDEFKRS APGRIIGVSK 300
DASGKPALRM ALSTREQHIR REKATSNICT AQALLANLAG MYAVYHGPKG 350
VKRIADRIHA LASAFADALV SDGLNVVHKV FFDTVTVDFG NKEKADQVFA 400
AALESGYNLR RVNDTQVAAA FHETSACEDL VDLYRAFTGK DTFAFADDVK 450
GRLNAELLRQ DDILQHPVFN SYHTEHEMLR YLKKLEDRDL AMNRSMISLG 500
SCTMKLNATA EMLPITWAEF SDIHPYAPEA QTAGYRELLA DMENSLKAIT 550
GFDAISLQPN SGAQGEYTGM LSIRRYQEAQ GEAHRNICLI PKSAHGTNPA 600
TAAMLGLKVV VVDTDEHGNV NIDDLKAKAE QHRDALSAIM ITYPSTHGVY 650
EEGIRDICRI IHENGGQVYM DGANLNAQIG IMQPAEVGAD VLHMNLHKTF 700
CIPHGGGGPG MGPIGLKAHL APFAPGHTLT DTHSASAGQT AVAAAAYGSA 750
SILPITWMYL TMMGKQGMEQ ATRWALLNAN YVAKRLSEDY PILYTGKNGR 800
VAHECIVDLR PLKAESGITE TDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
ESESKAELDR FIATLKSIRR EVQKVIDGEW PKDDNPLVNA PHTAADITGN 900
WAHPYSREEA VFPLPFVREH KFWPFVNRVD DVYGDRNLVC SCPPMENYED 950
Length:950
Mass (Da):104,070
Last modified:October 1, 2000 - v1
Checksum:i23E877C431BC72A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09047.1.
PIRiD81821.
RefSeqiYP_002343208.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09047; CAM09047; NMA1934.
GeneIDi906146.
KEGGinma:NMA1934.
PATRICi20365242. VBINeiMen132687_2310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09047.1 .
PIRi D81821.
RefSeqi YP_002343208.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JT86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA1934.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM09047 ; CAM09047 ; NMA1934 .
GeneIDi 906146.
KEGGi nma:NMA1934.
PATRICi 20365242. VBINeiMen132687_2310.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi KATEHAI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NMEN122587:GI3Q-1777-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiGCSP_NEIMA
AccessioniPrimary (citable) accession number: Q9JT86
Secondary accession number(s): A1ITD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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