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Q9JT70

- DHPS_NEIMA

UniProt

Q9JT70 - DHPS_NEIMA

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Protein

Dihydropteroate synthase

Gene

folP

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251MagnesiumBy similarity
Binding sitei33 – 331SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Binding sitei227 – 2271SubstrateBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Binding sitei264 – 2641SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1793-MONOMER.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Synonyms:dhpS
Ordered Locus Names:NMA1950
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Dihydropteroate synthasePRO_0000168217Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi122587.NMA1950.

Structurei

3D structure databases

ProteinModelPortaliQ9JT70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 274257Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217510.
KOiK00796.
OMAiRIMLDPG.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JT70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGCVWQAGR FEIGLDKPKI MGIVNLTPDS LSDGGAYSQN AQTALAHAER
60 70 80 90 100
LLKEGADILD IGGESTRPGA DYVSPEEEWA RVESVLAEVA GWGVPVSLDT
110 120 130 140 150
RHTVVMEKAL ALGGIDIIND VAALTDEGAL ELLACQADTG ICLMHMQGLP
160 170 180 190 200
KNMQINPKYQ DVVGEVARYL KARAAECIAA GIAPQRITLD PGFCFGKTLQ
210 220 230 240 250
HNITLMRHLP ELMAETGYPL LIGVSRKSMI GELTGETDAA ARGHGSVAAA
260 270 280
LAAVARGAKI VRVHDVKATA DALKAWEALG INL
Length:283
Mass (Da):29,928
Last modified:October 1, 2000 - v1
Checksum:i89A0976A527C9E27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 43VGC → ARH in strain: 1014 and 418.
Natural varianti31 – 311L → F in strain: 1014 and 418.
Natural varianti68 – 681P → L in strain: 418.
Natural varianti75 – 751P → S in strain: 1014.
Natural varianti84 – 841S → P in strain: 1014 and 418.
Natural varianti87 – 871A → E in strain: 418.
Natural varianti87 – 871A → V in strain: 1014.
Natural varianti102 – 1021H → R in strain: 1014 and 418.
Natural varianti105 – 1051V → I in strain: 418.
Natural varianti115 – 1151I → V in strain: 418.
Natural varianti125 – 1251T → N in strain: 418.
Natural varianti130 – 1301L → V in strain: 418.
Natural varianti135 – 1351C → R in strain: 418.
Natural varianti147 – 1471Q → R in strain: 1014.
Natural varianti151 – 1511K → E in strain: 1014.
Natural varianti152 – 1521N → T in strain: 418.
Natural varianti174 – 1741A → S in strain: 418.
Natural varianti188 – 1881T → I in strain: 418.
Natural varianti194 – 1941C → G in strain: 1014.
Natural varianti194 – 1941C → GSG in strain: 418.
Natural varianti198 – 1981T → P in strain: 418.
Natural varianti204 – 2041T → A in strain: 1014 and 418.
Natural varianti218 – 2181Y → F in strain: 1014 and 418.
Natural varianti228 – 2281S → R in strain: 1014.
Natural varianti229 – 2291M → T in strain: 418.
Natural varianti230 – 2301I → V in strain: 1014.
Natural varianti237 – 2382TD → AN in strain: 418.
Natural varianti241 – 2411A → E in strain: 418.
Natural varianti243 – 2431G → V in strain: 1014 and 418.
Natural varianti253 – 2531A → S in strain: 1014 and 418.
Natural varianti255 – 2551A → R in strain: 1014.
Natural varianti259 – 2591K → Q in strain: 1014 and 418.
Natural varianti275 – 2751A → V in strain: 1014 and 418.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68065 Genomic DNA. Translation: CAA48202.1.
X68068 Genomic DNA. Translation: CAA48205.1.
AL157959 Genomic DNA. Translation: CAM09062.1.
PIRiD81823.
S25610.
S65838.
RefSeqiYP_002343223.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09062; CAM09062; NMA1950.
GeneIDi907184.
KEGGinma:NMA1950.
PATRICi20365276. VBINeiMen132687_2326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68065 Genomic DNA. Translation: CAA48202.1 .
X68068 Genomic DNA. Translation: CAA48205.1 .
AL157959 Genomic DNA. Translation: CAM09062.1 .
PIRi D81823.
S25610.
S65838.
RefSeqi YP_002343223.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JT70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA1950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM09062 ; CAM09062 ; NMA1950 .
GeneIDi 907184.
KEGGi nma:NMA1950.
PATRICi 20365276. VBINeiMen132687_2326.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217510.
KOi K00796.
OMAi RIMLDPG.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .
BioCyci NMEN122587:GI3Q-1793-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance."
    Raadstroem P., Fermer C., Kristiansen B.-E., Jenkins A., Skoeld O., Swedberg G.
    J. Bacteriol. 174:6386-6393(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1014 / Serogroup A / Serotype 4/21 and 418 / Serogroup A / Serotype 4/21.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiDHPS_NEIMA
AccessioniPrimary (citable) accession number: Q9JT70
Secondary accession number(s): A1ITE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3