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Q9JT25

- SPEA_NEIMA

UniProt

Q9JT25 - SPEA_NEIMA

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1855-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:NMA2017
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Biosynthetic arginine decarboxylasePRO_0000149964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi122587.NMA2017.

Structurei

3D structure databases

ProteinModelPortaliQ9JT25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 28911Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiDSEDMVE.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JT25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPILTIREVC NINHWGIGYY DVDDSGEIIV RPNPSQHNQI VSLQKLTEAV
60 70 80 90 100
QQKHQARLPV LFCFPQILEH RLRDINRAFQ TAREECGYKG GYCLVYPIKV
110 120 130 140 150
NQHRRVIESL MSSGQPHGLE AGSKAELMAV LAHAGTRQTL IVCNGYKDRE
160 170 180 190 200
YIRFALMGEK LGHQVYLVIE KLSEIQMVLE EAEKLGIKPR LGVRARLASQ
210 220 230 240 250
GSGKWQSSGG EKSKFGLSAS QVLQLVDILK QKNRLDCLQL LHFHLGSQLG
260 270 280 290 300
NIRDVATGVH ESARFYVELH KLGVNIRCFD VGGGLGVDYE GNRTQSDCSV
310 320 330 340 350
NYSLNEYAAT VVWGISQACL EHGLPHPTII TESGRGITAH HAVLVANVIG
360 370 380 390 400
VERYKPRRLD APSPEAPRVL HSMWETWTDI SASREKRSLR SWIHEGQFDL
410 420 430 440 450
ADVHNQYNVG LLSLAQRAWA EQLYLNICHE VGELFNEKHR SHRTIIDELQ
460 470 480 490 500
ERFADKLYVN FSLFQSLPDA WGIDQLFPVC PITGLNEPIA RRAVLLDITC
510 520 530 540 550
DSDGTIDHYI DGDGIAGTMP MPDYPEEEPP LLGFFMVGAY QEILGNMHNL
560 570 580 590 600
FGDTATADVV VGEDGQFTVI DYDEGNTVAD MLEYVYQDPK ELMKRYREQI
610 620 630
EHSDLPASQA MSFLKELEAG LNGYTYLEDE
Length:630
Mass (Da):70,901
Last modified:October 1, 2000 - v1
Checksum:i1E33ACEE7929F314
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09122.1.
PIRiD81831.
RefSeqiYP_002343280.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09122; CAM09122; NMA2017.
GeneIDi907423.
KEGGinma:NMA2017.
PATRICi20365426. VBINeiMen132687_2399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM09122.1 .
PIRi D81831.
RefSeqi YP_002343280.1. NC_003116.1.

3D structure databases

ProteinModelPortali Q9JT25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA2017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM09122 ; CAM09122 ; NMA2017 .
GeneIDi 907423.
KEGGi nma:NMA2017.
PATRICi 20365426. VBINeiMen132687_2399.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi DSEDMVE.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci NMEN122587:GI3Q-1855-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiSPEA_NEIMA
AccessioniPrimary (citable) accession number: Q9JT25
Secondary accession number(s): A1ITK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3