Reviewed, UniProtKB/Swiss-Prot Q9JT07 (ACKA2_NEIMA)

Names and origin

Protein names

Recommended name:
    Acetate kinase 2
    EC=2.7.2.1
Alternative name(s):
    Acetokinase 2

Gene names

Name:	ackA2
Ordered Locus Names:	NMA2050

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Acetate kinase 2 HAMAP MF_00020		PRO_0000107591

Sequences

	Sequence		Length	Mass (Da)
	Q9JT07-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AB1BB615ED5EEC36	FASTA	399	42,783
	10 20 30 40 50 60 MSDQLILVLN CGSSSLKGAV IDRKSGSVVL SCLGERLTTP EAVITFSKDG NKRQVPLSGR 70 80 90 100 110 120 NCHAGAVGML LNELEKHELH DRIQAVGHRI AHGGEKYSES VLIDQAVMDE LNACIPLAPL 130 140 150 160 170 180 HNPANISGIL AAQEHFPGLP NVGVMDTSFH QTMPERAYTY AVPRELRKKY AFRRYGFHGT 190 200 210 220 230 240 SMRYVAPEAA CILGKPLEDI RMIIAHLGNG ASITAIKNGK SVDTSMGFTP IEGLVMGTRC 250 260 270 280 290 300 GDIDPGVYSY LTSHAGLDVA QVDEMLNKKS GLLGISELSN DCRTLEIAAD EGHEGARLAL 310 320 330 340 350 360 EVMTYRLAKY IASMAVGCGG VDALVFTGGI GENSRNIRAK TVSYLDFLGL HIDTKANMEK 370 380 390 RYGNSGIISP TDSSPAVLVV PTNEELMIAC DTAELVGIL

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL157959 Genomic DNA. Translation: CAM09153.1.
PIR	F81775.
RefSeq	YP_002343310.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
Genome annotation databases
GeneID	907391.
GenomeReviews	Gene locus NMA2050 in contig AL157959_GR.
KEGG	nma:NMA2050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9JT07.
OMA	DEGHEGA.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA2050-MON.
BRENDA	2.7.2.1. 292829.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA2_NEIMA

Accession

Primary (citable) accession number: Q9JT07
Secondary accession number(s): A1ITN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)