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Q9JSX4 (NADB_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-aspartate oxidase
Short name=LASPO
EC=1.4.3.16
Alternative name(s):
Quinolinate synthase B
Gene names
Name:nadB
Ordered Locus Names:NMA2092
OrganismNeisseria meningitidis serogroup A [Complete proteome] [HAMAP]
Taxonomic identifier65699 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

L-aspartate:fumarate oxidoreductase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502L-aspartate oxidase
PRO_0000184391

Regions

Nucleotide binding8 – 2215FAD Potential

Sites

Active site2281 By similarity
Active site2491 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JSX4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 039EC390B823BC34

FASTA50254,658
        10         20         30         40         50         60 
MQTDCDVLIA GNGLAALTLA LSLPESFRIV ILCKNRLDDT ASRHAQGGIA AAWSGEDDIE 

        70         80         90        100        110        120 
KHVADTLEAG AGLCNEAAVR TILSQGKPAI EWLLAQGVAF DRSHDGLHLT REGGHTCRRI 

       130        140        150        160        170        180 
AHVADYTGEA VMQSLIVQIR RRPNIRVYER QMALDIQTES GAACGLTVLD RRTQETYNIR 

       190        200        210        220        230        240 
ASHTVLAGGG LGQIYAATTT PPECTGDAIA MAIRAGCAVE NLEFIQFHPT GLARSSENGR 

       250        260        270        280        290        300 
TFLISEAVRG EGGILTNQAG ERFMPHYDRR AELAPRDIVA RAIAAEIAKQ TQDFVSLDIS 

       310        320        330        340        350        360 
HQPAAFVRRH FPSIHRHCLS QCGLDITRQA IPVRPVQHYT CGGIQTDPCG RTSLPQLYAL 

       370        380        390        400        410        420 
GETACTGLHG ANRLASNSLL ECVVTARLCA QAIADGQAFQ AEPFQRPSES LSAEAGIFSD 

       430        440        450        460        470        480 
DLQNTFSRPV LQTFNQRHLG ILRNDTGLRR AIAQLQLWKQ NQAEPHTASE YENRNLLECS 

       490        500 
LAVAQAAYRR RQNIGAHFNS DC

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL157959 Genomic DNA. Translation: CAM09193.1.
PIRE81780.
RefSeqYP_002343347.1. NC_003116.1.

3D structure databases

ProteinModelPortalQ9JSX4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000001167; EBNEIP00000001167; EBNEIG00000001167.
GeneID907351.
GenomeReviewsGene locus NMA2092 in contig AL157959_GR.
KEGGnma:NMA2092.
PATRIC20365682. VBINeiMen132687_2531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000020899.
HOGENOMHBG293998.
OMAHVQDRTG.
ProtClustDBCLSK877531.

Enzyme and pathway databases

BioCycNMEN122587:NMA2092-MONOMER.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00278.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR00551. NadB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADB_NEIMA
AccessionPrimary (citable) accession number: Q9JSX4
Secondary accession number(s): A1ITS5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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