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Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei351 – 3511Proton donorBy similarity
Active sitei382 – 3821By similarity
Active sitei508 – 5081By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1986-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2 (EC:5.3.1.9)
Short name:
GPI 2
Alternative name(s):
Phosphoglucose isomerase 2
Short name:
PGI 2
Phosphohexose isomerase 2
Short name:
PHI 2
Gene namesi
Name:pgi2
Ordered Locus Names:NMA2154
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Glucose-6-phosphate isomerase 2PRO_0000180692Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi122587.NMA2154.

Structurei

3D structure databases

ProteinModelPortaliQ9JSS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiDPACLDE.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JSS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAFTRAWYA LERHYQDTRH VLLRDRFACE PDRFERMHER LDGMLFDYSK
60 70 80 90 100
NRLGEDTLQL LCRLAETADL EGKMRALRTG AKVNNSEGRA ALHTALRLPD
110 120 130 140 150
GAGAVYADGR DVLPEIRREL NRALKFAHSL DDGSYQGTTG KRITDFVHIG
160 170 180 190 200
IGGSDLGPAM CVQALEPFRR HIAVHFAANA DPACLDEVLC RLNPETTVFC
210 220 230 240 250
VASKSFKTPE TLLNAEAVKA WYRGAGFSES ETGCHFCAVS ADTEAAQSFG
260 270 280 290 300
IAAERVFAMY DWVGGRYSVW SPVGLPVMVA VGGARFRELL AGAHAMDSHF
310 320 330 340 350
FHTPPRRNIP VLMALIAVWY NNFQHADGQT AVPYSHNLRL LPAWLNQLDM
360 370 380 390 400
ESLGKSRASD GSPAACKTGG IVFGGEGVNC QHAYFQLLHQ GTRLIPCDFI
410 420 430 440 450
VPMTAQGVED GRSRFTVANA FAQAEALMKG KTLDEARAEL ADLPEAERER
460 470 480 490 500
LAPHKEFPGN RPSNSILLER LTPYNLGMLM AAYEHKTFVQ GVIWDINPFD
510 520 530 540
QWGVEYGKQL AKTIIGELEG GTSVHDASTE GLMAFYRECR LKGGGAA
Length:547
Mass (Da):60,359
Last modified:September 30, 2000 - v1
Checksum:i31FCF5D51F1A9E39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM09250.1.
PIRiG81787.
RefSeqiYP_002343402.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM09250; CAM09250; NMA2154.
KEGGinma:NMA2154.
PATRICi20365826. VBINeiMen132687_2602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM09250.1.
PIRiG81787.
RefSeqiYP_002343402.1. NC_003116.1.

3D structure databases

ProteinModelPortaliQ9JSS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122587.NMA2154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM09250; CAM09250; NMA2154.
KEGGinma:NMA2154.
PATRICi20365826. VBINeiMen132687_2602.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiDPACLDE.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciNMEN122587:GI3Q-1986-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiG6PI2_NEIMA
AccessioniPrimary (citable) accession number: Q9JSS6
Secondary accession number(s): A1ITY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2001
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.