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Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 2 (pgi2)
  3. no protein annotated in this organism
  4. Fructose-1,6-bisphosphate aldolase (NMA0587)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei351Proton donorBy similarity1
Active sitei382By similarity1
Active sitei508By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNMEN122587:G1G1G-2424-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2 (EC:5.3.1.9)
Short name:
GPI 2
Alternative name(s):
Phosphoglucose isomerase 2
Short name:
PGI 2
Phosphohexose isomerase 2
Short name:
PHI 2
Gene namesi
Name:pgi2
Ordered Locus Names:NMA2154
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806921 – 547Glucose-6-phosphate isomerase 2Add BLAST547

Proteomic databases

PRIDEiQ9JSS6

Structurei

3D structure databases

ProteinModelPortaliQ9JSS6
SMRiQ9JSS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

HOGENOMiHOG000261370
KOiK01810
OMAiSFIIPDD

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JSS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAFTRAWYA LERHYQDTRH VLLRDRFACE PDRFERMHER LDGMLFDYSK
60 70 80 90 100
NRLGEDTLQL LCRLAETADL EGKMRALRTG AKVNNSEGRA ALHTALRLPD
110 120 130 140 150
GAGAVYADGR DVLPEIRREL NRALKFAHSL DDGSYQGTTG KRITDFVHIG
160 170 180 190 200
IGGSDLGPAM CVQALEPFRR HIAVHFAANA DPACLDEVLC RLNPETTVFC
210 220 230 240 250
VASKSFKTPE TLLNAEAVKA WYRGAGFSES ETGCHFCAVS ADTEAAQSFG
260 270 280 290 300
IAAERVFAMY DWVGGRYSVW SPVGLPVMVA VGGARFRELL AGAHAMDSHF
310 320 330 340 350
FHTPPRRNIP VLMALIAVWY NNFQHADGQT AVPYSHNLRL LPAWLNQLDM
360 370 380 390 400
ESLGKSRASD GSPAACKTGG IVFGGEGVNC QHAYFQLLHQ GTRLIPCDFI
410 420 430 440 450
VPMTAQGVED GRSRFTVANA FAQAEALMKG KTLDEARAEL ADLPEAERER
460 470 480 490 500
LAPHKEFPGN RPSNSILLER LTPYNLGMLM AAYEHKTFVQ GVIWDINPFD
510 520 530 540
QWGVEYGKQL AKTIIGELEG GTSVHDASTE GLMAFYRECR LKGGGAA
Length:547
Mass (Da):60,359
Last modified:October 1, 2000 - v1
Checksum:i31FCF5D51F1A9E39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA Translation: CAM09250.1
PIRiG81787
RefSeqiWP_002245857.1, NC_003116.1

Genome annotation databases

EnsemblBacteriaiCAM09250; CAM09250; NMA2154
KEGGinma:NMA2154

Similar proteinsi

Entry informationi

Entry nameiG6PI2_NEIMA
AccessioniPrimary (citable) accession number: Q9JSS6
Secondary accession number(s): A1ITY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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