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Reviewed, UniProtKB/Swiss-Prot Q9JS33 (CYSI_NEIMB)

Last modified February 9, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Sulfite reductase [NADPH] hemoprotein beta-component
      Short name=SiR-HP
      Short name=SiRHP
    EC=1.8.1.2
Gene names
Name: cysI1
Synonyms: cysI-1
Ordered Locus Names: NMB1151
AND
Name: cysI2
Synonyms: cysI-2
Ordered Locus Names: NMB1189
OrganismNeisseria meningitidis serogroup B [Complete proteome] [HAMAP]
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

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Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. HAMAP MF_01540

Catalytic activity

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540

Cofactor

Binds 1 siroheme per subunit By similarity. HAMAP MF_01540

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01540

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. HAMAP MF_01540

Subunit structure

Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity. HAMAP MF_01540

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540
PRO_0000199902

Sites

Metal binding4431Iron-sulfur (4Fe-4S) By similarity
Metal binding4491Iron-sulfur (4Fe-4S) By similarity
Metal binding4881Iron-sulfur (4Fe-4S) By similarity
Metal binding4921Iron (siroheme axial ligand) By similarity
Metal binding4921Iron-sulfur (4Fe-4S) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9JS33-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 4D79962B7B7B0339

FASTA58965,966
        10         20         30         40         50         60 
MTVQTKTKGL AWQEKPLSDN ERLKTESNFL RGTILDDLKD PLTGGFKGDN FQLIRFHGMY 

        70         80         90        100        110        120 
EQDDRDIRAE RAEAKLEPLK FMLLRCRLPG GIIKPSQWIE LDKFARENSH YRSIRLTNRQ 

       130        140        150        160        170        180 
TFQFHGVPKA KLQTMHRLLH KLGLDSIATA ADMNRNVLCT SNPIESELHR QAYEYAKKIS 

       190        200        210        220        230        240 
EHLLPRTRGY LDVWVDGKKV QSSDDFLQED EPILGKTYLP RKFKTAVVIP PLNDVDCYGN 

       250        260        270        280        290        300 
DLDFVAVSDG NGQLAGFNVL AGGGLSMEHG NTKTYPNISL ELGFVPPEHA LKAAEAVVTT 

       310        320        330        340        350        360 
QRDFGNRSDR KNARTRYTIQ NMGLDNFRAE VERRMGMPFE PVRPFKFTGR GDRIGWVKGI 

       370        380        390        400        410        420 
DGNWHLTLFI ESGRLVDEGG KQLLTGVLEI AKIHKGDFRI TANQNLIVAN VAEADKAKIE 

       430        440        450        460        470        480 
EFARTYGLIR NDVSKLRENA MSCVSFPTCP LAMAEAERVL PDFIGELDKI MAKHGTSDDY 

       490        500        510        520        530        540 
IVTRITGCPN GCGRAMLAEI GLVGKAVGRY NLHIGGDREG VRIPRLYKEN ITLPEILAEL 

       550        560        570        580 
DDLIGKWAAE RNIGEGFGDF AIRTGIVKPV LNAPVDFWDA SKAVAIARA

« Hide

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF62325.1.
AE002098 Genomic DNA. Translation: AAF62326.1.
RefSeqNP_274179.1.
NP_274215.1.

3D structure databases

SMRQ9JS33. Positions 83-579.
ModBaseSearch...

Genome annotation databases

GeneID903572.
903609.
GenomeReviewsGene locus NMB1151 in contig AE002098_GR.
Gene locus NMB1189 in contig AE002098_GR.
KEGGnme:NMB1151.
nme:NMB1189.
TIGRNMB1151.
NMB1189.

Phylogenomic databases

HOGENOMHBG626671.
OMAIGRYNLH.

Enzyme and pathway databases

BioCycNMEN122586:NMB_1151-MONOMER.
NMEN122586:NMB_1189-MONOMER.
BRENDA1.8.1.2. 293828.

Family and domain databases

HAMAPMF_01540. CysI.
[Tree]
InterProIPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamPF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
TIGRFAMsTIGR02041. CysI. 1 hit.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCYSI_NEIMB
AccessionPrimary (citable) accession number: Q9JS33
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2000
Last modified: February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents