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Q9JRW9

- GSA_CHLPN

UniProt

Q9JRW9 - GSA_CHLPN

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-655-MONOMER.
    CPNE115713:GHEY-143-MONOMER.
    CPNE138677:GH8N-141-MONOMER.
    CPNE182082:GH4N-143-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:CPn_0138, CP_0634, CpB0139
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn0138.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JRW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHGHANAF.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JRW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNCSNQKHT VTFEEACQVF PGGVNSPVRA CRSVGVTPPI VSSAQGDIFL    50
    DTHGREFIDF CGGWGALIHG HSHPKIVKAI QKTALKGTSY GLTSEEEILF 100
    ATMLLSSLKL KEHKIRFVSS GTEATMTAVR LARGITNRSI IIKFIGGYHG 150
    HADTLLGGIS TTEETIDNLT SLIHTPSPHS LLISLPYNNS QILHHVMEAL 200
    GPQVAGIIFE PICANMGIVL PKAEFLDDII ELCKRFGSLS IMDEVVTGFR 250
    VAFQGAKDIF NLSPDITIYG KILGGGLPAA ALVGHRSILD HLMPEGTIFQ 300
    AGTMSGNFLA MATGHAAIQL CQSEGFYDHL SQLEALFYSP IEEEIRSQGF 350
    PVSLVHQGTM FSLFFTESAP TNFDEAKNSD VEKFQTFYSE VFDNGVYLSP 400
    SPLEANFISS AHTEENLTYA QNIIIDSLIK IFDSSAQRFF 440
    Length:440
    Mass (Da):47,956
    Last modified:October 1, 2000 - v1
    Checksum:iBE2C04E0BA3E67CC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti257 – 2571K → Q in strain: CWL029 and TW-183.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18291.1.
    AE002161 Genomic DNA. Translation: AAF38449.1.
    BA000008 Genomic DNA. Translation: BAA98348.1.
    AE009440 Genomic DNA. Translation: AAP98072.1.
    PIRiB86508.
    F81555.
    G72114.
    RefSeqiNP_224346.1. NC_000922.1.
    NP_300197.1. NC_002491.1.
    NP_445176.1. NC_002179.2.
    NP_876415.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18291; AAD18291; CPn_0138.
    AAF38449; AAF38449; CP_0634.
    AAP98072; AAP98072; CpB0139.
    BAA98348; BAA98348; BAA98348.
    GeneIDi1466822.
    894914.
    918926.
    963262.
    KEGGicpa:CP0634.
    cpj:CPj0138.
    cpn:CPn0138.
    cpt:CpB0139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18291.1 .
    AE002161 Genomic DNA. Translation: AAF38449.1 .
    BA000008 Genomic DNA. Translation: BAA98348.1 .
    AE009440 Genomic DNA. Translation: AAP98072.1 .
    PIRi B86508.
    F81555.
    G72114.
    RefSeqi NP_224346.1. NC_000922.1.
    NP_300197.1. NC_002491.1.
    NP_445176.1. NC_002179.2.
    NP_876415.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9JRW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18291 ; AAD18291 ; CPn_0138 .
    AAF38449 ; AAF38449 ; CP_0634 .
    AAP98072 ; AAP98072 ; CpB0139 .
    BAA98348 ; BAA98348 ; BAA98348 .
    GeneIDi 1466822.
    894914.
    918926.
    963262.
    KEGGi cpa:CP0634.
    cpj:CPj0138.
    cpn:CPn0138.
    cpt:CpB0139.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HGHANAF.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci CPNE115711:GI7B-655-MONOMER.
    CPNE115713:GHEY-143-MONOMER.
    CPNE138677:GH8N-141-MONOMER.
    CPNE182082:GH4N-143-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiGSA_CHLPN
    AccessioniPrimary (citable) accession number: Q9JRW9
    Secondary accession number(s): Q9Z945
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3