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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-655-MONOMER.
CPNE115713:GHEY-143-MONOMER.
CPNE138677:GH8N-141-MONOMER.
CPNE182082:GH4N-143-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CPn_0138, CP_0634, CpB0139
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000802 Componenti: Chromosome UP000000583 Componenti: Chromosome UP000000801 Componenti: Chromosome UP000000424 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn0138.

Structurei

3D structure databases

ProteinModelPortaliQ9JRW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTNFDEAK.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JRW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNCSNQKHT VTFEEACQVF PGGVNSPVRA CRSVGVTPPI VSSAQGDIFL
60 70 80 90 100
DTHGREFIDF CGGWGALIHG HSHPKIVKAI QKTALKGTSY GLTSEEEILF
110 120 130 140 150
ATMLLSSLKL KEHKIRFVSS GTEATMTAVR LARGITNRSI IIKFIGGYHG
160 170 180 190 200
HADTLLGGIS TTEETIDNLT SLIHTPSPHS LLISLPYNNS QILHHVMEAL
210 220 230 240 250
GPQVAGIIFE PICANMGIVL PKAEFLDDII ELCKRFGSLS IMDEVVTGFR
260 270 280 290 300
VAFQGAKDIF NLSPDITIYG KILGGGLPAA ALVGHRSILD HLMPEGTIFQ
310 320 330 340 350
AGTMSGNFLA MATGHAAIQL CQSEGFYDHL SQLEALFYSP IEEEIRSQGF
360 370 380 390 400
PVSLVHQGTM FSLFFTESAP TNFDEAKNSD VEKFQTFYSE VFDNGVYLSP
410 420 430 440
SPLEANFISS AHTEENLTYA QNIIIDSLIK IFDSSAQRFF
Length:440
Mass (Da):47,956
Last modified:October 1, 2000 - v1
Checksum:iBE2C04E0BA3E67CC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571K → Q in strain: CWL029 and TW-183.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18291.1.
AE002161 Genomic DNA. Translation: AAF38449.1.
BA000008 Genomic DNA. Translation: BAA98348.1.
AE009440 Genomic DNA. Translation: AAP98072.1.
PIRiB86508.
F81555.
G72114.
RefSeqiNP_224346.1. NC_000922.1.
NP_300197.1. NC_002491.1.
NP_445176.1. NC_002179.2.
NP_876415.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18291; AAD18291; CPn_0138.
AAF38449; AAF38449; CP_0634.
AAP98072; AAP98072; CpB0139.
BAA98348; BAA98348; BAA98348.
GeneIDi894914.
KEGGicpa:CP0634.
cpj:CPj0138.
cpn:CPn0138.
cpt:CpB0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18291.1.
AE002161 Genomic DNA. Translation: AAF38449.1.
BA000008 Genomic DNA. Translation: BAA98348.1.
AE009440 Genomic DNA. Translation: AAP98072.1.
PIRiB86508.
F81555.
G72114.
RefSeqiNP_224346.1. NC_000922.1.
NP_300197.1. NC_002491.1.
NP_445176.1. NC_002179.2.
NP_876415.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9JRW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn0138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD18291; AAD18291; CPn_0138.
AAF38449; AAF38449; CP_0634.
AAP98072; AAP98072; CpB0139.
BAA98348; BAA98348; BAA98348.
GeneIDi894914.
KEGGicpa:CP0634.
cpj:CPj0138.
cpn:CPn0138.
cpt:CpB0139.

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTNFDEAK.
OrthoDBiEOG6QVRHN.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
BioCyciCPNE115711:GI7B-655-MONOMER.
CPNE115713:GHEY-143-MONOMER.
CPNE138677:GH8N-141-MONOMER.
CPNE182082:GH4N-143-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiGSA_CHLPN
AccessioniPrimary (citable) accession number: Q9JRW9
Secondary accession number(s): Q9Z945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.