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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA), Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL), Glutamate-1-semialdehyde 2,1-aminomutase (hemL), Glutamate-1-semialdehyde 2,1-aminomutase (hemL), Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CPn_0138, CP_0634, CpB0139
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203991 – 440Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0139

Structurei

3D structure databases

ProteinModelPortaliQ9JRW9
SMRiQ9JRW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JRW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNCSNQKHT VTFEEACQVF PGGVNSPVRA CRSVGVTPPI VSSAQGDIFL
60 70 80 90 100
DTHGREFIDF CGGWGALIHG HSHPKIVKAI QKTALKGTSY GLTSEEEILF
110 120 130 140 150
ATMLLSSLKL KEHKIRFVSS GTEATMTAVR LARGITNRSI IIKFIGGYHG
160 170 180 190 200
HADTLLGGIS TTEETIDNLT SLIHTPSPHS LLISLPYNNS QILHHVMEAL
210 220 230 240 250
GPQVAGIIFE PICANMGIVL PKAEFLDDII ELCKRFGSLS IMDEVVTGFR
260 270 280 290 300
VAFQGAKDIF NLSPDITIYG KILGGGLPAA ALVGHRSILD HLMPEGTIFQ
310 320 330 340 350
AGTMSGNFLA MATGHAAIQL CQSEGFYDHL SQLEALFYSP IEEEIRSQGF
360 370 380 390 400
PVSLVHQGTM FSLFFTESAP TNFDEAKNSD VEKFQTFYSE VFDNGVYLSP
410 420 430 440
SPLEANFISS AHTEENLTYA QNIIIDSLIK IFDSSAQRFF
Length:440
Mass (Da):47,956
Last modified:October 1, 2000 - v1
Checksum:iBE2C04E0BA3E67CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti257K → Q in strain: CWL029 and TW-183. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18291.1
AE002161 Genomic DNA Translation: AAF38449.1
BA000008 Genomic DNA Translation: BAA98348.1
AE009440 Genomic DNA Translation: AAP98072.1
PIRiB86508
F81555
G72114
RefSeqiNP_224346.1, NC_000922.1

Genome annotation databases

EnsemblBacteriaiAAD18291; AAD18291; CPn_0138
AAF38449; AAF38449; CP_0634
AAP98072; AAP98072; CpB0139
BAA98348; BAA98348; BAA98348
GeneIDi894914
KEGGicpa:CP_0634
cpj:hemL
cpn:CPn0138
cpt:CpB0139
PATRICifig|115713.3.peg.155

Similar proteinsi

Entry informationi

Entry nameiGSA_CHLPN
AccessioniPrimary (citable) accession number: Q9JRW9
Secondary accession number(s): Q9Z945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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