Q9JRW9 (GSA_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	CPn_0138, CP_0634, CpB0139

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000120399
Amino acid modifications
	Modified residue	271	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Natural variant	257	1	K → Q in strain: CWL029 and TW-183.

Sequences

	Sequence		Length	Mass (Da)
	Q9JRW9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: BE2C04E0BA3E67CC	FASTA	440	47,956
	10 20 30 40 50 60 MLNCSNQKHT VTFEEACQVF PGGVNSPVRA CRSVGVTPPI VSSAQGDIFL DTHGREFIDF 70 80 90 100 110 120 CGGWGALIHG HSHPKIVKAI QKTALKGTSY GLTSEEEILF ATMLLSSLKL KEHKIRFVSS 130 140 150 160 170 180 GTEATMTAVR LARGITNRSI IIKFIGGYHG HADTLLGGIS TTEETIDNLT SLIHTPSPHS 190 200 210 220 230 240 LLISLPYNNS QILHHVMEAL GPQVAGIIFE PICANMGIVL PKAEFLDDII ELCKRFGSLS 250 260 270 280 290 300 IMDEVVTGFR VAFQGAKDIF NLSPDITIYG KILGGGLPAA ALVGHRSILD HLMPEGTIFQ 310 320 330 340 350 360 AGTMSGNFLA MATGHAAIQL CQSEGFYDHL SQLEALFYSP IEEEIRSQGF PVSLVHQGTM 370 380 390 400 410 420 FSLFFTESAP TNFDEAKNSD VEKFQTFYSE VFDNGVYLSP SPLEANFISS AHTEENLTYA 430 440 QNIIIDSLIK IFDSSAQRFF

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD18291.1. AE002161 Genomic DNA. Translation: AAF38449.1. BA000008 Genomic DNA. Translation: BAA98348.1. AE009440 Genomic DNA. Translation: AAP98072.1.
PIR	B86508. F81555. G72114.
RefSeq	NP_224346.1. NC_000922.1. NP_300197.1. NC_002491.1. NP_445176.1. NC_002179.2. NP_876415.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9JRW9.
ModBase	Search...
Protein-protein interaction databases
STRING	115713.CPn0138.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD18291; AAD18291; CPn_0138. AAF38449; AAF38449; CP_0634. AAP98072; AAP98072; CpB0139. BAA98348; BAA98348; BAA98348.
GeneID	1466822. 894914. 918926. 963262.
KEGG	cpa:CP0634. cpj:CPj0138. cpn:CPn0138. cpt:CpB0139.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	NELAHEN.
ProtClustDB	PRK00615.
Enzyme and pathway databases
BioCyc	CPNE115711:GI7B-632-MONOMER. CPNE115713:GHEY-141-MONOMER. CPNE138677:GH8N-134-MONOMER. CPNE182082:GH4N-140-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_CHLPN

Accession

Primary (citable) accession number: Q9JRW9
Secondary accession number(s): Q9Z945

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program