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Protein
Submitted name:

D,D-dipeptidase/D,D-carboxypeptidase

Gene

vanXYc

Organism
Enterococcus gallinarum
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Copper; via tele nitrogenCombined sources
Metal bindingi95 – 951Zinc; via tele nitrogenCombined sources
Metal bindingi102 – 1021CopperCombined sources
Metal bindingi102 – 1021ZincCombined sources
Metal bindingi156 – 1561Copper; via pros nitrogenCombined sources
Metal bindingi156 – 1561Zinc; via pros nitrogenCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseImported, Hydrolase, Protease

Keywords - Ligandi

CopperCombined sources, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15477.

Protein family/group databases

MEROPSiM15.003.

Names & Taxonomyi

Protein namesi
Submitted name:
D,D-dipeptidase/D,D-carboxypeptidaseImported
Submitted name:
D,D-dipeptidase/D,D-carboxypeptidase VanXYcImported
Gene namesi
Name:vanXYcImported
OrganismiEnterococcus gallinarumImported
Taxonomic identifieri1353 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi92 – 92Interchain (with C-115)Combined sources
Disulfide bondi115 – 115Interchain (with C-92)Combined sources

Interactioni

Protein-protein interaction databases

STRINGi565653.EGBG_01111.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MURX-ray1.65A/B1-190[»]
4MUSX-ray1.68A/B1-190[»]
4MUTX-ray2.25A/B1-190[»]
4OAKX-ray2.00A/B1-190[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 161130VanYInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108UZE. Bacteria.
COG1876. LUCA.

Family and domain databases

Gene3Di3.30.1380.10. 1 hit.
InterProiIPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR003709. Pept_M15B.
[Graphical view]
PfamiPF02557. VanY. 1 hit.
[Graphical view]
SUPFAMiSSF55166. SSF55166. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JN36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLQLINKN HPLKKNQEPP HLVLAPFSDH DVYLQPEVAK QWERLVRATG
60 70 80 90 100
LEKDIRLVDG YRTEKEQRRL WEYSLKENGL AYTKQFVALP GCSEHQIGLA
110 120 130 140 150
IDVGLKKQED DDLICPHFRD SAAADLFMQQ MMNYGFILRY PEDKQEITGI
160 170 180 190
SYEPWHFRYV GLPHSQVITA QKWTLEEYHD YLAQTVRQFA
Length:190
Mass (Da):22,332
Last modified:October 1, 2000 - v1
Checksum:i83F5695B1FEF4E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162694 Genomic DNA. Translation: AAF61331.1.
DQ022190 Genomic DNA. Translation: AAY67969.1.
RefSeqiWP_003126779.1. NZ_JNLR01000003.1.

Genome annotation databases

EnsemblBacteriaiKIL82782; KIL82782; EH68_00155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162694 Genomic DNA. Translation: AAF61331.1.
DQ022190 Genomic DNA. Translation: AAY67969.1.
RefSeqiWP_003126779.1. NZ_JNLR01000003.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MURX-ray1.65A/B1-190[»]
4MUSX-ray1.68A/B1-190[»]
4MUTX-ray2.25A/B1-190[»]
4OAKX-ray2.00A/B1-190[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi565653.EGBG_01111.

Protein family/group databases

MEROPSiM15.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKIL82782; KIL82782; EH68_00155.

Phylogenomic databases

eggNOGiENOG4108UZE. Bacteria.
COG1876. LUCA.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15477.

Family and domain databases

Gene3Di3.30.1380.10. 1 hit.
InterProiIPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR003709. Pept_M15B.
[Graphical view]
PfamiPF02557. VanY. 1 hit.
[Graphical view]
SUPFAMiSSF55166. SSF55166. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance."
    Dutka-Malen S., Molinas C., Arthur M., Courvalin P.
    Gene 112:53-58(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BM4174Imported.
  2. Castiglia D., Cestelli A., Scaturro M., Di Liegro I.
    Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BM4174Imported.
  3. "Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174."
    Arias C.A., Martin-Martinez M., Blundell T.L., Arthur M., Courvalin P., Reynolds P.E.
    Mol. Microbiol. 31:1653-1664(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BM4174Imported.
  4. "Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174."
    Reynolds P.E., Arias C.A., Courvalin P.
    Mol. Microbiol. 34:341-349(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BM4174Imported.
  5. "vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174."
    Arias C.A., Courvalin P., Reynolds P.E.
    Antimicrob. Agents Chemother. 44:1660-1666(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BM4174Imported.
  6. "Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene."
    Boyd D.A., Miller M.A., Mulvey M.R.
    Antimicrob. Agents Chemother. 50:1067-1070(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N04-0414Imported.
  7. "Structural basis for the evolution of vancomycin resistance D,D-peptidases."
    Meziane-Cherif D., Stogios P.J., Evdokimova E., Savchenko A., Courvalin P.
    Proc. Natl. Acad. Sci. U.S.A. 111:5872-5877(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC, DISULFIDE BONDS.

Entry informationi

Entry nameiQ9JN36_ENTGA
AccessioniPrimary (citable) accession number: Q9JN36
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.