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Protein

Vacuolar protein sorting-associated protein 54

Gene

Vps54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 54
Alternative name(s):
Vps54-like protein
Gene namesi
Name:Vps54
Synonyms:Vps54l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628718. Vps54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965Vacuolar protein sorting-associated protein 54PRO_0000148733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JMK8.
PeptideAtlasiQ9JMK8.
PRIDEiQ9JMK8.

Expressioni

Tissue specificityi

Ubiquitously expressed at low level.1 Publication

Interactioni

Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4998351.
STRINGi10116.ENSRNOP00000010264.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili228 – 24922Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the VPS54 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2115. Eukaryota.
ENOG410XQ3K. LUCA.
HOGENOMiHOG000045110.
HOVERGENiHBG068681.
InParanoidiQ9JMK8.
KOiK17600.
PhylomeDBiQ9JMK8.

Family and domain databases

InterProiIPR012501. Vps54_C.
IPR019515. VPS54_N.
[Graphical view]
PfamiPF07928. Vps54. 1 hit.
PF10475. Vps54_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSHSSSPV PQGSSSDVFF KKEVDPTKHV RPVQSLPDVC PKEPTVTDQH
60 70 80 90 100
RWTVYHSKVN LPAALNDPTL AKRESDFFTK TWGLGFVDTE VIPSLYLPQI
110 120 130 140 150
SKEHFIAYQQ EISQREKIHE RCKNICPPKD TFDRTLLHIH DKSRTDLEQV
160 170 180 190 200
PKIFMKPDFA LDDSLTFNSV LPWSHFNTAG GKGNRDAASS KLLQEKLSHY
210 220 230 240 250
LDIVEVNIAH QISLRSEAFF HAMTSQHELQ DYLKKTSQAV KMLRDKIAQI
260 270 280 290 300
DKVMCEGSLQ ILRLALTRNN CVKVSNKLKL MATVHQTQPT VQVLLSTSEF
310 320 330 340 350
VGALDLIATT QEVLQQELQG VHSFRHLGSQ LCELEKLIDK MMIAEFSTYS
360 370 380 390 400
HSDLNRPLEG ECQVLEEERL VSLVFGLLEQ RKLNFLEIYG EETIITAKNI
410 420 430 440 450
IKECVINKVA QVEEIDTDAV VKLADQMRML NFPQWIDLLK DIFSKFTIFL
460 470 480 490 500
QRVKATLNVI HSVVLSVLDK NQRTRELEEV SQQRSAGKDN SLDTEVAYLT
510 520 530 540 550
HEGLFISDAF SEAEPASAAV DTTSQRNTSP HSEPCSSDSV SEPECTTDSS
560 570 580 590 600
SSKEQTPASA TLGGVDIIVS EDMRLTDLEL GKLASNIQEL LCNASDVCHD
610 620 630 640 650
RAVKFLMSRA KDGFLEKLNS TEFIALSRLM ETYIVDTEQI CGRKSTSLLG
660 670 680 690 700
ALQSQANKFV NRFHEERRTK LSLLLDNERW KQADVPAEFQ DLVDSIADGK
710 720 730 740 750
IALPDKKPAA TEDRKPADVL VVEGHQYAVV GTVLLLIRII LEYCQCVDNI
760 770 780 790 800
PSVTTDMLTR LTDLLKYFNS RSCQLVLGAG ALQVVGLKTI TTKNLALSSR
810 820 830 840 850
CLQLIVHYIP VIRAHFEARL PRKQWSLLRH FDHITKDYHD HIGEISSKLI
860 870 880 890 900
AIMDSLFDKL LSRCEVEAPA PSPCFRNICK QMTKMHEAIF DLLPKEQTQM
910 920 930 940 950
LILRINASYK FHLKKQLSHL NVINDGGPQS GFVTADVAFY TGNLQALKGL
960
KDLDLNMAEI WEQKR
Length:965
Mass (Da):108,842
Last modified:October 1, 2000 - v1
Checksum:iF9DAEFA5A9C8203E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010392 mRNA. Translation: CAB96885.1.
RefSeqiNP_775170.1. NM_173147.1.
UniGeneiRn.107171.

Genome annotation databases

GeneIDi286932.
KEGGirno:286932.
UCSCiRGD:628718. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010392 mRNA. Translation: CAB96885.1.
RefSeqiNP_775170.1. NM_173147.1.
UniGeneiRn.107171.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998351.
STRINGi10116.ENSRNOP00000010264.

Proteomic databases

PaxDbiQ9JMK8.
PeptideAtlasiQ9JMK8.
PRIDEiQ9JMK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286932.
KEGGirno:286932.
UCSCiRGD:628718. rat.

Organism-specific databases

CTDi51542.
RGDi628718. Vps54.

Phylogenomic databases

eggNOGiKOG2115. Eukaryota.
ENOG410XQ3K. LUCA.
HOGENOMiHOG000045110.
HOVERGENiHBG068681.
InParanoidiQ9JMK8.
KOiK17600.
PhylomeDBiQ9JMK8.

Miscellaneous databases

PROiQ9JMK8.

Family and domain databases

InterProiIPR012501. Vps54_C.
IPR019515. VPS54_N.
[Graphical view]
PfamiPF07928. Vps54. 1 hit.
PF10475. Vps54_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification, characterization and cytogenetic mapping of a yeast Vps54 homolog in rat and mouse."
    Walter L., Stark S., Helou K., Fluegge P., Levan G., Guenther E.
    Gene 285:213-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Louvain.

Entry informationi

Entry nameiVPS54_RAT
AccessioniPrimary (citable) accession number: Q9JMK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.