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Q9JMK0 (B4GT5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-1,4-galactosyltransferase 5

Short name=Beta-1,4-GalTase 5
Short name=Beta4Gal-T5
Short name=b4Gal-T5
EC=2.4.1.-
Alternative name(s):
Beta-1,4-GalT II
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
Gene names
Name:B4galt5
Synonyms:Bgt-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids By similarity.

Cofactor

Manganese By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity. Note: Trans cisternae of Golgi stack By similarity.

Tissue specificity

Highest levels in heart, brain, liver and kidney with lower levels in spleen, lung and testis. Ref.1

Developmental stage

In the brain, expression increases after birth. Ref.1

Sequence similarities

Belongs to the glycosyltransferase 7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Beta-1,4-galactosyltransferase 5
PRO_0000080546

Regions

Topological domain1 – 1414Cytoplasmic Potential
Transmembrane15 – 3521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain36 – 388353Lumenal Potential
Region169 – 1735UDP-alpha-D-galactose binding By similarity
Region208 – 2103UDP-alpha-D-galactose binding By similarity
Region235 – 2362UDP-alpha-D-galactose binding By similarity
Region298 – 3014N-acetyl-D-glucosamine binding By similarity
Region329 – 3302UDP-alpha-D-galactose binding By similarity

Sites

Metal binding2361Manganese By similarity
Metal binding3291Manganese; via tele nitrogen By similarity
Binding site2641UDP-alpha-D-galactose By similarity
Binding site2961UDP-alpha-D-galactose By similarity
Binding site3401N-acetyl-D-glucosamine By similarity

Amino acid modifications

Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 158 By similarity
Disulfide bond229 ↔ 248 By similarity

Experimental info

Sequence conflict1921R → A in BAA94791. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JMK0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: FB3D6FBA2F8B3775

FASTA38844,814
        10         20         30         40         50         60 
MRARRGLLRL PRRSLLAALF FFSLSSSLLY FVYVAPGIVN TYLFMVQAQG ILLRDNVRTI 

        70         80         90        100        110        120 
GAQVYEQVVR SAYAKRNSSL NDSDYPLDLN HSEAFPPTTT FLPEDFTYFA NHPCPERLPS 

       130        140        150        160        170        180 
MKGPIDINMS EIAMDDIHEL FSRDPAIKLG GHWKPADCVP RWKVAILIPF RNRHEHLPVL 

       190        200        210        220        230        240 
LRHLLPMLQR QRLQFAFYVI EQVGTQPFNR AMLFNVGFQE AMKDLDWDCL IFHDVDHIPE 

       250        260        270        280        290        300 
SDRNYYGCGQ MPRHFATKLD KYMYLLPYTE FFGGVSGLTV EQFRKINGFP NAFWGWGGED 

       310        320        330        340        350        360 
DDLWNRVQNA GYSVSRPEGD TGKYKSIPHH HRGEVQFLGR YALLRKSKER QGLDGLNNLN 

       370        380 
YSANVTYDAL YKNITVNLTP ELAQVTEY 

« Hide

References

« Hide 'large scale' references
[1]"Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development."
Nakamura N., Yamakawa N., Sato T., Tojo H., Tachi C., Furukawa K.
J. Neurochem. 76:29-38(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: BALB/c.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB004786 mRNA. Translation: BAA94791.1.
AL591854, AL591762 Genomic DNA. Translation: CAM13428.1.
CH466551 Genomic DNA. Translation: EDL06506.1.
RefSeqNP_062809.2. NM_019835.2.
UniGeneMm.200886.
Mm.489868.

3D structure databases

ProteinModelPortalQ9JMK0.
SMRQ9JMK0. Positions 114-380.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT7. Glycosyltransferase Family 7.

PTM databases

PhosphoSiteQ9JMK0.

Proteomic databases

PRIDEQ9JMK0.

Protocols and materials databases

DNASU56336.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000109221; ENSMUSP00000104844; ENSMUSG00000017929.
GeneID56336.
KEGGmmu:56336.
UCSCuc008nzm.1. mouse.

Organism-specific databases

CTD9334.
MGIMGI:1927169. B4galt5.

Phylogenomic databases

eggNOGNOG327897.
GeneTreeENSGT00750000117412.
HOGENOMHOG000231027.
HOVERGENHBG058334.
InParanoidA2A5T7.
KOK09905.
OMALPYTEFF.
OrthoDBEOG7060R0.
TreeFamTF312834.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

ArrayExpressQ9JMK0.
BgeeQ9JMK0.
GenevestigatorQ9JMK0.

Family and domain databases

InterProIPR003859. Galactosyl_T.
IPR027791. Galactosyl_T_C.
IPR027995. Galactosyl_T_N.
[Graphical view]
PANTHERPTHR19300. PTHR19300. 1 hit.
PfamPF02709. Glyco_transf_7C. 1 hit.
PF13733. Glyco_transf_7N. 1 hit.
[Graphical view]
PRINTSPR02050. B14GALTRFASE.
ProtoNetSearch...

Other

ChiTaRSB4GALT5. mouse.
NextBio312326.
PROQ9JMK0.
SOURCESearch...

Entry information

Entry nameB4GT5_MOUSE
AccessionPrimary (citable) accession number: Q9JMK0
Secondary accession number(s): A2A5T7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot