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Protein

F-box/WD repeat-containing protein 4

Gene

Fbxw4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • limb development Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processUbl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 4
Alternative name(s):
F-box and WD-40 domain-containing protein 4
Protein hagoromo
Gene namesi
Name:Fbxw4
Synonyms:Fbw4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1354698 Fbxw4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509911 – 410F-box/WD repeat-containing protein 4Add BLAST410

Proteomic databases

PaxDbiQ9JMJ2
PRIDEiQ9JMJ2

PTM databases

PhosphoSitePlusiQ9JMJ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000040913
CleanExiMM_FBXW4
ExpressionAtlasiQ9JMJ2 baseline and differential
GenevisibleiQ9JMJ2 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (Probable). Interacts with POUF51 (PubMed:29153991).Curated1 Publication

Protein-protein interaction databases

BioGridi205975, 4 interactors
STRINGi10090.ENSMUSP00000036505

Structurei

3D structure databases

ProteinModelPortaliQ9JMJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati159 – 196WD 1Add BLAST38
Repeati198 – 235WD 2Add BLAST38
Repeati289 – 327WD 3Add BLAST39
Repeati333 – 372WD 4Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410II9E Eukaryota
ENOG4111J40 LUCA
GeneTreeiENSGT00390000005029
HOGENOMiHOG000112554
HOVERGENiHBG051594
InParanoidiQ9JMJ2
KOiK10262
OMAiHDSALYC
OrthoDBiEOG091G092K
PhylomeDBiQ9JMJ2
TreeFamiTF325020

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JMJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDAAEDAA AAAVEPATRP AAGPALWRLP EELLLLICSY LDTRALGRLA
60 70 80 90 100
QVCRWLRRFT SCDLLWRPIA RASLNTGFTR LGTDLMAGIP VKERVKLSQN
110 120 130 140 150
WRLGRCRDRI LLKWRYSQMP WMQLQDASLY LSQANFILAY QFRPDGASLN
160 170 180 190 200
RRPFRVFSGH DEDVCHFVLA NSHIVSAGGD GKIGVHKIHS TFTVKYSAHE
210 220 230 240 250
QEVNCVDCKG GIIVSGSRDR TAKVWPLASG RLGQCLHTIQ TEDRVWSIAI
260 270 280 290 300
SPLLSSFVTG TACCGHFSPL RIWDLNSGQL ITHLGSDFPP GAGVLDVMYE
310 320 330 340 350
SPSTLLSCGY DTYVRYWDLR TSTRKCVMEW EEPHDSTFYC LQTDGNHLLA
360 370 380 390 400
TGSSYYGLVR LWDRRQRACL HAFSLTSTPL SSPVYCLRFT TRHLYAALSY
410
NLHVLDFQNP
Length:410
Mass (Da):46,142
Last modified:October 1, 2000 - v1
Checksum:i01BC047352B184C6
GO

Sequence cautioni

The sequence AAF22827 differs from that shown. Reason: Frameshift at position 224.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → F in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti47 – 50GRLA → APG in AAF22827 (PubMed:10531037).Curated4
Sequence conflicti58R → A in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti185V → I in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti218R → M in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti222 – 230AKVWPLASG → SKVPFAASV (PubMed:10531037).Curated9
Sequence conflicti241T → I (PubMed:10531037).Curated1
Sequence conflicti249A → V (PubMed:10531037).Curated1
Sequence conflicti273W → C (PubMed:10531037).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022163 mRNA Translation: BAA94666.1
AF176519 mRNA Translation: AAF22827.1 Frameshift.
BC027031 mRNA Translation: AAH27031.1
CCDSiCCDS29863.1
RefSeqiNP_038935.1, NM_013907.2
UniGeneiMm.254739

Genome annotation databases

EnsembliENSMUST00000046869; ENSMUSP00000036505; ENSMUSG00000040913
GeneIDi30838
KEGGimmu:30838
UCSCiuc008hrf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFBXW4_MOUSE
AccessioniPrimary (citable) accession number: Q9JMJ2
Secondary accession number(s): Q9QXW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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