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Protein

F-box/WD repeat-containing protein 4

Gene

Fbxw4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

GO - Biological processi

  • cartilage development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • limb development Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 4
Alternative name(s):
F-box and WD-40 domain-containing protein 4
Protein hagoromo
Gene namesi
Name:Fbxw4
Synonyms:Fbw4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1354698. Fbxw4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509911 – 410F-box/WD repeat-containing protein 4Add BLAST410

Proteomic databases

PaxDbiQ9JMJ2.
PRIDEiQ9JMJ2.

PTM databases

PhosphoSitePlusiQ9JMJ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040913.
CleanExiMM_FBXW4.
ExpressionAtlasiQ9JMJ2. baseline and differential.
GenevisibleiQ9JMJ2. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi205975. 4 interactors.
STRINGi10090.ENSMUSP00000036505.

Structurei

3D structure databases

ProteinModelPortaliQ9JMJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati159 – 196WD 1Add BLAST38
Repeati198 – 235WD 2Add BLAST38
Repeati289 – 327WD 3Add BLAST39
Repeati333 – 372WD 4Add BLAST40

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410II9E. Eukaryota.
ENOG4111J40. LUCA.
GeneTreeiENSGT00390000005029.
HOGENOMiHOG000112554.
HOVERGENiHBG051594.
InParanoidiQ9JMJ2.
KOiK10262.
OMAiGTACCEN.
OrthoDBiEOG091G092K.
PhylomeDBiQ9JMJ2.
TreeFamiTF325020.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDAAEDAA AAAVEPATRP AAGPALWRLP EELLLLICSY LDTRALGRLA
60 70 80 90 100
QVCRWLRRFT SCDLLWRPIA RASLNTGFTR LGTDLMAGIP VKERVKLSQN
110 120 130 140 150
WRLGRCRDRI LLKWRYSQMP WMQLQDASLY LSQANFILAY QFRPDGASLN
160 170 180 190 200
RRPFRVFSGH DEDVCHFVLA NSHIVSAGGD GKIGVHKIHS TFTVKYSAHE
210 220 230 240 250
QEVNCVDCKG GIIVSGSRDR TAKVWPLASG RLGQCLHTIQ TEDRVWSIAI
260 270 280 290 300
SPLLSSFVTG TACCGHFSPL RIWDLNSGQL ITHLGSDFPP GAGVLDVMYE
310 320 330 340 350
SPSTLLSCGY DTYVRYWDLR TSTRKCVMEW EEPHDSTFYC LQTDGNHLLA
360 370 380 390 400
TGSSYYGLVR LWDRRQRACL HAFSLTSTPL SSPVYCLRFT TRHLYAALSY
410
NLHVLDFQNP
Length:410
Mass (Da):46,142
Last modified:October 1, 2000 - v1
Checksum:i01BC047352B184C6
GO

Sequence cautioni

The sequence AAF22827 differs from that shown. Reason: Frameshift at position 224.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → F in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti47 – 50GRLA → APG in AAF22827 (PubMed:10531037).Curated4
Sequence conflicti58R → A in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti185V → I in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti218R → M in AAF22827 (PubMed:10531037).Curated1
Sequence conflicti222 – 230AKVWPLASG → SKVPFAASV (PubMed:10531037).Curated9
Sequence conflicti241T → I (PubMed:10531037).Curated1
Sequence conflicti249A → V (PubMed:10531037).Curated1
Sequence conflicti273W → C (PubMed:10531037).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022163 mRNA. Translation: BAA94666.1.
AF176519 mRNA. Translation: AAF22827.1. Frameshift.
BC027031 mRNA. Translation: AAH27031.1.
CCDSiCCDS29863.1.
RefSeqiNP_038935.1. NM_013907.2.
UniGeneiMm.254739.

Genome annotation databases

EnsembliENSMUST00000046869; ENSMUSP00000036505; ENSMUSG00000040913.
GeneIDi30838.
KEGGimmu:30838.
UCSCiuc008hrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022163 mRNA. Translation: BAA94666.1.
AF176519 mRNA. Translation: AAF22827.1. Frameshift.
BC027031 mRNA. Translation: AAH27031.1.
CCDSiCCDS29863.1.
RefSeqiNP_038935.1. NM_013907.2.
UniGeneiMm.254739.

3D structure databases

ProteinModelPortaliQ9JMJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205975. 4 interactors.
STRINGi10090.ENSMUSP00000036505.

PTM databases

PhosphoSitePlusiQ9JMJ2.

Proteomic databases

PaxDbiQ9JMJ2.
PRIDEiQ9JMJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046869; ENSMUSP00000036505; ENSMUSG00000040913.
GeneIDi30838.
KEGGimmu:30838.
UCSCiuc008hrf.1. mouse.

Organism-specific databases

CTDi6468.
MGIiMGI:1354698. Fbxw4.

Phylogenomic databases

eggNOGiENOG410II9E. Eukaryota.
ENOG4111J40. LUCA.
GeneTreeiENSGT00390000005029.
HOGENOMiHOG000112554.
HOVERGENiHBG051594.
InParanoidiQ9JMJ2.
KOiK10262.
OMAiGTACCEN.
OrthoDBiEOG091G092K.
PhylomeDBiQ9JMJ2.
TreeFamiTF325020.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFbxw4. mouse.
PROiQ9JMJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040913.
CleanExiMM_FBXW4.
ExpressionAtlasiQ9JMJ2. baseline and differential.
GenevisibleiQ9JMJ2. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXW4_MOUSE
AccessioniPrimary (citable) accession number: Q9JMJ2
Secondary accession number(s): Q9QXW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.