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Protein

F-box/WD repeat-containing protein 4

Gene

Fbxw4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

GO - Biological processi

  • cartilage development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • limb development Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 4
Alternative name(s):
F-box and WD-40 domain-containing protein 4
Protein hagoromo
Gene namesi
Name:Fbxw4
Synonyms:Fbw4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1354698. Fbxw4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410F-box/WD repeat-containing protein 4PRO_0000050991Add
BLAST

Proteomic databases

MaxQBiQ9JMJ2.
PaxDbiQ9JMJ2.
PRIDEiQ9JMJ2.

PTM databases

PhosphoSiteiQ9JMJ2.

Expressioni

Gene expression databases

BgeeiQ9JMJ2.
CleanExiMM_FBXW4.
ExpressionAtlasiQ9JMJ2. baseline and differential.
GenevisibleiQ9JMJ2. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi205975. 4 interactions.
STRINGi10090.ENSMUSP00000036505.

Structurei

3D structure databases

ProteinModelPortaliQ9JMJ2.
SMRiQ9JMJ2. Positions 29-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 6947F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati159 – 19638WD 1Add
BLAST
Repeati198 – 23538WD 2Add
BLAST
Repeati289 – 32739WD 3Add
BLAST
Repeati333 – 37240WD 4Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410II9E. Eukaryota.
ENOG4111J40. LUCA.
GeneTreeiENSGT00390000005029.
HOGENOMiHOG000112554.
HOVERGENiHBG051594.
InParanoidiQ9JMJ2.
KOiK10262.
OMAiGTACCEN.
OrthoDBiEOG76HQ19.
PhylomeDBiQ9JMJ2.
TreeFamiTF325020.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JMJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDAAEDAA AAAVEPATRP AAGPALWRLP EELLLLICSY LDTRALGRLA
60 70 80 90 100
QVCRWLRRFT SCDLLWRPIA RASLNTGFTR LGTDLMAGIP VKERVKLSQN
110 120 130 140 150
WRLGRCRDRI LLKWRYSQMP WMQLQDASLY LSQANFILAY QFRPDGASLN
160 170 180 190 200
RRPFRVFSGH DEDVCHFVLA NSHIVSAGGD GKIGVHKIHS TFTVKYSAHE
210 220 230 240 250
QEVNCVDCKG GIIVSGSRDR TAKVWPLASG RLGQCLHTIQ TEDRVWSIAI
260 270 280 290 300
SPLLSSFVTG TACCGHFSPL RIWDLNSGQL ITHLGSDFPP GAGVLDVMYE
310 320 330 340 350
SPSTLLSCGY DTYVRYWDLR TSTRKCVMEW EEPHDSTFYC LQTDGNHLLA
360 370 380 390 400
TGSSYYGLVR LWDRRQRACL HAFSLTSTPL SSPVYCLRFT TRHLYAALSY
410
NLHVLDFQNP
Length:410
Mass (Da):46,142
Last modified:October 1, 2000 - v1
Checksum:i01BC047352B184C6
GO

Sequence cautioni

The sequence AAF22827.1 differs from that shown. Reason: Frameshift at position 224. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391S → F in AAF22827 (PubMed:10531037).Curated
Sequence conflicti47 – 504GRLA → APG in AAF22827 (PubMed:10531037).Curated
Sequence conflicti58 – 581R → A in AAF22827 (PubMed:10531037).Curated
Sequence conflicti185 – 1851V → I in AAF22827 (PubMed:10531037).Curated
Sequence conflicti218 – 2181R → M in AAF22827 (PubMed:10531037).Curated
Sequence conflicti222 – 2309AKVWPLASG → SKVPFAASV (PubMed:10531037).Curated
Sequence conflicti241 – 2411T → I (PubMed:10531037).Curated
Sequence conflicti249 – 2491A → V (PubMed:10531037).Curated
Sequence conflicti273 – 2731W → C (PubMed:10531037).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022163 mRNA. Translation: BAA94666.1.
AF176519 mRNA. Translation: AAF22827.1. Frameshift.
BC027031 mRNA. Translation: AAH27031.1.
CCDSiCCDS29863.1.
RefSeqiNP_038935.1. NM_013907.2.
UniGeneiMm.254739.

Genome annotation databases

EnsembliENSMUST00000046869; ENSMUSP00000036505; ENSMUSG00000040913.
GeneIDi30838.
KEGGimmu:30838.
UCSCiuc008hrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022163 mRNA. Translation: BAA94666.1.
AF176519 mRNA. Translation: AAF22827.1. Frameshift.
BC027031 mRNA. Translation: AAH27031.1.
CCDSiCCDS29863.1.
RefSeqiNP_038935.1. NM_013907.2.
UniGeneiMm.254739.

3D structure databases

ProteinModelPortaliQ9JMJ2.
SMRiQ9JMJ2. Positions 29-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205975. 4 interactions.
STRINGi10090.ENSMUSP00000036505.

PTM databases

PhosphoSiteiQ9JMJ2.

Proteomic databases

MaxQBiQ9JMJ2.
PaxDbiQ9JMJ2.
PRIDEiQ9JMJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046869; ENSMUSP00000036505; ENSMUSG00000040913.
GeneIDi30838.
KEGGimmu:30838.
UCSCiuc008hrf.1. mouse.

Organism-specific databases

CTDi6468.
MGIiMGI:1354698. Fbxw4.

Phylogenomic databases

eggNOGiENOG410II9E. Eukaryota.
ENOG4111J40. LUCA.
GeneTreeiENSGT00390000005029.
HOGENOMiHOG000112554.
HOVERGENiHBG051594.
InParanoidiQ9JMJ2.
KOiK10262.
OMAiGTACCEN.
OrthoDBiEOG76HQ19.
PhylomeDBiQ9JMJ2.
TreeFamiTF325020.

Miscellaneous databases

ChiTaRSiFbxw4. mouse.
PROiQ9JMJ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JMJ2.
CleanExiMM_FBXW4.
ExpressionAtlasiQ9JMJ2. baseline and differential.
GenevisibleiQ9JMJ2. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies."
    Kawakami K., Amsterdam A., Shimoda N., Becker T., Mugg J., Shima A., Hopkins N.
    Curr. Biol. 10:463-466(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.

Entry informationi

Entry nameiFBXW4_MOUSE
AccessioniPrimary (citable) accession number: Q9JMJ2
Secondary accession number(s): Q9QXW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.