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Q9JMI9

- TRPC3_RAT

UniProt

Q9JMI9 - TRPC3_RAT

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Protein

Short transient receptor potential channel 3

Gene

Trpc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion.By similarity

GO - Molecular functioni

  1. calcium activated cation channel activity Source: RGD
  2. calcium channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Trp-related protein 3
Gene namesi
Name:Trpc3
Synonyms:Trrp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61973. Trpc3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Short transient receptor potential channel 3PRO_0000215312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JMI9.

PTM databases

PhosphoSiteiQ9JMI9.

Expressioni

Gene expression databases

GenevestigatoriQ9JMI9.

Interactioni

Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-59688N.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 369369CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini391 – 41828ExtracellularSequence AnalysisAdd
BLAST
Topological domaini440 – 45112CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini473 – 52351ExtracellularSequence AnalysisAdd
BLAST
Topological domaini545 – 56723CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini589 – 63749ExtracellularSequence AnalysisAdd
BLAST
Topological domaini659 – 836178CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence AnalysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence AnalysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 5530ANK 1Add
BLAST
Repeati61 – 9030ANK 2Add
BLAST
Repeati92 – 11827ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9JMI9.
PhylomeDBiQ9JMI9.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF8. PTHR10117:SF8. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JMI9) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
RTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL GHPGFAASRR LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCHK YEVVHLLLLK GARIERPHDY FCRCADCAEK QRLDAFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SVEPLERHGH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVIDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYIVQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SHVQESDLSE
510 520 530 540 550
VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR ITNFSKCRRR RLQKDLELGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SALRCE
Length:836
Mass (Da):95,682
Last modified:May 26, 2009 - v3
Checksum:iE405FBFC9285613F
GO
Isoform 2 (identifier: Q9JMI9-2)

Also known as: Trp3SV

Sequence is not available

Note: No experimental confirmation available.

Length:
Mass (Da):

Sequence cautioni

The sequence BAA93434.1 differs from that shown. Reason: Chimeric cDNA.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351A → S in BAA93434. (PubMed:10984475)Curated
Sequence conflicti361 – 3611S → T in BAA93434. (PubMed:10984475)Curated
Sequence conflicti394 – 3941D → H in BAA93434. (PubMed:10984475)Curated
Sequence conflicti486 – 4861Q → H in BAA93434. (PubMed:10984475)Curated
Sequence conflicti506 – 5061E → K in BAA93434. (PubMed:10984475)Curated
Sequence conflicti563 – 5631K → E in BAA93434. (PubMed:10984475)Curated
Sequence conflicti567 – 5671K → Q in BAA93434. (PubMed:10984475)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03013307 Genomic DNA. No translation available.
AABR03015957 Genomic DNA. No translation available.
AB022331 mRNA. Translation: BAA93434.1. Sequence problems.
UniGeneiRn.45385.

Genome annotation databases

UCSCiRGD:61973. rat. [Q9JMI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03013307 Genomic DNA. No translation available.
AABR03015957 Genomic DNA. No translation available.
AB022331 mRNA. Translation: BAA93434.1 . Sequence problems.
UniGenei Rn.45385.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59688N.

PTM databases

PhosphoSitei Q9JMI9.

Proteomic databases

PRIDEi Q9JMI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:61973. rat. [Q9JMI9-1 ]

Organism-specific databases

RGDi 61973. Trpc3.

Phylogenomic databases

eggNOGi NOG254238.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q9JMI9.
PhylomeDBi Q9JMI9.

Miscellaneous databases

PROi Q9JMI9.

Gene expression databases

Genevestigatori Q9JMI9.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF8. PTHR10117:SF8. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "A calcium-activated cation current by an alternatively spliced form of Trp3 in the heart."
    Ohki G., Miyoshi T., Murata M., Ishibashi K., Imai M., Suzuki M.
    J. Biol. Chem. 275:39055-39060(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-836.
    Tissue: Heart.

Entry informationi

Entry nameiTRPC3_RAT
AccessioniPrimary (citable) accession number: Q9JMI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3