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Protein

Unconventional myosin-XVIIIa

Gene

Myo18a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi498 – 505ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVIIIa
Alternative name(s):
Molecule associated with JAK3 N-terminus
Short name:
MAJN
Myosin containing a PDZ domain
Surfactant protein receptor SP-R2101 Publication
Short name:
SP-R2101 Publication
Gene namesi
Name:Myo18a
Synonyms:Myspdz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2667185. Myo18a.

Subcellular locationi

Isoform 2 :
  • Cytoplasm

  • Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm.

GO - Cellular componenti

  • actomyosin Source: MGI
  • brush border Source: UniProtKB
  • cytoskeleton Source: MGI
  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: GOC
  • membrane Source: MGI
  • myosin complex Source: UniProtKB-KW
  • nucleoplasm Source: MGI
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi503 – 504GK → SA: Loss of function. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234771 – 2050Unconventional myosin-XVIIIaAdd BLAST2050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei74PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei98PhosphoserineBy similarity1
Modified residuei99PhosphothreonineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei157PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei234PhosphoserineBy similarity1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1063PhosphoserineBy similarity1
Modified residuei1064PhosphoserineBy similarity1
Modified residuei1066PhosphoserineBy similarity1
Modified residuei1636PhosphoserineBy similarity1
Modified residuei1938PhosphoserineBy similarity1
Modified residuei1966PhosphoserineCombined sources1
Modified residuei1970PhosphoserineBy similarity1
Modified residuei1994PhosphoserineCombined sources1
Modified residuei1998PhosphoserineBy similarity1
Modified residuei2002PhosphoserineBy similarity1
Modified residuei2003PhosphoserineBy similarity1
Modified residuei2016PhosphoserineCombined sources1
Modified residuei2032PhosphoserineCombined sources1
Modified residuei2037PhosphoserineCombined sources1
Modified residuei2039PhosphoserineCombined sources1
Modified residuei2041PhosphothreonineCombined sources1
Isoform 6 (identifier: Q9JMH9-6)
Modified residuei340PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine upon CSF1R activation. Isoform 6 is phosphorylated on Ser-340.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JMH9.
PaxDbiQ5QD54.
Q9JMH9.
PeptideAtlasiQ9JMH9.
PRIDEiQ9JMH9.

PTM databases

iPTMnetiQ9JMH9.
PhosphoSitePlusiQ9JMH9.

Expressioni

Tissue specificityi

Isoform 1; Expressed ubiquitously. Isoform 2: Specifically expressed in most hematopoietic cells. Isoform 3: Predominantly expressed in alveolar macrophages (PubMed:25965346).1 Publication

Gene expression databases

BgeeiENSMUSG00000000631.
CleanExiMM_MYO18A.
ExpressionAtlasiQ9JMH9. baseline and differential.
GenevisibleiQ9JMH9. MM.

Interactioni

Subunit structurei

Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A (By similarity). Binds F-actin; regulated by ADP and GOLPH3 (PubMed:15582604). Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton (By similarity). Interacts with JAK3 (PubMed:10733938). Interacts with MSR1 and CD14 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237427. 3 interactors.
IntActiQ9JMH9. 6 interactors.
MINTiMINT-1634736.
STRINGi10090.ENSMUSP00000090563.

Structurei

3D structure databases

ProteinModelPortaliQ9JMH9.
SMRiQ9JMH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 311PDZPROSITE-ProRule annotationAdd BLAST92
Domaini405 – 1181Myosin motorAdd BLAST777
Domaini1184 – 1213IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 398Mediates nucleotide-independent binding to F-actin and interaction with GOLPH3By similarityAdd BLAST398

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1242 – 1967Sequence analysisAdd BLAST726

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 118Interaction with actinBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 25Lys-richAdd BLAST20

Domaini

The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (By similarity).By similarity

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133702.
HOVERGENiHBG052543.
InParanoidiQ9JMH9.
KOiK10362.
PhylomeDBiQ9JMH9.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9JMH9-3) [UniParc]FASTAAdd to basket
Also known as: SP-R210L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR
60 70 80 90 100
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA
110 120 130 140 150
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA
160 170 180 190 200
SETSTPSEHS AAPSPQVEVR TLEGQLMQHP GLGIPRPGPR SRVPELVTKR
210 220 230 240 250
FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM LDRAPEGQAY
260 270 280 290 300
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG
310 320 330 340 350
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADAKTEEQI AAEEAWYETE
360 370 380 390 400
KVWLVHRDGF SLASQLKSEE LSLPEGKARV KLDHDGAILD VDEDDIEKAN
410 420 430 440 450
APSCDRLEDL ASLVYLNESS VLHTLRQRYG ASLLHTYAGP SLLVLSTRGA
460 470 480 490 500
PAVYSEKVMH MFKGCRREDM APHIYAVAQT AYRAMLMSRQ DQSIVLLGSS
510 520 530 540 550
GSGKTTSFQH LVQYLATIAG TSGTKVFSVE KWQALSTLLE AFGNSPTIMN
560 570 580 590 600
GSATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY
610 620 630 640 650
LLACGDATLR TELHLNHLAE NNVFGIVPLS KPEEKQKAAQ QFSKLQAAMK
660 670 680 690 700
VLAISPEEQK TCWLILASIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY
710 720 730 740 750
LLGCSLEELS SAIFKHQLKG GTLQRSTSFR QGPEESGLGE GTKLSALECL
760 770 780 790 800
EGMASGLYSE LFTLLISLVN RALKSSQHSL CSMMIVDTPG FQNPEWGGSA
810 820 830 840 850
RGASFEELCH NYAQDRLQRL FHERTFLQEL ERYKEDNIEL AFDDLEPVAD
860 870 880 890 900
DSVAAVDQAS HLVRSLAHAD EARGLLWLLE EEALVPGATE DALLDRLFSY
910 920 930 940 950
YGPQEGDKKG QSPLLRSSKP RHFLLGHSHG TNWVEYNVAG WLNYTKQNPA
960 970 980 990 1000
TQNAPRLLQD SQKKIISNLF LGRAGSATVL SGSIAGLEGG SQLALRRATS
1010 1020 1030 1040 1050
MRKTFTTGMA AVKKKSLCIQ IKLQVDALID TIKRSKMHFV HCFLPVAEGW
1060 1070 1080 1090 1100
PGEPRSASSR RVSSSSELDL PPGDPCEAGL LQLDVSLLRA QLRGSRLLDA
1110 1120 1130 1140 1150
MRMYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVVD EKRAVEELLE
1160 1170 1180 1190 1200
SLDLEKSSCC LGLSRVFFRA GTLARLEEQR DEQTSRHLTL FQAACRGYLA
1210 1220 1230 1240 1250
RQHFKKRKIQ DLAIRCVQKN IKKNKGVKDW PWWKLFTTVR PLIQVQLSEE
1260 1270 1280 1290 1300
QIRNKDEEIQ QLRSKLEKVE KERNELRLSS DRLETRISEL TSELTDERNT
1310 1320 1330 1340 1350
GESASQLLDA ETAERLRTEK EMKELQTQYD ALKKQMEVME MEVMEARLIR
1360 1370 1380 1390 1400
AAEINGEVDD DDAGGEWRLK YERAVREVDF TKKRLQQELE DKMEVEQQSR
1410 1420 1430 1440 1450
RQLERRLGDL QADSDESQRA LQQLKKKCQR LTAELQDTKL HLEGQQVRNH
1460 1470 1480 1490 1500
ELEKKQRRFD SELSQAHEET QREKLQREKL QREKDMLLAE AFSLKQQMEE
1510 1520 1530 1540 1550
KDLDIAGFTQ KVVSLEAELQ DISSQESKDE ASLAKVKKQL RDLEAKVKDQ
1560 1570 1580 1590 1600
EEELDEQAGS IQMLEQAKLR LEMEMERMRQ THSKEMESRD EEVEEARQSC
1610 1620 1630 1640 1650
QKKLKQMEVQ LEEEYEDKQK ALREKRELES KLSTLSDQVN QRDFESEKRL
1660 1670 1680 1690 1700
RKDLKRTKAL LADAQIMLDH LKNNAPSKRE IAQLKNQLEE SEFTCAAAVK
1710 1720 1730 1740 1750
ARKAMEVEME DLHLQIDDIA KAKTALEEQL SRLQREKNEI QNRLEEDQED
1760 1770 1780 1790 1800
MNELMKKHKA AVAQASRDMA QMNDLQAQIE ESNKEKQELQ EKLQALQSQV
1810 1820 1830 1840 1850
EFLEQSMVDK SLVSRQEAKI RELETRLEFE KTQVKRLENL ASRLKETMEK
1860 1870 1880 1890 1900
LTEERDQRAA AENREKEQNK RLQRQLRDTK EEMSELARKE AEASRKKHEL
1910 1920 1930 1940 1950
EMDLESLEAA NQSLQADLKL AFKRIGDLQA AIEDEMESDE NEDLINSLQD
1960 1970 1980 1990 2000
MVTKYQKKKN KLEGDSDVDS ELEDRVDGVK SWLSKNKGPS KAPSDDGSLK
2010 2020 2030 2040 2050
SSSPTSHWKP LAPDPSDDEH DPVDSISRPR FSHSYLSDSD TEAKLTETSA
Length:2,050
Mass (Da):232,755
Last modified:February 6, 2007 - v2
Checksum:i3D82B901F03D73B4
GO
Isoform 1 (identifier: Q9JMH9-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1948-1962: Missing.

Show »
Length:2,035
Mass (Da):230,908
Checksum:iC5CE4BB053475119
GO
Isoform 2 (identifier: Q9JMH9-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML

Show »
Length:1,719
Mass (Da):195,894
Checksum:iF533D2057E1E555A
GO
Isoform 4 (identifier: Q9JMH9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1567-1603: Missing.
     1948-1962: Missing.

Show »
Length:1,998
Mass (Da):226,357
Checksum:i78A7FB6FF72A32D1
GO
Isoform 5 (identifier: Q9JMH9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML
     1948-1962: Missing.

Show »
Length:1,704
Mass (Da):194,047
Checksum:i494995EAC30B1C00
GO
Isoform 6 (identifier: Q9JMH9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-333: D → DLDPEAASPAYSQ

Show »
Length:2,062
Mass (Da):233,985
Checksum:i823FB756634D16B9
GO
Isoform 7 (identifier: Q9JMH9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → MLLDPEAASPAYSQ
     1948-1962: Missing.

Show »
Length:1,716
Mass (Da):195,277
Checksum:i893846897B291215
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti399A → T in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti466R → Q in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti680 – 683Missing in BAE42402 (PubMed:16141072).Curated4
Sequence conflicti680E → EPLEEQD in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti798G → D in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti1362D → N in BAE42402 (PubMed:16141072).Curated1
Sequence conflicti1655K → R in BAE28009 (PubMed:16141072).Curated1
Sequence conflicti1978G → R in AAV80766 (PubMed:16087679).Curated1
Sequence conflicti1990S → P in AAV80765 (PubMed:16087679).Curated1
Sequence conflicti2027S → F in AAV80767 (PubMed:16087679).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078731 – 331Missing in isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_007874332 – 333AD → ML in isoform 2 and isoform 5. 1 Publication2
Alternative sequenceiVSP_023059332 – 333AD → MLLDPEAASPAYSQ in isoform 7. Curated2
Alternative sequenceiVSP_023060333D → DLDPEAASPAYSQ in isoform 6. Curated1
Alternative sequenceiVSP_0230611567 – 1603Missing in isoform 4. CuratedAdd BLAST37
Alternative sequenceiVSP_0230621948 – 1962Missing in isoform 1, isoform 4, isoform 5 and isoform 7. 4 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026497 mRNA. Translation: BAA93660.1.
AK137574 mRNA. Translation: BAE23413.1.
AK147584 mRNA. Translation: BAE28009.1.
AK171342 mRNA. Translation: BAE42402.1.
AL591065 Genomic DNA. No translation available.
BC046638 mRNA. Translation: AAH46638.1.
AY692137 mRNA. Translation: AAV80765.1.
AY692138 mRNA. Translation: AAV80766.1.
AY692139 mRNA. Translation: AAV80767.1.
CCDSiCCDS25085.1. [Q9JMH9-1]
RefSeqiNP_001278141.1. NM_001291212.1.
NP_001278142.1. NM_001291213.1.
NP_001278143.1. NM_001291214.1.
NP_001278144.1. NM_001291215.1.
NP_035716.1. NM_011586.3. [Q9JMH9-1]
XP_006533667.1. XM_006533604.3. [Q9JMH9-3]
XP_006533669.1. XM_006533606.2. [Q9JMH9-1]
XP_006533677.2. XM_006533614.3. [Q9JMH9-2]
XP_017170115.1. XM_017314626.1. [Q9JMH9-6]
UniGeneiMm.341248.
Mm.476162.

Genome annotation databases

EnsembliENSMUST00000092884; ENSMUSP00000090560; ENSMUSG00000000631. [Q9JMH9-5]
ENSMUST00000092887; ENSMUSP00000090563; ENSMUSG00000000631. [Q9JMH9-1]
ENSMUST00000102488; ENSMUSP00000099546; ENSMUSG00000000631. [Q9JMH9-1]
ENSMUST00000108375; ENSMUSP00000104012; ENSMUSG00000000631. [Q9JMH9-3]
ENSMUST00000108376; ENSMUSP00000104013; ENSMUSG00000000631. [Q9JMH9-4]
ENSMUST00000130305; ENSMUSP00000119574; ENSMUSG00000000631. [Q9JMH9-7]
ENSMUST00000130627; ENSMUSP00000119839; ENSMUSG00000000631. [Q9JMH9-6]
ENSMUST00000164334; ENSMUSP00000131771; ENSMUSG00000000631. [Q9JMH9-2]
GeneIDi360013.
KEGGimmu:360013.
UCSCiuc007khg.2. mouse. [Q9JMH9-1]
uc007khh.2. mouse. [Q9JMH9-5]
uc007khi.2. mouse. [Q9JMH9-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026497 mRNA. Translation: BAA93660.1.
AK137574 mRNA. Translation: BAE23413.1.
AK147584 mRNA. Translation: BAE28009.1.
AK171342 mRNA. Translation: BAE42402.1.
AL591065 Genomic DNA. No translation available.
BC046638 mRNA. Translation: AAH46638.1.
AY692137 mRNA. Translation: AAV80765.1.
AY692138 mRNA. Translation: AAV80766.1.
AY692139 mRNA. Translation: AAV80767.1.
CCDSiCCDS25085.1. [Q9JMH9-1]
RefSeqiNP_001278141.1. NM_001291212.1.
NP_001278142.1. NM_001291213.1.
NP_001278143.1. NM_001291214.1.
NP_001278144.1. NM_001291215.1.
NP_035716.1. NM_011586.3. [Q9JMH9-1]
XP_006533667.1. XM_006533604.3. [Q9JMH9-3]
XP_006533669.1. XM_006533606.2. [Q9JMH9-1]
XP_006533677.2. XM_006533614.3. [Q9JMH9-2]
XP_017170115.1. XM_017314626.1. [Q9JMH9-6]
UniGeneiMm.341248.
Mm.476162.

3D structure databases

ProteinModelPortaliQ9JMH9.
SMRiQ9JMH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237427. 3 interactors.
IntActiQ9JMH9. 6 interactors.
MINTiMINT-1634736.
STRINGi10090.ENSMUSP00000090563.

PTM databases

iPTMnetiQ9JMH9.
PhosphoSitePlusiQ9JMH9.

Proteomic databases

MaxQBiQ9JMH9.
PaxDbiQ5QD54.
Q9JMH9.
PeptideAtlasiQ9JMH9.
PRIDEiQ9JMH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092884; ENSMUSP00000090560; ENSMUSG00000000631. [Q9JMH9-5]
ENSMUST00000092887; ENSMUSP00000090563; ENSMUSG00000000631. [Q9JMH9-1]
ENSMUST00000102488; ENSMUSP00000099546; ENSMUSG00000000631. [Q9JMH9-1]
ENSMUST00000108375; ENSMUSP00000104012; ENSMUSG00000000631. [Q9JMH9-3]
ENSMUST00000108376; ENSMUSP00000104013; ENSMUSG00000000631. [Q9JMH9-4]
ENSMUST00000130305; ENSMUSP00000119574; ENSMUSG00000000631. [Q9JMH9-7]
ENSMUST00000130627; ENSMUSP00000119839; ENSMUSG00000000631. [Q9JMH9-6]
ENSMUST00000164334; ENSMUSP00000131771; ENSMUSG00000000631. [Q9JMH9-2]
GeneIDi360013.
KEGGimmu:360013.
UCSCiuc007khg.2. mouse. [Q9JMH9-1]
uc007khh.2. mouse. [Q9JMH9-5]
uc007khi.2. mouse. [Q9JMH9-7]

Organism-specific databases

CTDi399687.
MGIiMGI:2667185. Myo18a.

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133702.
HOVERGENiHBG052543.
InParanoidiQ9JMH9.
KOiK10362.
PhylomeDBiQ9JMH9.

Miscellaneous databases

ChiTaRSiMyo18a. mouse.
PROiQ9JMH9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000631.
CleanExiMM_MYO18A.
ExpressionAtlasiQ9JMH9. baseline and differential.
GenevisibleiQ9JMH9. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMY18A_MOUSE
AccessioniPrimary (citable) accession number: Q9JMH9
Secondary accession number(s): Q3TBB2
, Q3UH48, Q3UV60, Q5QD54, Q5QD55, Q5QD56, Q5SYN8, Q5SYN9, Q5SYP0, Q5SYP1, Q811D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.