Q9JMH9 (MY18A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-XVIIIa

Alternative name(s):
Molecule associated with JAK3 N-terminus
Short name=MAJN
Myosin containing a PDZ domain

Gene names

Name:	Myo18a
Synonyms:	Myspdz

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2050 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the maintenance of the stromal cell architecture required for cell to cell contact. Isoform 1 may be related to adherence and/or some other functions of mature macrophages. In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration By similarity.
Subunit structure	Homodimer. Interacts with JAK3 and actin. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A By similarity. Ref.5 Ref.8
Subcellular location	Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm › cytoskeleton. Note: Colocalizes with actin. Ref.8 Isoform 2: Cytoplasm. Note: Lacks the PDZ domain. Diffusely localized in the cytoplasm. Ref.8
Tissue specificity	Isoform 1 is expressed ubiquitously. Isoform 2 is specifically expressed in most hematopoietic cells.
Post-translational modification	Phosphorylated on tyrosine upon CSF1R activation. Isoform 6 is phosphorylated on Ser-340. Ref.7
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actomyosin structure organization Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara
Cellular_component	actomyosin Inferred from electronic annotation. Source: Compara cytoskeleton Inferred from direct assay Ref.1. Source: MGI endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell myosin complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9JMH9-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9JMH9-1)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1948-1962: Missing.

Isoform 2 (identifier: Q9JMH9-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML

Isoform 4 (identifier: Q9JMH9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1567-1603: Missing.
     1948-1962: Missing.

Isoform 5 (identifier: Q9JMH9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → ML
     1948-1962: Missing.

Isoform 6 (identifier: Q9JMH9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     333-333: D → DLDPEAASPAYSQ

Note: Phosphorylated at position 340.

Isoform 7 (identifier: Q9JMH9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.
     332-333: AD → MLLDPEAASPAYSQ
     1948-1962: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2050	2050	Unconventional myosin-XVIIIa		PRO_0000123477
Regions
	Domain	220 – 311	92	PDZ
	Domain	407 – 1169	763	Myosin head-like
	Domain	1184 – 1213	30	IQ
	Nucleotide binding	498 – 505	8	ATP Potential
	Coiled coil	1242 – 1967	726	Potential
	Motif	114 – 118	5	Interaction with actin By similarity
Amino acid modifications
	Modified residue	72	1	Phosphoserine Ref.11
	Modified residue	74	1	Phosphoserine Ref.11
	Modified residue	83	1	Phosphoserine Ref.11 Ref.12
	Modified residue	102	1	Phosphoserine Ref.11
	Modified residue	140	1	Phosphoserine By similarity
	Modified residue	164	1	Phosphoserine Ref.11
	Modified residue	1066	1	Phosphoserine By similarity
	Modified residue	1966	1	Phosphoserine Ref.9 Ref.11 Ref.12 Ref.13
	Modified residue	1970	1	Phosphoserine Ref.9 Ref.12 Ref.13
	Modified residue	1994	1	Phosphoserine By similarity
	Modified residue	1998	1	Phosphoserine By similarity
	Modified residue	2003	1	Phosphoserine By similarity
	Modified residue	2016	1	Phosphoserine Ref.12
	Modified residue	2032	1	Phosphoserine Ref.11
	Modified residue	2037	1	Phosphoserine Ref.11 Ref.12
	Modified residue	2039	1	Phosphoserine Ref.11 Ref.12
	Modified residue	2041	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 331	331	Missing in isoform 2, isoform 5 and isoform 7.		VSP_007873
	Alternative sequence	332 – 333	2	AD → ML in isoform 2 and isoform 5.		VSP_007874
	Alternative sequence	332 – 333	2	AD → MLLDPEAASPAYSQ in isoform 7.		VSP_023059
	Alternative sequence	333	1	D → DLDPEAASPAYSQ in isoform 6.		VSP_023060
	Alternative sequence	1567 – 1603	37	Missing in isoform 4.		VSP_023061
	Alternative sequence	1948 – 1962	15	Missing in isoform 1, isoform 4, isoform 5 and isoform 7.		VSP_023062
Experimental info
	Sequence conflict	399	1	A → T in BAE28009. Ref.2
	Sequence conflict	466	1	R → Q in BAE42402. Ref.2
	Sequence conflict	680 – 683	4	Missing in BAE42402. Ref.2
	Sequence conflict	680	1	E → EPLEEQD in BAE28009. Ref.2
	Sequence conflict	798	1	G → D in BAE42402. Ref.2
	Sequence conflict	1362	1	D → N in BAE42402. Ref.2
	Sequence conflict	1655	1	K → R in BAE28009. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 3D82B901F03D73B4	FASTA	2,050	232,755
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 190 200 210 220 230 240 GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADAKTEEQI AAEEAWYETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LSLPEGKARV KLDHDGAILD VDEDDIEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLSTRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIVLLGSS GSGKTTSFQH LVQYLATIAG TSGTKVFSVE KWQALSTLLE 550 560 570 580 590 600 AFGNSPTIMN GSATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDATLR TELHLNHLAE NNVFGIVPLS KPEEKQKAAQ QFSKLQAAMK VLAISPEEQK 670 680 690 700 710 720 TCWLILASIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQLKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGE GTKLSALECL EGMASGLYSE LFTLLISLVN RALKSSQHSL 790 800 810 820 830 840 CSMMIVDTPG FQNPEWGGSA RGASFEELCH NYAQDRLQRL FHERTFLQEL ERYKEDNIEL 850 860 870 880 890 900 AFDDLEPVAD DSVAAVDQAS HLVRSLAHAD EARGLLWLLE EEALVPGATE DALLDRLFSY 910 920 930 940 950 960 YGPQEGDKKG QSPLLRSSKP RHFLLGHSHG TNWVEYNVAG WLNYTKQNPA TQNAPRLLQD 970 980 990 1000 1010 1020 SQKKIISNLF LGRAGSATVL SGSIAGLEGG SQLALRRATS MRKTFTTGMA AVKKKSLCIQ 1030 1040 1050 1060 1070 1080 IKLQVDALID TIKRSKMHFV HCFLPVAEGW PGEPRSASSR RVSSSSELDL PPGDPCEAGL 1090 1100 1110 1120 1130 1140 LQLDVSLLRA QLRGSRLLDA MRMYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVVD 1150 1160 1170 1180 1190 1200 EKRAVEELLE SLDLEKSSCC LGLSRVFFRA GTLARLEEQR DEQTSRHLTL FQAACRGYLA 1210 1220 1230 1240 1250 1260 RQHFKKRKIQ DLAIRCVQKN IKKNKGVKDW PWWKLFTTVR PLIQVQLSEE QIRNKDEEIQ 1270 1280 1290 1300 1310 1320 QLRSKLEKVE KERNELRLSS DRLETRISEL TSELTDERNT GESASQLLDA ETAERLRTEK 1330 1340 1350 1360 1370 1380 EMKELQTQYD ALKKQMEVME MEVMEARLIR AAEINGEVDD DDAGGEWRLK YERAVREVDF 1390 1400 1410 1420 1430 1440 TKKRLQQELE DKMEVEQQSR RQLERRLGDL QADSDESQRA LQQLKKKCQR LTAELQDTKL 1450 1460 1470 1480 1490 1500 HLEGQQVRNH ELEKKQRRFD SELSQAHEET QREKLQREKL QREKDMLLAE AFSLKQQMEE 1510 1520 1530 1540 1550 1560 KDLDIAGFTQ KVVSLEAELQ DISSQESKDE ASLAKVKKQL RDLEAKVKDQ EEELDEQAGS 1570 1580 1590 1600 1610 1620 IQMLEQAKLR LEMEMERMRQ THSKEMESRD EEVEEARQSC QKKLKQMEVQ LEEEYEDKQK 1630 1640 1650 1660 1670 1680 ALREKRELES KLSTLSDQVN QRDFESEKRL RKDLKRTKAL LADAQIMLDH LKNNAPSKRE 1690 1700 1710 1720 1730 1740 IAQLKNQLEE SEFTCAAAVK ARKAMEVEME DLHLQIDDIA KAKTALEEQL SRLQREKNEI 1750 1760 1770 1780 1790 1800 QNRLEEDQED MNELMKKHKA AVAQASRDMA QMNDLQAQIE ESNKEKQELQ EKLQALQSQV 1810 1820 1830 1840 1850 1860 EFLEQSMVDK SLVSRQEAKI RELETRLEFE KTQVKRLENL ASRLKETMEK LTEERDQRAA 1870 1880 1890 1900 1910 1920 AENREKEQNK RLQRQLRDTK EEMSELARKE AEASRKKHEL EMDLESLEAA NQSLQADLKL 1930 1940 1950 1960 1970 1980 AFKRIGDLQA AIEDEMESDE NEDLINSLQD MVTKYQKKKN KLEGDSDVDS ELEDRVDGVK 1990 2000 2010 2020 2030 2040 SWLSKNKGPS KAPSDDGSLK SSSPTSHWKP LAPDPSDDEH DPVDSISRPR FSHSYLSDSD 2050 TEAKLTETSA
	Isoform 1 (Alpha) [UniParc]. Checksum: C5CE4BB053475119	FASTA	2,035	230,908
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 190 200 210 220 230 240 GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADAKTEEQI AAEEAWYETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LSLPEGKARV KLDHDGAILD VDEDDIEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLSTRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIVLLGSS GSGKTTSFQH LVQYLATIAG TSGTKVFSVE KWQALSTLLE 550 560 570 580 590 600 AFGNSPTIMN GSATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDATLR TELHLNHLAE NNVFGIVPLS KPEEKQKAAQ QFSKLQAAMK VLAISPEEQK 670 680 690 700 710 720 TCWLILASIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQLKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGE GTKLSALECL EGMASGLYSE LFTLLISLVN RALKSSQHSL 790 800 810 820 830 840 CSMMIVDTPG FQNPEWGGSA RGASFEELCH NYAQDRLQRL FHERTFLQEL ERYKEDNIEL 850 860 870 880 890 900 AFDDLEPVAD DSVAAVDQAS HLVRSLAHAD EARGLLWLLE EEALVPGATE DALLDRLFSY 910 920 930 940 950 960 YGPQEGDKKG QSPLLRSSKP RHFLLGHSHG TNWVEYNVAG WLNYTKQNPA TQNAPRLLQD 970 980 990 1000 1010 1020 SQKKIISNLF LGRAGSATVL SGSIAGLEGG SQLALRRATS MRKTFTTGMA AVKKKSLCIQ 1030 1040 1050 1060 1070 1080 IKLQVDALID TIKRSKMHFV HCFLPVAEGW PGEPRSASSR RVSSSSELDL PPGDPCEAGL 1090 1100 1110 1120 1130 1140 LQLDVSLLRA QLRGSRLLDA MRMYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVVD 1150 1160 1170 1180 1190 1200 EKRAVEELLE SLDLEKSSCC LGLSRVFFRA GTLARLEEQR DEQTSRHLTL FQAACRGYLA 1210 1220 1230 1240 1250 1260 RQHFKKRKIQ DLAIRCVQKN IKKNKGVKDW PWWKLFTTVR PLIQVQLSEE QIRNKDEEIQ 1270 1280 1290 1300 1310 1320 QLRSKLEKVE KERNELRLSS DRLETRISEL TSELTDERNT GESASQLLDA ETAERLRTEK 1330 1340 1350 1360 1370 1380 EMKELQTQYD ALKKQMEVME MEVMEARLIR AAEINGEVDD DDAGGEWRLK YERAVREVDF 1390 1400 1410 1420 1430 1440 TKKRLQQELE DKMEVEQQSR RQLERRLGDL QADSDESQRA LQQLKKKCQR LTAELQDTKL 1450 1460 1470 1480 1490 1500 HLEGQQVRNH ELEKKQRRFD SELSQAHEET QREKLQREKL QREKDMLLAE AFSLKQQMEE 1510 1520 1530 1540 1550 1560 KDLDIAGFTQ KVVSLEAELQ DISSQESKDE ASLAKVKKQL RDLEAKVKDQ EEELDEQAGS 1570 1580 1590 1600 1610 1620 IQMLEQAKLR LEMEMERMRQ THSKEMESRD EEVEEARQSC QKKLKQMEVQ LEEEYEDKQK 1630 1640 1650 1660 1670 1680 ALREKRELES KLSTLSDQVN QRDFESEKRL RKDLKRTKAL LADAQIMLDH LKNNAPSKRE 1690 1700 1710 1720 1730 1740 IAQLKNQLEE SEFTCAAAVK ARKAMEVEME DLHLQIDDIA KAKTALEEQL SRLQREKNEI 1750 1760 1770 1780 1790 1800 QNRLEEDQED MNELMKKHKA AVAQASRDMA QMNDLQAQIE ESNKEKQELQ EKLQALQSQV 1810 1820 1830 1840 1850 1860 EFLEQSMVDK SLVSRQEAKI RELETRLEFE KTQVKRLENL ASRLKETMEK LTEERDQRAA 1870 1880 1890 1900 1910 1920 AENREKEQNK RLQRQLRDTK EEMSELARKE AEASRKKHEL EMDLESLEAA NQSLQADLKL 1930 1940 1950 1960 1970 1980 AFKRIGDLQA AIEDEMESDE NEDLINSEGD SDVDSELEDR VDGVKSWLSK NKGPSKAPSD 1990 2000 2010 2020 2030 DGSLKSSSPT SHWKPLAPDP SDDEHDPVDS ISRPRFSHSY LSDSDTEAKL TETSA
	Isoform 2 (Beta) [UniParc]. Checksum: F533D2057E1E555A	FASTA	1,719	195,894
	10 20 30 40 50 60 MLAKTEEQIA AEEAWYETEK VWLVHRDGFS LASQLKSEEL SLPEGKARVK LDHDGAILDV 70 80 90 100 110 120 DEDDIEKANA PSCDRLEDLA SLVYLNESSV LHTLRQRYGA SLLHTYAGPS LLVLSTRGAP 130 140 150 160 170 180 AVYSEKVMHM FKGCRREDMA PHIYAVAQTA YRAMLMSRQD QSIVLLGSSG SGKTTSFQHL 190 200 210 220 230 240 VQYLATIAGT SGTKVFSVEK WQALSTLLEA FGNSPTIMNG SATRFSQILS LDFDQAGQVA 250 260 270 280 290 300 SASIQTMLLE KLRVARRPAS EATFNVFYYL LACGDATLRT ELHLNHLAEN NVFGIVPLSK 310 320 330 340 350 360 PEEKQKAAQQ FSKLQAAMKV LAISPEEQKT CWLILASIYH LGAAGATKEA AEAGRKQFAR 370 380 390 400 410 420 HEWAQKAAYL LGCSLEELSS AIFKHQLKGG TLQRSTSFRQ GPEESGLGEG TKLSALECLE 430 440 450 460 470 480 GMASGLYSEL FTLLISLVNR ALKSSQHSLC SMMIVDTPGF QNPEWGGSAR GASFEELCHN 490 500 510 520 530 540 YAQDRLQRLF HERTFLQELE RYKEDNIELA FDDLEPVADD SVAAVDQASH LVRSLAHADE 550 560 570 580 590 600 ARGLLWLLEE EALVPGATED ALLDRLFSYY GPQEGDKKGQ SPLLRSSKPR HFLLGHSHGT 610 620 630 640 650 660 NWVEYNVAGW LNYTKQNPAT QNAPRLLQDS QKKIISNLFL GRAGSATVLS GSIAGLEGGS 670 680 690 700 710 720 QLALRRATSM RKTFTTGMAA VKKKSLCIQI KLQVDALIDT IKRSKMHFVH CFLPVAEGWP 730 740 750 760 770 780 GEPRSASSRR VSSSSELDLP PGDPCEAGLL QLDVSLLRAQ LRGSRLLDAM RMYRQGYPDH 790 800 810 820 830 840 MVFSEFRRRF DVLAPHLTKK HGRNYIVVDE KRAVEELLES LDLEKSSCCL GLSRVFFRAG 850 860 870 880 890 900 TLARLEEQRD EQTSRHLTLF QAACRGYLAR QHFKKRKIQD LAIRCVQKNI KKNKGVKDWP 910 920 930 940 950 960 WWKLFTTVRP LIQVQLSEEQ IRNKDEEIQQ LRSKLEKVEK ERNELRLSSD RLETRISELT 970 980 990 1000 1010 1020 SELTDERNTG ESASQLLDAE TAERLRTEKE MKELQTQYDA LKKQMEVMEM EVMEARLIRA 1030 1040 1050 1060 1070 1080 AEINGEVDDD DAGGEWRLKY ERAVREVDFT KKRLQQELED KMEVEQQSRR QLERRLGDLQ 1090 1100 1110 1120 1130 1140 ADSDESQRAL QQLKKKCQRL TAELQDTKLH LEGQQVRNHE LEKKQRRFDS ELSQAHEETQ 1150 1160 1170 1180 1190 1200 REKLQREKLQ REKDMLLAEA FSLKQQMEEK DLDIAGFTQK VVSLEAELQD ISSQESKDEA 1210 1220 1230 1240 1250 1260 SLAKVKKQLR DLEAKVKDQE EELDEQAGSI QMLEQAKLRL EMEMERMRQT HSKEMESRDE 1270 1280 1290 1300 1310 1320 EVEEARQSCQ KKLKQMEVQL EEEYEDKQKA LREKRELESK LSTLSDQVNQ RDFESEKRLR 1330 1340 1350 1360 1370 1380 KDLKRTKALL ADAQIMLDHL KNNAPSKREI AQLKNQLEES EFTCAAAVKA RKAMEVEMED 1390 1400 1410 1420 1430 1440 LHLQIDDIAK AKTALEEQLS RLQREKNEIQ NRLEEDQEDM NELMKKHKAA VAQASRDMAQ 1450 1460 1470 1480 1490 1500 MNDLQAQIEE SNKEKQELQE KLQALQSQVE FLEQSMVDKS LVSRQEAKIR ELETRLEFEK 1510 1520 1530 1540 1550 1560 TQVKRLENLA SRLKETMEKL TEERDQRAAA ENREKEQNKR LQRQLRDTKE EMSELARKEA 1570 1580 1590 1600 1610 1620 EASRKKHELE MDLESLEAAN QSLQADLKLA FKRIGDLQAA IEDEMESDEN EDLINSLQDM 1630 1640 1650 1660 1670 1680 VTKYQKKKNK LEGDSDVDSE LEDRVDGVKS WLSKNKGPSK APSDDGSLKS SSPTSHWKPL 1690 1700 1710 APDPSDDEHD PVDSISRPRF SHSYLSDSDT EAKLTETSA
	Isoform 4 [UniParc]. Checksum: 78A7FB6FF72A32D1	FASTA	1,998	226,357
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 190 200 210 220 230 240 GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADAKTEEQI AAEEAWYETE KVWLVHRDGF 370 380 390 400 410 420 SLASQLKSEE LSLPEGKARV KLDHDGAILD VDEDDIEKAN APSCDRLEDL ASLVYLNESS 430 440 450 460 470 480 VLHTLRQRYG ASLLHTYAGP SLLVLSTRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 490 500 510 520 530 540 AYRAMLMSRQ DQSIVLLGSS GSGKTTSFQH LVQYLATIAG TSGTKVFSVE KWQALSTLLE 550 560 570 580 590 600 AFGNSPTIMN GSATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 610 620 630 640 650 660 LLACGDATLR TELHLNHLAE NNVFGIVPLS KPEEKQKAAQ QFSKLQAAMK VLAISPEEQK 670 680 690 700 710 720 TCWLILASIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQLKG 730 740 750 760 770 780 GTLQRSTSFR QGPEESGLGE GTKLSALECL EGMASGLYSE LFTLLISLVN RALKSSQHSL 790 800 810 820 830 840 CSMMIVDTPG FQNPEWGGSA RGASFEELCH NYAQDRLQRL FHERTFLQEL ERYKEDNIEL 850 860 870 880 890 900 AFDDLEPVAD DSVAAVDQAS HLVRSLAHAD EARGLLWLLE EEALVPGATE DALLDRLFSY 910 920 930 940 950 960 YGPQEGDKKG QSPLLRSSKP RHFLLGHSHG TNWVEYNVAG WLNYTKQNPA TQNAPRLLQD 970 980 990 1000 1010 1020 SQKKIISNLF LGRAGSATVL SGSIAGLEGG SQLALRRATS MRKTFTTGMA AVKKKSLCIQ 1030 1040 1050 1060 1070 1080 IKLQVDALID TIKRSKMHFV HCFLPVAEGW PGEPRSASSR RVSSSSELDL PPGDPCEAGL 1090 1100 1110 1120 1130 1140 LQLDVSLLRA QLRGSRLLDA MRMYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVVD 1150 1160 1170 1180 1190 1200 EKRAVEELLE SLDLEKSSCC LGLSRVFFRA GTLARLEEQR DEQTSRHLTL FQAACRGYLA 1210 1220 1230 1240 1250 1260 RQHFKKRKIQ DLAIRCVQKN IKKNKGVKDW PWWKLFTTVR PLIQVQLSEE QIRNKDEEIQ 1270 1280 1290 1300 1310 1320 QLRSKLEKVE KERNELRLSS DRLETRISEL TSELTDERNT GESASQLLDA ETAERLRTEK 1330 1340 1350 1360 1370 1380 EMKELQTQYD ALKKQMEVME MEVMEARLIR AAEINGEVDD DDAGGEWRLK YERAVREVDF 1390 1400 1410 1420 1430 1440 TKKRLQQELE DKMEVEQQSR RQLERRLGDL QADSDESQRA LQQLKKKCQR LTAELQDTKL 1450 1460 1470 1480 1490 1500 HLEGQQVRNH ELEKKQRRFD SELSQAHEET QREKLQREKL QREKDMLLAE AFSLKQQMEE 1510 1520 1530 1540 1550 1560 KDLDIAGFTQ KVVSLEAELQ DISSQESKDE ASLAKVKKQL RDLEAKVKDQ EEELDEQAGS 1570 1580 1590 1600 1610 1620 IQMLEQLKQM EVQLEEEYED KQKALREKRE LESKLSTLSD QVNQRDFESE KRLRKDLKRT 1630 1640 1650 1660 1670 1680 KALLADAQIM LDHLKNNAPS KREIAQLKNQ LEESEFTCAA AVKARKAMEV EMEDLHLQID 1690 1700 1710 1720 1730 1740 DIAKAKTALE EQLSRLQREK NEIQNRLEED QEDMNELMKK HKAAVAQASR DMAQMNDLQA 1750 1760 1770 1780 1790 1800 QIEESNKEKQ ELQEKLQALQ SQVEFLEQSM VDKSLVSRQE AKIRELETRL EFEKTQVKRL 1810 1820 1830 1840 1850 1860 ENLASRLKET MEKLTEERDQ RAAAENREKE QNKRLQRQLR DTKEEMSELA RKEAEASRKK 1870 1880 1890 1900 1910 1920 HELEMDLESL EAANQSLQAD LKLAFKRIGD LQAAIEDEME SDENEDLINS EGDSDVDSEL 1930 1940 1950 1960 1970 1980 EDRVDGVKSW LSKNKGPSKA PSDDGSLKSS SPTSHWKPLA PDPSDDEHDP VDSISRPRFS 1990 HSYLSDSDTE AKLTETSA
	Isoform 5 [UniParc]. Checksum: 494995EAC30B1C00	FASTA	1,704	194,047
	10 20 30 40 50 60 MLAKTEEQIA AEEAWYETEK VWLVHRDGFS LASQLKSEEL SLPEGKARVK LDHDGAILDV 70 80 90 100 110 120 DEDDIEKANA PSCDRLEDLA SLVYLNESSV LHTLRQRYGA SLLHTYAGPS LLVLSTRGAP 130 140 150 160 170 180 AVYSEKVMHM FKGCRREDMA PHIYAVAQTA YRAMLMSRQD QSIVLLGSSG SGKTTSFQHL 190 200 210 220 230 240 VQYLATIAGT SGTKVFSVEK WQALSTLLEA FGNSPTIMNG SATRFSQILS LDFDQAGQVA 250 260 270 280 290 300 SASIQTMLLE KLRVARRPAS EATFNVFYYL LACGDATLRT ELHLNHLAEN NVFGIVPLSK 310 320 330 340 350 360 PEEKQKAAQQ FSKLQAAMKV LAISPEEQKT CWLILASIYH LGAAGATKEA AEAGRKQFAR 370 380 390 400 410 420 HEWAQKAAYL LGCSLEELSS AIFKHQLKGG TLQRSTSFRQ GPEESGLGEG TKLSALECLE 430 440 450 460 470 480 GMASGLYSEL FTLLISLVNR ALKSSQHSLC SMMIVDTPGF QNPEWGGSAR GASFEELCHN 490 500 510 520 530 540 YAQDRLQRLF HERTFLQELE RYKEDNIELA FDDLEPVADD SVAAVDQASH LVRSLAHADE 550 560 570 580 590 600 ARGLLWLLEE EALVPGATED ALLDRLFSYY GPQEGDKKGQ SPLLRSSKPR HFLLGHSHGT 610 620 630 640 650 660 NWVEYNVAGW LNYTKQNPAT QNAPRLLQDS QKKIISNLFL GRAGSATVLS GSIAGLEGGS 670 680 690 700 710 720 QLALRRATSM RKTFTTGMAA VKKKSLCIQI KLQVDALIDT IKRSKMHFVH CFLPVAEGWP 730 740 750 760 770 780 GEPRSASSRR VSSSSELDLP PGDPCEAGLL QLDVSLLRAQ LRGSRLLDAM RMYRQGYPDH 790 800 810 820 830 840 MVFSEFRRRF DVLAPHLTKK HGRNYIVVDE KRAVEELLES LDLEKSSCCL GLSRVFFRAG 850 860 870 880 890 900 TLARLEEQRD EQTSRHLTLF QAACRGYLAR QHFKKRKIQD LAIRCVQKNI KKNKGVKDWP 910 920 930 940 950 960 WWKLFTTVRP LIQVQLSEEQ IRNKDEEIQQ LRSKLEKVEK ERNELRLSSD RLETRISELT 970 980 990 1000 1010 1020 SELTDERNTG ESASQLLDAE TAERLRTEKE MKELQTQYDA LKKQMEVMEM EVMEARLIRA 1030 1040 1050 1060 1070 1080 AEINGEVDDD DAGGEWRLKY ERAVREVDFT KKRLQQELED KMEVEQQSRR QLERRLGDLQ 1090 1100 1110 1120 1130 1140 ADSDESQRAL QQLKKKCQRL TAELQDTKLH LEGQQVRNHE LEKKQRRFDS ELSQAHEETQ 1150 1160 1170 1180 1190 1200 REKLQREKLQ REKDMLLAEA FSLKQQMEEK DLDIAGFTQK VVSLEAELQD ISSQESKDEA 1210 1220 1230 1240 1250 1260 SLAKVKKQLR DLEAKVKDQE EELDEQAGSI QMLEQAKLRL EMEMERMRQT HSKEMESRDE 1270 1280 1290 1300 1310 1320 EVEEARQSCQ KKLKQMEVQL EEEYEDKQKA LREKRELESK LSTLSDQVNQ RDFESEKRLR 1330 1340 1350 1360 1370 1380 KDLKRTKALL ADAQIMLDHL KNNAPSKREI AQLKNQLEES EFTCAAAVKA RKAMEVEMED 1390 1400 1410 1420 1430 1440 LHLQIDDIAK AKTALEEQLS RLQREKNEIQ NRLEEDQEDM NELMKKHKAA VAQASRDMAQ 1450 1460 1470 1480 1490 1500 MNDLQAQIEE SNKEKQELQE KLQALQSQVE FLEQSMVDKS LVSRQEAKIR ELETRLEFEK 1510 1520 1530 1540 1550 1560 TQVKRLENLA SRLKETMEKL TEERDQRAAA ENREKEQNKR LQRQLRDTKE EMSELARKEA 1570 1580 1590 1600 1610 1620 EASRKKHELE MDLESLEAAN QSLQADLKLA FKRIGDLQAA IEDEMESDEN EDLINSEGDS 1630 1640 1650 1660 1670 1680 DVDSELEDRV DGVKSWLSKN KGPSKAPSDD GSLKSSSPTS HWKPLAPDPS DDEHDPVDSI 1690 1700 SRPRFSHSYL SDSDTEAKLT ETSA
	Isoform 6 [UniParc]. Checksum: 823FB756634D16B9	FASTA	2,062	233,985
	10 20 30 40 50 60 MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 70 80 90 100 110 120 EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 130 140 150 160 170 180 AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 190 200 210 220 230 240 GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 250 260 270 280 290 300 LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 310 320 330 340 350 360 DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADLDPEAAS PAYSQAKTEE QIAAEEAWYE 370 380 390 400 410 420 TEKVWLVHRD GFSLASQLKS EELSLPEGKA RVKLDHDGAI LDVDEDDIEK ANAPSCDRLE 430 440 450 460 470 480 DLASLVYLNE SSVLHTLRQR YGASLLHTYA GPSLLVLSTR GAPAVYSEKV MHMFKGCRRE 490 500 510 520 530 540 DMAPHIYAVA QTAYRAMLMS RQDQSIVLLG SSGSGKTTSF QHLVQYLATI AGTSGTKVFS 550 560 570 580 590 600 VEKWQALSTL LEAFGNSPTI MNGSATRFSQ ILSLDFDQAG QVASASIQTM LLEKLRVARR 610 620 630 640 650 660 PASEATFNVF YYLLACGDAT LRTELHLNHL AENNVFGIVP LSKPEEKQKA AQQFSKLQAA 670 680 690 700 710 720 MKVLAISPEE QKTCWLILAS IYHLGAAGAT KEAAEAGRKQ FARHEWAQKA AYLLGCSLEE 730 740 750 760 770 780 LSSAIFKHQL KGGTLQRSTS FRQGPEESGL GEGTKLSALE CLEGMASGLY SELFTLLISL 790 800 810 820 830 840 VNRALKSSQH SLCSMMIVDT PGFQNPEWGG SARGASFEEL CHNYAQDRLQ RLFHERTFLQ 850 860 870 880 890 900 ELERYKEDNI ELAFDDLEPV ADDSVAAVDQ ASHLVRSLAH ADEARGLLWL LEEEALVPGA 910 920 930 940 950 960 TEDALLDRLF SYYGPQEGDK KGQSPLLRSS KPRHFLLGHS HGTNWVEYNV AGWLNYTKQN 970 980 990 1000 1010 1020 PATQNAPRLL QDSQKKIISN LFLGRAGSAT VLSGSIAGLE GGSQLALRRA TSMRKTFTTG 1030 1040 1050 1060 1070 1080 MAAVKKKSLC IQIKLQVDAL IDTIKRSKMH FVHCFLPVAE GWPGEPRSAS SRRVSSSSEL 1090 1100 1110 1120 1130 1140 DLPPGDPCEA GLLQLDVSLL RAQLRGSRLL DAMRMYRQGY PDHMVFSEFR RRFDVLAPHL 1150 1160 1170 1180 1190 1200 TKKHGRNYIV VDEKRAVEEL LESLDLEKSS CCLGLSRVFF RAGTLARLEE QRDEQTSRHL 1210 1220 1230 1240 1250 1260 TLFQAACRGY LARQHFKKRK IQDLAIRCVQ KNIKKNKGVK DWPWWKLFTT VRPLIQVQLS 1270 1280 1290 1300 1310 1320 EEQIRNKDEE IQQLRSKLEK VEKERNELRL SSDRLETRIS ELTSELTDER NTGESASQLL 1330 1340 1350 1360 1370 1380 DAETAERLRT EKEMKELQTQ YDALKKQMEV MEMEVMEARL IRAAEINGEV DDDDAGGEWR 1390 1400 1410 1420 1430 1440 LKYERAVREV DFTKKRLQQE LEDKMEVEQQ SRRQLERRLG DLQADSDESQ RALQQLKKKC 1450 1460 1470 1480 1490 1500 QRLTAELQDT KLHLEGQQVR NHELEKKQRR FDSELSQAHE ETQREKLQRE KLQREKDMLL 1510 1520 1530 1540 1550 1560 AEAFSLKQQM EEKDLDIAGF TQKVVSLEAE LQDISSQESK DEASLAKVKK QLRDLEAKVK 1570 1580 1590 1600 1610 1620 DQEEELDEQA GSIQMLEQAK LRLEMEMERM RQTHSKEMES RDEEVEEARQ SCQKKLKQME 1630 1640 1650 1660 1670 1680 VQLEEEYEDK QKALREKREL ESKLSTLSDQ VNQRDFESEK RLRKDLKRTK ALLADAQIML 1690 1700 1710 1720 1730 1740 DHLKNNAPSK REIAQLKNQL EESEFTCAAA VKARKAMEVE MEDLHLQIDD IAKAKTALEE 1750 1760 1770 1780 1790 1800 QLSRLQREKN EIQNRLEEDQ EDMNELMKKH KAAVAQASRD MAQMNDLQAQ IEESNKEKQE 1810 1820 1830 1840 1850 1860 LQEKLQALQS QVEFLEQSMV DKSLVSRQEA KIRELETRLE FEKTQVKRLE NLASRLKETM 1870 1880 1890 1900 1910 1920 EKLTEERDQR AAAENREKEQ NKRLQRQLRD TKEEMSELAR KEAEASRKKH ELEMDLESLE 1930 1940 1950 1960 1970 1980 AANQSLQADL KLAFKRIGDL QAAIEDEMES DENEDLINSL QDMVTKYQKK KNKLEGDSDV 1990 2000 2010 2020 2030 2040 DSELEDRVDG VKSWLSKNKG PSKAPSDDGS LKSSSPTSHW KPLAPDPSDD EHDPVDSISR 2050 2060 PRFSHSYLSD SDTEAKLTET SA
	Isoform 7 [UniParc]. Checksum: 893846897B291215	FASTA	1,716	195,277
	10 20 30 40 50 60 MLLDPEAASP AYSQAKTEEQ IAAEEAWYET EKVWLVHRDG FSLASQLKSE ELSLPEGKAR 70 80 90 100 110 120 VKLDHDGAIL DVDEDDIEKA NAPSCDRLED LASLVYLNES SVLHTLRQRY GASLLHTYAG 130 140 150 160 170 180 PSLLVLSTRG APAVYSEKVM HMFKGCRRED MAPHIYAVAQ TAYRAMLMSR QDQSIVLLGS 190 200 210 220 230 240 SGSGKTTSFQ HLVQYLATIA GTSGTKVFSV EKWQALSTLL EAFGNSPTIM NGSATRFSQI 250 260 270 280 290 300 LSLDFDQAGQ VASASIQTML LEKLRVARRP ASEATFNVFY YLLACGDATL RTELHLNHLA 310 320 330 340 350 360 ENNVFGIVPL SKPEEKQKAA QQFSKLQAAM KVLAISPEEQ KTCWLILASI YHLGAAGATK 370 380 390 400 410 420 EAAEAGRKQF ARHEWAQKAA YLLGCSLEEL SSAIFKHQLK GGTLQRSTSF RQGPEESGLG 430 440 450 460 470 480 EGTKLSALEC LEGMASGLYS ELFTLLISLV NRALKSSQHS LCSMMIVDTP GFQNPEWGGS 490 500 510 520 530 540 ARGASFEELC HNYAQDRLQR LFHERTFLQE LERYKEDNIE LAFDDLEPVA DDSVAAVDQA 550 560 570 580 590 600 SHLVRSLAHA DEARGLLWLL EEEALVPGAT EDALLDRLFS YYGPQEGDKK GQSPLLRSSK 610 620 630 640 650 660 PRHFLLGHSH GTNWVEYNVA GWLNYTKQNP ATQNAPRLLQ DSQKKIISNL FLGRAGSATV 670 680 690 700 710 720 LSGSIAGLEG GSQLALRRAT SMRKTFTTGM AAVKKKSLCI QIKLQVDALI DTIKRSKMHF 730 740 750 760 770 780 VHCFLPVAEG WPGEPRSASS RRVSSSSELD LPPGDPCEAG LLQLDVSLLR AQLRGSRLLD 790 800 810 820 830 840 AMRMYRQGYP DHMVFSEFRR RFDVLAPHLT KKHGRNYIVV DEKRAVEELL ESLDLEKSSC 850 860 870 880 890 900 CLGLSRVFFR AGTLARLEEQ RDEQTSRHLT LFQAACRGYL ARQHFKKRKI QDLAIRCVQK 910 920 930 940 950 960 NIKKNKGVKD WPWWKLFTTV RPLIQVQLSE EQIRNKDEEI QQLRSKLEKV EKERNELRLS 970 980 990 1000 1010 1020 SDRLETRISE LTSELTDERN TGESASQLLD AETAERLRTE KEMKELQTQY DALKKQMEVM 1030 1040 1050 1060 1070 1080 EMEVMEARLI RAAEINGEVD DDDAGGEWRL KYERAVREVD FTKKRLQQEL EDKMEVEQQS 1090 1100 1110 1120 1130 1140 RRQLERRLGD LQADSDESQR ALQQLKKKCQ RLTAELQDTK LHLEGQQVRN HELEKKQRRF 1150 1160 1170 1180 1190 1200 DSELSQAHEE TQREKLQREK LQREKDMLLA EAFSLKQQME EKDLDIAGFT QKVVSLEAEL 1210 1220 1230 1240 1250 1260 QDISSQESKD EASLAKVKKQ LRDLEAKVKD QEEELDEQAG SIQMLEQAKL RLEMEMERMR 1270 1280 1290 1300 1310 1320 QTHSKEMESR DEEVEEARQS CQKKLKQMEV QLEEEYEDKQ KALREKRELE SKLSTLSDQV 1330 1340 1350 1360 1370 1380 NQRDFESEKR LRKDLKRTKA LLADAQIMLD HLKNNAPSKR EIAQLKNQLE ESEFTCAAAV 1390 1400 1410 1420 1430 1440 KARKAMEVEM EDLHLQIDDI AKAKTALEEQ LSRLQREKNE IQNRLEEDQE DMNELMKKHK 1450 1460 1470 1480 1490 1500 AAVAQASRDM AQMNDLQAQI EESNKEKQEL QEKLQALQSQ VEFLEQSMVD KSLVSRQEAK 1510 1520 1530 1540 1550 1560 IRELETRLEF EKTQVKRLEN LASRLKETME KLTEERDQRA AAENREKEQN KRLQRQLRDT 1570 1580 1590 1600 1610 1620 KEEMSELARK EAEASRKKHE LEMDLESLEA ANQSLQADLK LAFKRIGDLQ AAIEDEMESD 1630 1640 1650 1660 1670 1680 ENEDLINSEG DSDVDSELED RVDGVKSWLS KNKGPSKAPS DDGSLKSSSP TSHWKPLAPD 1690 1700 1710 PSDDEHDPVD SISRPRFSHS YLSDSDTEAK LTETSA

References

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[1]	"Isolation of a novel PDZ-containing myosin from hematopoietic supportive bone marrow stromal cell lines." Furusawa T., Ikawa S., Yanai N., Obinata M. Biochem. Biophys. Res. Commun. 270:67-75(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Spleen.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-873 (ISOFORM 2). Strain: C57BL/6J. Tissue: Bone and Brain.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1032-2050 (ISOFORM 1). Strain: FVB/N. Tissue: Colon.
[5]	"A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival." Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z. Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH JAK3.
[6]	"Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)." Mori K., Furusawa T., Okubo T., Inoue T., Ikawa S., Yanai N., Mori K.J., Obinata M. J. Biochem. 133:405-413(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), DIFFERENTIAL EXPRESSION. Tissue: Spleen.
[7]	"A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling." Cross M., Csar X.F., Wilson N.J., Manes G., Addona T.A., Marks D.C., Whitty G.A., Ashman K., Hamilton J.A. Biochem. J. 380:243-253(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, MASS SPECTROMETRY.
[8]	"Subcellular localization and dynamics of MysPDZ (Myo18A) in live mammalian cells." Mori K., Matsuda K., Furusawa T., Kawata M., Inoue T., Obinata M. Biochem. Biophys. Res. Commun. 326:491-498(2005) [PubMed] [Europe PMC] [Abstract] Cited for: HOMODIMER, SUBCELLULAR LOCATION, INTERACTION WITH ACTIN.
[9]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1966 AND SER-1970, MASS SPECTROMETRY. Tissue: Liver.
[10]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 (ISOFORM 6), MASS SPECTROMETRY. Tissue: Brain cortex.
[11]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-74; SER-83; SER-102; SER-164; SER-1966; SER-2032; SER-2037 AND SER-2039, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-1966; SER-1970; SER-2016; SER-2037 AND SER-2039, MASS SPECTROMETRY. Tissue: Melanoma.
[13]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1966 AND SER-1970, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026497 mRNA. Translation: BAA93660.1. AK137574 mRNA. Translation: BAE23413.1. AK147584 mRNA. Translation: BAE28009.1. AK171342 mRNA. Translation: BAE42402.1. AL591065 Genomic DNA. Translation: CAI24424.1. AL591065 Genomic DNA. Translation: CAI24425.1. AL591065 Genomic DNA. Translation: CAI24426.1. AL591065 Genomic DNA. Translation: CAI24427.1. BC046638 mRNA. Translation: AAH46638.1.
IPI	IPI00407425. IPI00619995. IPI00622556. IPI00648918. IPI00649326. IPI00828545. IPI00828766.
RefSeq	NP_035716.1. NM_011586.2.
UniGene	Mm.341248. Mm.476162.
3D structure databases
ProteinModelPortal	Q9JMH9.
SMR	Q9JMH9. Positions 342-1243.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JMH9. 3 interactions.
PTM databases
PhosphoSite	Q9JMH9.
Proteomic databases
PaxDb	Q9JMH9.
PRIDE	Q9JMH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092884; ENSMUSP00000090560; ENSMUSG00000000631. ENSMUST00000092887; ENSMUSP00000090563; ENSMUSG00000000631. ENSMUST00000102488; ENSMUSP00000099546; ENSMUSG00000000631. ENSMUST00000108375; ENSMUSP00000104012; ENSMUSG00000000631. ENSMUST00000108376; ENSMUSP00000104013; ENSMUSG00000000631. ENSMUST00000130305; ENSMUSP00000119574; ENSMUSG00000000631. ENSMUST00000130627; ENSMUSP00000119839; ENSMUSG00000000631. ENSMUST00000164334; ENSMUSP00000131771; ENSMUSG00000000631. ENSMUST00000172303; ENSMUSP00000129098; ENSMUSG00000000631.
GeneID	360013.
KEGG	mmu:360013.
UCSC	uc007khg.1. mouse. uc007khh.1. mouse. uc007khi.1. mouse.
Organism-specific databases
CTD	399687.
MGI	MGI:2667185. Myo18a.
Phylogenomic databases
eggNOG	COG5022.
GeneTree	ENSGT00650000093350.
HOVERGEN	HBG052543.
KO	K10362.
Gene expression databases
ArrayExpress	Q9JMH9.
Bgee	Q9JMH9.
CleanEx	MM_MYO18A.
Genevestigator	Q9JMH9.
GermOnline	ENSMUSG00000000631. Mus musculus.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR002928. Myosin_tail. IPR001478. PDZ. [Graphical view]
Pfam	PF00063. Myosin_head. 2 hits. PF01576. Myosin_tail_1. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50096. IQ. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYO18A. mouse.
NextBio	400702.
SOURCE	Search...

Entry information

Entry name

MY18A_MOUSE

Accession

Primary (citable) accession number: Q9JMH9
Secondary accession number(s): Q3TBB2 , Q3UH48, Q3UV60, Q5SYN8, Q5SYN9, Q5SYP0, Q5SYP1, Q811D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program