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Q9JMH7

- NEUR3_MOUSE

UniProt

Q9JMH7 - NEUR3_MOUSE

Protein

Sialidase-3

Gene

Neu3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.1 Publication

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei25 – 251SubstrateBy similarity
    Binding sitei45 – 451SubstrateBy similarity
    Active sitei50 – 501Proton acceptorBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei181 – 1811SubstrateBy similarity
    Binding sitei223 – 2231SubstrateBy similarity
    Binding sitei243 – 2431SubstrateSequence Analysis
    Binding sitei339 – 3391SubstrateBy similarity
    Active sitei369 – 3691NucleophileBy similarity
    Active sitei386 – 3861Sequence Analysis

    GO - Molecular functioni

    1. alpha-sialidase activity Source: MGI
    2. exo-alpha-(2->3)-sialidase activity Source: UniProtKB
    3. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    4. exo-alpha-(2->8)-sialidase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: MGI
    2. ganglioside catabolic process Source: UniProtKB
    3. oligosaccharide catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_199008. Glycosphingolipid metabolism.
    REACT_202500. Sialic acid metabolism.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase-3 (EC:3.2.1.18)
    Alternative name(s):
    Ganglioside sialidase
    Membrane sialidase
    N-acetyl-alpha-neuraminidase 3
    Gene namesi
    Name:Neu3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1355305. Neu3.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Sialidase-3PRO_0000208904Add
    BLAST

    Proteomic databases

    PRIDEiQ9JMH7.

    PTM databases

    PhosphoSiteiQ9JMH7.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain and cerebral cortex.1 Publication

    Gene expression databases

    BgeeiQ9JMH7.
    CleanExiMM_NEU3.
    GenevestigatoriQ9JMH7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JMH7.
    SMRiQ9JMH7. Positions 10-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati129 – 14012BNR 1Add
    BLAST
    Repeati203 – 21412BNR 2Add
    BLAST
    Repeati254 – 26512BNR 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi24 – 274FRIP motif

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 3 BNR repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG84455.
    GeneTreeiENSGT00390000011171.
    HOGENOMiHOG000233778.
    HOVERGENiHBG052608.
    InParanoidiQ9JMH7.
    KOiK12357.
    OMAiVYLFFIC.
    OrthoDBiEOG7MSMNP.
    PhylomeDBiQ9JMH7.
    TreeFamiTF331063.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR026944. Sialidase-3.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF7. PTHR10628:SF7. 1 hit.
    SUPFAMiSSF50939. SSF50939. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9JMH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEVPPYSLS STLFQQEEQS GVTYRIPALL YLPPTHTFLA FAEKRTSVRD    50
    EDAACLVLRR GLMKGRSVQW GPQRLLMEAT LPGHRTMNPC PVWEKNTGRV 100
    YLFFICVRGH VTERCQIVWG KNAARLCFLC SEDAGCSWGE VKDLTEEVIG 150
    SEVKRWATFA VGPGHGIQLH SGRLIIPAYA YYVSRWFLCF ACSVKPHSLM 200
    IYSDDFGVTW HHGKFIEPQV TGECQVAEVA GTAGNPVLYC SARTPSRFRA 250
    EAFSTDSGGC FQKPTLNPQL HEPRTGCQGS VVSFRPLKMP NTYQDSIGKG 300
    APATQKCPLL DSPLEVEKGA ETPSATWLLY SHPTSKRKRI NLGIYYNRNP 350
    LEVNCWSRPW ILNRGPSGYS DLAVVEEQDL VACLFECGEK NEYERIDFCL 400
    FSDHEVLSCE DCTSPSSD 418
    Length:418
    Mass (Da):46,846
    Last modified:October 1, 2000 - v1
    Checksum:i64853FC963FE7686
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026842 mRNA. Translation: BAA92868.1.
    CCDSiCCDS21489.1.
    RefSeqiNP_057929.1. NM_016720.2.
    UniGeneiMm.103703.

    Genome annotation databases

    EnsembliENSMUST00000036331; ENSMUSP00000045222; ENSMUSG00000035239.
    GeneIDi50877.
    KEGGimmu:50877.
    UCSCiuc009imc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026842 mRNA. Translation: BAA92868.1 .
    CCDSi CCDS21489.1.
    RefSeqi NP_057929.1. NM_016720.2.
    UniGenei Mm.103703.

    3D structure databases

    ProteinModelPortali Q9JMH7.
    SMRi Q9JMH7. Positions 10-410.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    PTM databases

    PhosphoSitei Q9JMH7.

    Proteomic databases

    PRIDEi Q9JMH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036331 ; ENSMUSP00000045222 ; ENSMUSG00000035239 .
    GeneIDi 50877.
    KEGGi mmu:50877.
    UCSCi uc009imc.1. mouse.

    Organism-specific databases

    CTDi 10825.
    MGIi MGI:1355305. Neu3.

    Phylogenomic databases

    eggNOGi NOG84455.
    GeneTreei ENSGT00390000011171.
    HOGENOMi HOG000233778.
    HOVERGENi HBG052608.
    InParanoidi Q9JMH7.
    KOi K12357.
    OMAi VYLFFIC.
    OrthoDBi EOG7MSMNP.
    PhylomeDBi Q9JMH7.
    TreeFami TF331063.

    Enzyme and pathway databases

    Reactomei REACT_199008. Glycosphingolipid metabolism.
    REACT_202500. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 307853.
    PROi Q9JMH7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JMH7.
    CleanExi MM_NEU3.
    Genevestigatori Q9JMH7.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR026944. Sialidase-3.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF7. PTHR10628:SF7. 1 hit.
    SUPFAMi SSF50939. SSF50939. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation."
      Hasegawa T., Yamaguchi K., Wada T., Takeda A., Itoyama Y., Miyagi T.
      J. Biol. Chem. 275:8007-8015(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiNEUR3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JMH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3