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Q9JMH7

- NEUR3_MOUSE

UniProt

Q9JMH7 - NEUR3_MOUSE

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Protein

Sialidase-3

Gene

Neu3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.1 Publication

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251SubstrateBy similarity
Binding sitei45 – 451SubstrateBy similarity
Active sitei50 – 501Proton acceptorBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity
Binding sitei223 – 2231SubstrateBy similarity
Binding sitei243 – 2431SubstrateSequence Analysis
Binding sitei339 – 3391SubstrateBy similarity
Active sitei369 – 3691NucleophileBy similarity
Active sitei386 – 3861Sequence Analysis

GO - Molecular functioni

  1. alpha-sialidase activity Source: MGI
  2. exo-alpha-(2->3)-sialidase activity Source: UniProtKB
  3. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  4. exo-alpha-(2->8)-sialidase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: MGI
  2. ganglioside catabolic process Source: UniProtKB
  3. oligosaccharide catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.18)
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene namesi
Name:Neu3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1355305. Neu3.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Sialidase-3PRO_0000208904Add
BLAST

Proteomic databases

MaxQBiQ9JMH7.
PRIDEiQ9JMH7.

PTM databases

PhosphoSiteiQ9JMH7.

Expressioni

Tissue specificityi

Expressed in heart, brain and cerebral cortex.1 Publication

Gene expression databases

BgeeiQ9JMH7.
CleanExiMM_NEU3.
ExpressionAtlasiQ9JMH7. baseline and differential.
GenevestigatoriQ9JMH7.

Structurei

3D structure databases

ProteinModelPortaliQ9JMH7.
SMRiQ9JMH7. Positions 10-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 14012BNR 1Add
BLAST
Repeati203 – 21412BNR 2Add
BLAST
Repeati254 – 26512BNR 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 274FRIP motif

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated
Contains 3 BNR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG84455.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ9JMH7.
KOiK12357.
OMAiVYLFFIC.
OrthoDBiEOG7MSMNP.
PhylomeDBiQ9JMH7.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMiSSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9JMH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEVPPYSLS STLFQQEEQS GVTYRIPALL YLPPTHTFLA FAEKRTSVRD
60 70 80 90 100
EDAACLVLRR GLMKGRSVQW GPQRLLMEAT LPGHRTMNPC PVWEKNTGRV
110 120 130 140 150
YLFFICVRGH VTERCQIVWG KNAARLCFLC SEDAGCSWGE VKDLTEEVIG
160 170 180 190 200
SEVKRWATFA VGPGHGIQLH SGRLIIPAYA YYVSRWFLCF ACSVKPHSLM
210 220 230 240 250
IYSDDFGVTW HHGKFIEPQV TGECQVAEVA GTAGNPVLYC SARTPSRFRA
260 270 280 290 300
EAFSTDSGGC FQKPTLNPQL HEPRTGCQGS VVSFRPLKMP NTYQDSIGKG
310 320 330 340 350
APATQKCPLL DSPLEVEKGA ETPSATWLLY SHPTSKRKRI NLGIYYNRNP
360 370 380 390 400
LEVNCWSRPW ILNRGPSGYS DLAVVEEQDL VACLFECGEK NEYERIDFCL
410
FSDHEVLSCE DCTSPSSD
Length:418
Mass (Da):46,846
Last modified:October 1, 2000 - v1
Checksum:i64853FC963FE7686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026842 mRNA. Translation: BAA92868.1.
CCDSiCCDS21489.1.
RefSeqiNP_057929.1. NM_016720.2.
UniGeneiMm.103703.

Genome annotation databases

EnsembliENSMUST00000036331; ENSMUSP00000045222; ENSMUSG00000035239.
GeneIDi50877.
KEGGimmu:50877.
UCSCiuc009imc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026842 mRNA. Translation: BAA92868.1 .
CCDSi CCDS21489.1.
RefSeqi NP_057929.1. NM_016720.2.
UniGenei Mm.103703.

3D structure databases

ProteinModelPortali Q9JMH7.
SMRi Q9JMH7. Positions 10-410.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

PTM databases

PhosphoSitei Q9JMH7.

Proteomic databases

MaxQBi Q9JMH7.
PRIDEi Q9JMH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036331 ; ENSMUSP00000045222 ; ENSMUSG00000035239 .
GeneIDi 50877.
KEGGi mmu:50877.
UCSCi uc009imc.1. mouse.

Organism-specific databases

CTDi 10825.
MGIi MGI:1355305. Neu3.

Phylogenomic databases

eggNOGi NOG84455.
GeneTreei ENSGT00390000011171.
HOGENOMi HOG000233778.
HOVERGENi HBG052608.
InParanoidi Q9JMH7.
KOi K12357.
OMAi VYLFFIC.
OrthoDBi EOG7MSMNP.
PhylomeDBi Q9JMH7.
TreeFami TF331063.

Enzyme and pathway databases

Reactomei REACT_199008. Glycosphingolipid metabolism.
REACT_202500. Sialic acid metabolism.

Miscellaneous databases

NextBioi 307853.
PROi Q9JMH7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JMH7.
CleanExi MM_NEU3.
ExpressionAtlasi Q9JMH7. baseline and differential.
Genevestigatori Q9JMH7.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMi SSF50939. SSF50939. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation."
    Hasegawa T., Yamaguchi K., Wada T., Takeda A., Itoyama Y., Miyagi T.
    J. Biol. Chem. 275:8007-8015(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiNEUR3_MOUSE
AccessioniPrimary (citable) accession number: Q9JMH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3