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Protein

Sialidase-3

Gene

Neu3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.1 Publication

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstrateBy similarity1
Binding sitei45SubstrateBy similarity1
Active sitei50Proton acceptorBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei243SubstrateSequence analysis1
Binding sitei339SubstrateBy similarity1
Active sitei369NucleophileBy similarity1
Active sitei386Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-4085001. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Chemistry databases

SwissLipidsiSLP:000001371.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.18)
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene namesi
Name:Neu3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1355305. Neu3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089041 – 418Sialidase-3Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JMH7.
PaxDbiQ9JMH7.
PRIDEiQ9JMH7.

PTM databases

iPTMnetiQ9JMH7.
PhosphoSitePlusiQ9JMH7.

Expressioni

Tissue specificityi

Expressed in heart, brain and cerebral cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000035239.
CleanExiMM_NEU3.
ExpressionAtlasiQ9JMH7. baseline and differential.
GenevisibleiQ9JMH7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045222.

Structurei

3D structure databases

ProteinModelPortaliQ9JMH7.
SMRiQ9JMH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati129 – 140BNR 1Add BLAST12
Repeati203 – 214BNR 2Add BLAST12
Repeati254 – 265BNR 3Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 27FRIP motif4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated
Contains 3 BNR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFVF. Eukaryota.
ENOG410Y74Z. LUCA.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ9JMH7.
KOiK12357.
OMAiVYLFFIC.
OrthoDBiEOG091G08BI.
PhylomeDBiQ9JMH7.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF23. PTHR10628:SF23. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9JMH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVPPYSLS STLFQQEEQS GVTYRIPALL YLPPTHTFLA FAEKRTSVRD
60 70 80 90 100
EDAACLVLRR GLMKGRSVQW GPQRLLMEAT LPGHRTMNPC PVWEKNTGRV
110 120 130 140 150
YLFFICVRGH VTERCQIVWG KNAARLCFLC SEDAGCSWGE VKDLTEEVIG
160 170 180 190 200
SEVKRWATFA VGPGHGIQLH SGRLIIPAYA YYVSRWFLCF ACSVKPHSLM
210 220 230 240 250
IYSDDFGVTW HHGKFIEPQV TGECQVAEVA GTAGNPVLYC SARTPSRFRA
260 270 280 290 300
EAFSTDSGGC FQKPTLNPQL HEPRTGCQGS VVSFRPLKMP NTYQDSIGKG
310 320 330 340 350
APATQKCPLL DSPLEVEKGA ETPSATWLLY SHPTSKRKRI NLGIYYNRNP
360 370 380 390 400
LEVNCWSRPW ILNRGPSGYS DLAVVEEQDL VACLFECGEK NEYERIDFCL
410
FSDHEVLSCE DCTSPSSD
Length:418
Mass (Da):46,846
Last modified:October 1, 2000 - v1
Checksum:i64853FC963FE7686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026842 mRNA. Translation: BAA92868.1.
CCDSiCCDS21489.1.
RefSeqiNP_057929.1. NM_016720.2.
UniGeneiMm.103703.

Genome annotation databases

EnsembliENSMUST00000036331; ENSMUSP00000045222; ENSMUSG00000035239.
GeneIDi50877.
KEGGimmu:50877.
UCSCiuc009imc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026842 mRNA. Translation: BAA92868.1.
CCDSiCCDS21489.1.
RefSeqiNP_057929.1. NM_016720.2.
UniGeneiMm.103703.

3D structure databases

ProteinModelPortaliQ9JMH7.
SMRiQ9JMH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045222.

Chemistry databases

SwissLipidsiSLP:000001371.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

PTM databases

iPTMnetiQ9JMH7.
PhosphoSitePlusiQ9JMH7.

Proteomic databases

MaxQBiQ9JMH7.
PaxDbiQ9JMH7.
PRIDEiQ9JMH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036331; ENSMUSP00000045222; ENSMUSG00000035239.
GeneIDi50877.
KEGGimmu:50877.
UCSCiuc009imc.1. mouse.

Organism-specific databases

CTDi10825.
MGIiMGI:1355305. Neu3.

Phylogenomic databases

eggNOGiENOG410IFVF. Eukaryota.
ENOG410Y74Z. LUCA.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ9JMH7.
KOiK12357.
OMAiVYLFFIC.
OrthoDBiEOG091G08BI.
PhylomeDBiQ9JMH7.
TreeFamiTF331063.

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-4085001. Sialic acid metabolism.

Miscellaneous databases

PROiQ9JMH7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035239.
CleanExiMM_NEU3.
ExpressionAtlasiQ9JMH7. baseline and differential.
GenevisibleiQ9JMH7. MM.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF23. PTHR10628:SF23. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNEUR3_MOUSE
AccessioniPrimary (citable) accession number: Q9JMH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.