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Q9JMH7 (NEUR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialidase-3

EC=3.2.1.18
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene names
Name:Neu3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Ref.1

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Ref.1

Subcellular location

Cell membrane; Peripheral membrane protein By similarity.

Tissue specificity

Expressed in heart, brain and cerebral cortex. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Contains 3 BNR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Sialidase-3
PRO_0000208904

Regions

Repeat129 – 14012BNR 1
Repeat203 – 21412BNR 2
Repeat254 – 26512BNR 3
Motif24 – 274FRIP motif

Sites

Active site501Proton acceptor By similarity
Active site3691Nucleophile By similarity
Active site3861 Potential
Binding site251Substrate By similarity
Binding site451Substrate By similarity
Binding site1791Substrate By similarity
Binding site1811Substrate By similarity
Binding site2231Substrate By similarity
Binding site2431Substrate Potential
Binding site3391Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JMH7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 64853FC963FE7686

FASTA41846,846
        10         20         30         40         50         60 
MEEVPPYSLS STLFQQEEQS GVTYRIPALL YLPPTHTFLA FAEKRTSVRD EDAACLVLRR 

        70         80         90        100        110        120 
GLMKGRSVQW GPQRLLMEAT LPGHRTMNPC PVWEKNTGRV YLFFICVRGH VTERCQIVWG 

       130        140        150        160        170        180 
KNAARLCFLC SEDAGCSWGE VKDLTEEVIG SEVKRWATFA VGPGHGIQLH SGRLIIPAYA 

       190        200        210        220        230        240 
YYVSRWFLCF ACSVKPHSLM IYSDDFGVTW HHGKFIEPQV TGECQVAEVA GTAGNPVLYC 

       250        260        270        280        290        300 
SARTPSRFRA EAFSTDSGGC FQKPTLNPQL HEPRTGCQGS VVSFRPLKMP NTYQDSIGKG 

       310        320        330        340        350        360 
APATQKCPLL DSPLEVEKGA ETPSATWLLY SHPTSKRKRI NLGIYYNRNP LEVNCWSRPW 

       370        380        390        400        410 
ILNRGPSGYS DLAVVEEQDL VACLFECGEK NEYERIDFCL FSDHEVLSCE DCTSPSSD 

« Hide

References

[1]"Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation."
Hasegawa T., Yamaguchi K., Wada T., Takeda A., Itoyama Y., Miyagi T.
J. Biol. Chem. 275:8007-8015(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026842 mRNA. Translation: BAA92868.1.
RefSeqNP_057929.1. NM_016720.2.
UniGeneMm.103703.

3D structure databases

ProteinModelPortalQ9JMH7.
SMRQ9JMH7. Positions 10-410.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH33. Glycoside Hydrolase Family 33.

PTM databases

PhosphoSiteQ9JMH7.

Proteomic databases

PRIDEQ9JMH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036331; ENSMUSP00000045222; ENSMUSG00000035239.
GeneID50877.
KEGGmmu:50877.
UCSCuc009imc.1. mouse.

Organism-specific databases

CTD10825.
MGIMGI:1355305. Neu3.

Phylogenomic databases

eggNOGNOG84455.
GeneTreeENSGT00390000011171.
HOGENOMHOG000233778.
HOVERGENHBG052608.
InParanoidQ9JMH7.
KOK12357.
OMAVYLFFIC.
OrthoDBEOG7MSMNP.
PhylomeDBQ9JMH7.
TreeFamTF331063.

Gene expression databases

BgeeQ9JMH7.
CleanExMM_NEU3.
GenevestigatorQ9JMH7.

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMSSF50939. SSF50939. 2 hits.
ProtoNetSearch...

Other

NextBio307853.
PROQ9JMH7.
SOURCESearch...

Entry information

Entry nameNEUR3_MOUSE
AccessionPrimary (citable) accession number: Q9JMH7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries