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Protein

Sialidase-2

Gene

Neu2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Binding sitei41SubstrateBy similarity1
Active sitei46Proton acceptorBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei237SubstrateSequence analysis1
Active sitei303By similarity1
Binding sitei303SubstrateBy similarity1
Active sitei333NucleophileBy similarity1
Active sitei354Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism
R-MMU-4085001 Sialic acid metabolism

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-2 (EC:3.2.1.18)
Alternative name(s):
Cytosolic sialidase
Mouse skeletal muscle sialidase
Short name:
MSS
Murine thymic sialidase
Short name:
MTS
N-acetyl-alpha-neuraminidase 2
Gene namesi
Name:Neu2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1344417 Neu2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089001 – 379Sialidase-2Add BLAST379

Proteomic databases

MaxQBiQ9JMH3
PaxDbiQ9JMH3
PRIDEiQ9JMH3

PTM databases

iPTMnetiQ9JMH3
PhosphoSitePlusiQ9JMH3

Expressioni

Tissue specificityi

Highly expressed in heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000079434
CleanExiMM_NEU2
ExpressionAtlasiQ9JMH3 baseline and differential
GenevisibleiQ9JMH3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131409

Structurei

3D structure databases

ProteinModelPortaliQ9JMH3
SMRiQ9JMH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 138BNR 1Add BLAST12
Repeati197 – 208BNR 2Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23FRIP motif4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFVF Eukaryota
ENOG410Y74Z LUCA
GeneTreeiENSGT00390000011171
HOGENOMiHOG000233778
HOVERGENiHBG052608
InParanoidiQ9JMH3
KOiK12357
PhylomeDBiQ9JMH3
TreeFamiTF331063

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026945 Sialidase-2
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PTHR10628:SF6 PTHR10628:SF6, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JMH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCPVLQKE TLFRTGVHAY RIPALLYLKK QKTLLAFAEK RASKTDEHAE
60 70 80 90 100
LIVLRRGSYN EATNRVKWQP EEVVTQAQLE GHRSMNPCPL YDKQTKTLFL
110 120 130 140 150
FFIAVPGRVS EHHQLHTKVN VTRLCCVSST DHGRTWSPIQ DLTETTIGST
160 170 180 190 200
HQEWATFAVG PGHCLQLRNP AGSLLVPAYA YRKLHPAQKP TPFAFCFISL
210 220 230 240 250
DHGHTWKLGN FVAENSLECQ VAEVGTGAQR MVYLNARSFL GARVQAQSPN
260 270 280 290 300
DGLDFQDNRV VSKLVEPPHG CHGSVVAFHN PISKPHALDT WLLYTHPTDS
310 320 330 340 350
RNRTNLGVYL NQMPLDPTAW SEPTLLAMGI CAYSDLQNMG QGPDGSPQFG
360 370
CLYESGNYEE IIFLIFTLKQ AFPTVFDAQ
Length:379
Mass (Da):42,403
Last modified:October 1, 2000 - v1
Checksum:i02124A46398F6793
GO

Sequence cautioni

The sequence BAB39152 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40K → R in AF139059 (PubMed:10329453).Curated1
Sequence conflicti91 – 97YDKQTKT → MTSKKD in AF139059 (PubMed:10329453).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139059 mRNA No translation available.
AB028023 mRNA Translation: BAA92867.1
AB048604 mRNA Translation: BAB39152.1 Different initiation.
CCDSiCCDS15135.1
RefSeqiNP_001153635.1, NM_001160163.1
NP_001153636.1, NM_001160164.1
NP_001153637.1, NM_001160165.1
NP_056565.1, NM_015750.3
XP_006529587.1, XM_006529524.3
UniGeneiMm.143717

Genome annotation databases

EnsembliENSMUST00000070898; ENSMUSP00000065439; ENSMUSG00000079434
ENSMUST00000165109; ENSMUSP00000126509; ENSMUSG00000079434
ENSMUST00000166259; ENSMUSP00000132513; ENSMUSG00000079434
GeneIDi23956
KEGGimmu:23956
UCSCiuc007bxa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNEUR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JMH3
Secondary accession number(s): Q99NA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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