Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatoma-derived growth factor-related protein 3

Gene

Hdgfrp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances DNA synthesis and may play a role in cell proliferation.By similarity

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: MGI
  • microtubule polymerization Source: UniProtKB
  • negative regulation of microtubule depolymerization Source: UniProtKB
  • neuron projection development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name:
HRP-3
Gene namesi
Name:Hdgfrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352760. Hdgfrp3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Hepatoma-derived growth factor-related protein 3PRO_0000191704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101PhosphothreonineCombined sources
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei161 – 1611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JMG7.
MaxQBiQ9JMG7.
PaxDbiQ9JMG7.
PeptideAtlasiQ9JMG7.
PRIDEiQ9JMG7.

PTM databases

iPTMnetiQ9JMG7.
PhosphoSiteiQ9JMG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025104.
CleanExiMM_HDGFRP3.
GenevisibleiQ9JMG7. MM.

Interactioni

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi205940. 2 interactions.
IntActiQ9JMG7. 1 interaction.
MINTiMINT-4130418.
STRINGi10090.ENSMUSP00000102926.

Structurei

Secondary structure

1
202
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 185Combined sources
Beta strandi24 – 296Combined sources
Beta strandi44 – 485Combined sources
Turni49 – 513Combined sources
Beta strandi54 – 574Combined sources
Helixi59 – 613Combined sources
Beta strandi62 – 643Combined sources
Helixi65 – 728Combined sources
Beta strandi78 – 803Combined sources
Helixi81 – 899Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N27NMR-A8-90[»]
ProteinModelPortaliQ9JMG7.
SMRiQ9JMG7. Positions 8-91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JMG7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6858PWWPPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 14713Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG410Y5WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ9JMG7.
OMAiFTGYQAM.
OrthoDBiEOG091G045X.
PhylomeDBiQ9JMG7.
TreeFamiTF105385.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JMG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
TIQQQSSSET EGEGGNTADA SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT
160 170 180 190 200
SKKSSKQSRK SPGDEDDKDC KEEENKSSSE GGDAGNDTRN TTADLQKAGE

GT
Length:202
Mass (Da):22,431
Last modified:June 21, 2005 - v2
Checksum:iFCDB31BD2BEAB8D6
GO
Isoform 2 (identifier: Q9JMG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-202: T → VRMC

Note: No experimental confirmation available.
Show »
Length:205
Mass (Da):22,819
Checksum:iE2AEAE3FBB31BD2B
GO

Sequence cautioni

The sequence BAC32413 differs from that shown. Reason: Frameshift at position 162. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1992AG → TS in BAA90478 (PubMed:10581169).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei202 – 2021T → VRMC in isoform 2. 1 PublicationVSP_014188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029493 mRNA. Translation: BAA90478.1.
AK019487 mRNA. Translation: BAB31754.1.
AK044858 mRNA. Translation: BAC32123.1.
AK045542 mRNA. Translation: BAC32413.1. Frameshift.
AK051401 mRNA. Translation: BAC34628.1.
AK162418 mRNA. Translation: BAE36904.1.
BC055734 mRNA. Translation: AAH55734.1.
CCDSiCCDS40011.1. [Q9JMG7-1]
RefSeqiNP_038914.2. NM_013886.4. [Q9JMG7-1]
UniGeneiMm.392934.

Genome annotation databases

EnsembliENSMUST00000026094; ENSMUSP00000026094; ENSMUSG00000025104. [Q9JMG7-2]
ENSMUST00000107305; ENSMUSP00000102926; ENSMUSG00000025104. [Q9JMG7-1]
GeneIDi29877.
KEGGimmu:29877.
UCSCiuc009icr.1. mouse. [Q9JMG7-1]
uc009ics.1. mouse. [Q9JMG7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029493 mRNA. Translation: BAA90478.1.
AK019487 mRNA. Translation: BAB31754.1.
AK044858 mRNA. Translation: BAC32123.1.
AK045542 mRNA. Translation: BAC32413.1. Frameshift.
AK051401 mRNA. Translation: BAC34628.1.
AK162418 mRNA. Translation: BAE36904.1.
BC055734 mRNA. Translation: AAH55734.1.
CCDSiCCDS40011.1. [Q9JMG7-1]
RefSeqiNP_038914.2. NM_013886.4. [Q9JMG7-1]
UniGeneiMm.392934.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N27NMR-A8-90[»]
ProteinModelPortaliQ9JMG7.
SMRiQ9JMG7. Positions 8-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205940. 2 interactions.
IntActiQ9JMG7. 1 interaction.
MINTiMINT-4130418.
STRINGi10090.ENSMUSP00000102926.

PTM databases

iPTMnetiQ9JMG7.
PhosphoSiteiQ9JMG7.

Proteomic databases

EPDiQ9JMG7.
MaxQBiQ9JMG7.
PaxDbiQ9JMG7.
PeptideAtlasiQ9JMG7.
PRIDEiQ9JMG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026094; ENSMUSP00000026094; ENSMUSG00000025104. [Q9JMG7-2]
ENSMUST00000107305; ENSMUSP00000102926; ENSMUSG00000025104. [Q9JMG7-1]
GeneIDi29877.
KEGGimmu:29877.
UCSCiuc009icr.1. mouse. [Q9JMG7-1]
uc009ics.1. mouse. [Q9JMG7-2]

Organism-specific databases

CTDi50810.
MGIiMGI:1352760. Hdgfrp3.

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG410Y5WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ9JMG7.
OMAiFTGYQAM.
OrthoDBiEOG091G045X.
PhylomeDBiQ9JMG7.
TreeFamiTF105385.

Miscellaneous databases

EvolutionaryTraceiQ9JMG7.
PROiQ9JMG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025104.
CleanExiMM_HDGFRP3.
GenevisibleiQ9JMG7. MM.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDGR3_MOUSE
AccessioniPrimary (citable) accession number: Q9JMG7
Secondary accession number(s): Q3TRX2
, Q8BQ69, Q8BR62, Q9D2M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.