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Q9JMG6 (TFPT_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
TCF3 fusion partner homolog
Alternative name(s):
Protein amida
Gene names
Name:Tfpt
Synonyms:Amida
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to promote apoptosis in a p53/TP53-independent manner. Ref.2

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair By similarity. Ref.2

Subunit structure

Interacts with NOL3. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 By similarity. Ref.2

Subcellular location

Nucleus Ref.2.

Tissue specificity

Ubiquitously expressed. Abundant in the brain. Ref.2

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PawrQ626278EBI-1767101,EBI-1187240

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259TCF3 fusion partner homolog
PRO_0000254583

Amino acid modifications

Modified residue1801Phosphoserine By similarity
Modified residue1881Phosphoserine By similarity
Modified residue2031Phosphothreonine By similarity
Modified residue2551Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JMG6 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 674408B3F3FB6863

FASTA25928,908
        10         20         30         40         50         60 
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGDSGLRER 

        70         80         90        100        110        120 
DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL 

       130        140        150        160        170        180 
MRVLDSYGDD YRDSQFTIVL EDDGSQGTDV PTPGNVENEP PEKEGLSPPQ RTTATLDPSS 

       190        200        210        220        230        240 
PAPGEGPSGR KRRRAPRAAS SLTPELAPVQ VGAEGWGQGV IKVEEDFGFE ADEALDSSWV 

       250 
SRGPDKLLPY PTLASPPFD

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells."
Irie Y., Yamagata K., Gan Y., Miyamoto K., Do E., Kuo C.H., Taira E., Miki N.
J. Biol. Chem. 275:2647-2653(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-259, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, POSSIBLE FUNCTION IN APOPTOSIS, INTERACTION WITH NOL3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC103574 Genomic DNA. No translation available.
AB029495 mRNA. Translation: BAA90702.1.
RefSeqNP_620225.1. NM_138870.1.
UniGeneRn.12922.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9JMG6. 1 interaction.
STRING10116.ENSRNOP00000018913.

PTM databases

PhosphoSiteQ9JMG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018913; ENSRNOP00000018913; ENSRNOG00000013980.
GeneID85423.
KEGGrno:85423.
UCSCRGD:620839. rat.

Organism-specific databases

CTD29844.
RGD620839. Tfpt.

Phylogenomic databases

eggNOGNOG41576.
GeneTreeENSGT00390000016605.
HOGENOMHOG000139148.
HOVERGENHBG056588.
InParanoidQ9JMG6.
KOK11670.

Gene expression databases

ArrayExpressQ9JMG6.
GenevestigatorQ9JMG6.
GermOnlineENSRNOG00000013980. Rattus norvegicus.

Family and domain databases

ProtoNetSearch...

Other

NextBio617514.

Entry information

Entry nameTFPT_RAT
AccessionPrimary (citable) accession number: Q9JMG6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 3, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info