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Protein

C1GALT1-specific chaperone 1

Gene

C1galt1c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • O-glycan processing, core 1 Source: GO_Central
  • platelet activation Source: MGI
  • platelet morphogenesis Source: MGI
  • protein O-linked glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
C1GALT1-specific chaperone 1
Alternative name(s):
Core 1 beta1,3-galactosyltransferase 2
Short name:
C1Gal-T2
Short name:
C1GalT2
Short name:
Core 1 beta3-Gal-T2
Short name:
mC1Gal-T2
Core 1 beta3-galactosyltransferase-specific molecular chaperone
Gene namesi
Name:C1galt1c1
Synonyms:Cosmc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913493. C1galt1c1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini27 – 316LumenalSequence analysisAdd BLAST290

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850751 – 316C1GALT1-specific chaperone 1Add BLAST316

Proteomic databases

EPDiQ9JMG2.
MaxQBiQ9JMG2.
PaxDbiQ9JMG2.
PeptideAtlasiQ9JMG2.
PRIDEiQ9JMG2.

PTM databases

iPTMnetiQ9JMG2.
PhosphoSitePlusiQ9JMG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048970.
CleanExiMM_C1GALT1C1.
GenevisibleiQ9JMG2. MM.

Interactioni

Subunit structurei

Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059224.

Structurei

3D structure databases

ProteinModelPortaliQ9JMG2.
SMRiQ9JMG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ9JMG2.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG091G0F36.
PhylomeDBiQ9JMG2.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JMG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSESSSFLK GVMLGSIFCA LITMLGHIRI GNRMHHHEHH HLQAPNKDDI
60 70 80 90 100
SKISEAERME LSKSFRVYCI VLVKPKDVSL WAAVKETWTK HCDKAEFFSS
110 120 130 140 150
ENVKVFESIN MDTNDMWLMM RKAYKYAYDQ YRDQYNWFFL ARPTTFAVIE
160 170 180 190 200
NLKYFLLKKD QSQPFYLGHT VKSGDLEYVS VDGGIVLSIE SMKRLNSLLS
210 220 230 240 250
VPEKCPEQGG MIWKISEDKQ LAVCLKYAGV FAENAEDADG KDVFNTKSVG
260 270 280 290 300
LFIKEAMTNQ PNQVVEGCCS DMAVTFNGLT PNQMHVMMYG VYRLRAFGHV
310
FNDALVFLPP NGSEND
Length:316
Mass (Da):36,067
Last modified:October 1, 2000 - v1
Checksum:i9B7BFCBD6E834B2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030184 mRNA. Translation: BAA92748.1.
AY159320 mRNA. Translation: AAN78130.1.
AB091728 mRNA. Translation: BAD13521.1.
AK008040 mRNA. Translation: BAB25426.1.
AL590633 Genomic DNA. Translation: CAM17626.1.
BC029909 mRNA. Translation: AAH29909.1.
CCDSiCCDS30095.1.
RefSeqiNP_067525.1. NM_021550.3.
UniGeneiMm.441410.

Genome annotation databases

EnsembliENSMUST00000058265; ENSMUSP00000059224; ENSMUSG00000048970.
GeneIDi59048.
KEGGimmu:59048.
UCSCiuc009tag.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

C1GALT2 (same seq as COSMC)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030184 mRNA. Translation: BAA92748.1.
AY159320 mRNA. Translation: AAN78130.1.
AB091728 mRNA. Translation: BAD13521.1.
AK008040 mRNA. Translation: BAB25426.1.
AL590633 Genomic DNA. Translation: CAM17626.1.
BC029909 mRNA. Translation: AAH29909.1.
CCDSiCCDS30095.1.
RefSeqiNP_067525.1. NM_021550.3.
UniGeneiMm.441410.

3D structure databases

ProteinModelPortaliQ9JMG2.
SMRiQ9JMG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059224.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

iPTMnetiQ9JMG2.
PhosphoSitePlusiQ9JMG2.

Proteomic databases

EPDiQ9JMG2.
MaxQBiQ9JMG2.
PaxDbiQ9JMG2.
PeptideAtlasiQ9JMG2.
PRIDEiQ9JMG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058265; ENSMUSP00000059224; ENSMUSG00000048970.
GeneIDi59048.
KEGGimmu:59048.
UCSCiuc009tag.2. mouse.

Organism-specific databases

CTDi29071.
MGIiMGI:1913493. C1galt1c1.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ9JMG2.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG091G0F36.
PhylomeDBiQ9JMG2.
TreeFamiTF317293.

Enzyme and pathway databases

ReactomeiR-MMU-913709. O-linked glycosylation of mucins.

Miscellaneous databases

PROiQ9JMG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048970.
CleanExiMM_C1GALT1C1.
GenevisibleiQ9JMG2. MM.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC1GLC_MOUSE
AccessioniPrimary (citable) accession number: Q9JMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally assigned to be a glycosyltransferase.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.